Significance. This proposal fits into Intel’s digital health vision where we can extend the PC penetration into the elders' households; therefore creating a new potential market for Intel-based PCs and communication products. In addition, the proposed home-care application is likely to generate high sensor data processing and communication workload, leading to demand for Intel-based PC and communication products upgrades. Home gateway PC runs
Significance. Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field? Does the project address the burden (including preliminary data when available), need, and impact of the occupational exposures and hazards that are the focus of the proposed research? Does the applicant fully justify and provide data to describe the burden of the problem(s) being addressed? Is the project likely to have an impact in meeting local, regional or national occupational safety and health needs through effective research, intervention, translation, outreach, education, or partnership activities? Are appropriate impacts identified? In addition, for applications proposing clinical trials: Are the scientific rationale and need for a clinical trial to test the proposed hypothesis or intervention well-supported by preliminary data, clinical and/or preclinical studies, or information in the literature or knowledge of biological mechanisms? For trials focusing on clinical or public health endpoints, is this clinical trial necessary for testing the safety, efficacy or effectiveness of an intervention that could lead to a change in clinical practice, community behaviors or health care policy? For trials focusing on mechanistic, behavioral, physiological, biochemical, or other biomedical endpoints, is this trial needed to advance scientific understanding? Investigator(s) Are the PD/PIs, collaborators, and other researchers well suited to the project? Have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD/PI, do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project? In addition, for applications proposing clinical trials: With regard to the proposed leadership for the project, do the PD/PI(s) and key personnel have the expertise, experience, and ability to organize, manage and implement the proposed clinical trial and meet milestones and timelines? Do they have appropriate expertise in study coordination, data management and statistics? For a multicenter trial, is the organizational stru...
Significance. The development of a vaccine to prevent AIDS is the best hope for controlling the epidemic that has led to infection of more than 30 million people with the HIV-1 virus worldwide. A vaccine approach that reduces viral load would certainly be beneficial, but one that elicits sterilizing immunity would be preferred. Conventional vaccine approaches based on delivery of HIV-1 envelope (Env) proteins or peptides derived from Env sequences have failed to generate broadly neutralizing antibodies (bNAbs) to the virus, which mutates rapidly to escape from the immune response. Recently, [*] have been discovered from subjects in the [*]. Several of these antibodies, including [*] determinants alone or in the context of the [*] protein. Importantly, these antibodies are even more potent (i.e., they neutralize HIV-1 at lower antibody concentrations) than other newly discovered [*]. Immunogens that elicit antibodies similar to the [*] could be ideal vaccine candidates.
Significance. The results of the study provide insight into the factors that reduce the effectiveness of the partnership between pedagogical universities and schools, helping policy makers and educational managers have appropriate measures to develop the professionalism of teachers in high schools and help pre-service students prepare for future careers.
Significance. It is expected to enhance research and innovation cooperation in different fields like Water, Energy, Healthcare, Agritech & Bioeconomy, Integrated Cyber-Physical Systems, Information and Communication Technologies, Nanotechnology, and clean technologies, etc. It will also strengthen the institutional linkages in research, exchange of researchers, students, startups and attract co-investment of resources for co-generation of knowledge.
Significance. GDM represents a common and serious health care problem in the U.S. and around the world. Increasing evidence from randomized controlled trials (RCT) indicate that lifestyle intervention programs based on promoting good nutrition and physical activity before and early in pregnancy may lower the incidence of GDM (Yin et al., 2014). Some lifestyle intervention studies have reported improvements in risk factors associated with GDM in Caucasian women (Xxxxxx-Xxxxx, 2015); however, the impact of such intervention in Hispanic women has not been investigated. We believe that screening and intervention programs will have a positive impact not only in limiting weight gain during pregnancy, but also in preventing GDM and its complication in overweight/obese Hispanic women.
Significance. A thorough understanding of a historic asset’s significance is the starting point for any sound management plan. Every HPA should include a statement that addresses the collective and individual significance of the assets covered by the agreement. The statement of significance should consider the assets together and identify any collective significance arising, for instance, from shared functions, construction techniques or designs. It should also give brief descriptions of the individual assets in the context of the whole. Focusing on the heritage values of the historic assets will help in the analysis of their significance: • evidential value: the extent to which the physical fabric tells how and when an asset was made, how it was used and how it has changed over time • historical value: a historic asset may illustrate a particular past way of life or be associated with a specific person or event and there may be physical evidence for these connections which it could be important to retain • aesthetic value: the design, construction and craftsmanship of an asset, which can also include the setting and views to and from a historic asset • communal value: an historic asset may have particular significance to people for its commemorative, symbolic or spiritual value, or for the part it has played in local cultural or public life. Cadw’s Conservation Principles for the sustainable management of the historic environment in Wales7 provides further information on heritage values. Works The parties to the HPA will have to agree the works that need to be undertaken during the lifetime of the agreement to achieve its objectives. A historic asset’s significance should be a central consideration when formulating any plans. The works should aim to realise the greatest benefit and cause the least harm, so the significance of the asset is sustained or enhanced. If the HPA includes planned works to a listed building that is not a private dwelling, consideration will also need to be given to access issues. The planned works will need to provide reasonable access and have the least detrimental impact on the significance of the listed building. Heritage Impact Assessment in Wales8 provides further information on access issues. An HPA cannot give consent for the demolition of a listed building, the demolition or destruction of a scheduled monument, or tipping on or the flooding of a scheduled monument.9 Every HPA must provide detailed specifications for the works that will ...
Significance. More than 80,000 people each week are served by food security assistance organizations that receive their food from ACFB. This is a tremendous amount of people in the Atlanta and NW Georgia region. ACFB has the ability to positively or negatively affect these individuals’ diet by the food they acquire and distribute, thus, monitoring the distribution patterns of ACFB, and understanding how partner agencies interpret and translate nutrition resources into their food acquisition process is needed for understanding the NW Georgian culture of health. The mission of ACFB is to fight hunger by engaging, educating, and empowering its community; therefore, implementing a nutrition program centered on choice is a simple way to evaluate nutrition outreach education from ACFB to the community. Additionally, the food insecure populations of Georgia deserve healthy and nutritious food assistance that is culturally appropriate along with options that they enjoy eating. Chapter 2: Comprehensive Review of Literature
Significance. “Explain the importance of the problem or critical barrier to progress in the field that the proposed research addresses… Explain how the proposed project will improve scientific knowledge, technical capability, and/or clinical practice” in the field of HIV/AIDS.1 In this section, you may wish to: Critically review the relevant literature, including its strengths and weaknesses Establish the scientific premise of your proposal Describe the importance of the research, including its relevance to High and/or Medium Priority Topics for HIV/AIDS Research.2 This section is typically about half to three-quarters of a page in length. Preliminary Studies “Discuss [your team’s] preliminary studies, data, and or experience pertinent to this application.”1 You may wish to highlight these data in particular: The preliminary data that supports your hypothesis The preliminary data that supports your ability to complete the work successfully This section is typically about half to three-quarters of a page in length and often includes tables or figures. Experimental Design and Methods “Describe the overall strategy, methodology, and analyses to be used to accomplish the specific aims of the project.”1 This section details the approach and typically answers the following questions: What will be done and how will you do it (Research Design, Analytic Strategy, Timeline, etc.)? What are the possible challenges, expected outcomes (e.g., including but not limited to research findings, potential publications, and external grant funding), and future directions? In addition to the above standard sections that would be included in an NIH grant, strong applications also should clearly emphasize: The potential for capacity building at the foreign site How the project would benefit the foreign site XX’s career This section is typically about 2 to 2.5 pages in length and often includes tables or figures. Literature Cited (not included in 4 page limit) INTERNATIONAL RESEARCH OBJECTIVES The SD CFAR seeks to fund international research that can be completed in a timely manner, contribute to the careers of international HIV/AIDS investigators, and build capacity for future HIV/AIDS research. Please respond to the following items so we can evaluate your proposed study in terms of our overall objectives. Delete all highlighted instructions before submitting your application. Previously Funded CFAR Grants Have you (the international Principal Investigator) previously received one or more grant...
Significance. This Agreement shall be interpreted and construed in a fair and impartial manner without regard to such factors as the party which prepared the instrument, the relative bargaining powers of the parties or the domicile of any party.
