Specific Aims. “State concisely the goals of the proposed research and summarize the expected outcome(s), including the impact that the results of the proposed research will exert” on the field of HIV/AIDS research.1 In the context of this application, you may wish to: Identify the relevant gap in knowledge and rationale for the research Highlight the objective of the proposal Describe the hypothesis to be tested and expected outcome State how the successful completion of this project will impact the field This section is typically about a half-page in length.
Specific Aims. Under this contract, Principal Investigator shall conduct research as outlined in the specific aims of the application submitted titled: “Insert Project Title” and on file in the AASM Foundation’s National Office. Principal Investigator will use its reasonable best efforts to conduct this research in accordance with generally accepted scientific and professional standards.
Specific Aims. 1. To determine whether an early bilingual culturally grounded lifestyle intervention program based on healthy eating and exercise will improve the percentage of women who are compliant with GWG (IOM guidelines) in overweight/obese Hispanic women. Hypothesis: Overweight and obese Hispanic women who participate in an early lifestyle intervention program will improve healthy eating habits and physical activity and result in a higher compliance with Institute of Medicine guidelines for GWG, when compared to patients receiving standard care. Intervention should also improve post-partum weight loss.
Specific Aims. Aim I. Targeted synthetic chemical modifications of current lead PKCδ inhibitors. Aim II. Testing new PKCδ inhibitors for PKCδ-inhibitory activity and for PKCδ isozyme-specificity.
Specific Aims. [†] [Redaction continues for three pages] † DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION EXHIBIT C To the Exclusive License and Sponsored Research Agreement Between Omeros Corporation and the University of Leicester MUTUAL CONFIDENTIALITY AGREEMENT † DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION
Specific Aims. Deep brain stimulation (DBS) is a therapy that is presently primarily applied to movement disorders, but has shown promise in a number of other neurological conditions. In order for DBS therapy to provide maximum benefit with minimal side effects, electrodes must be precisely positioned at specific structures in the brain. The present methodology for implantation of DBS electrodes is to employ stereotactic methods, which are seeded with pre-operative magnetic resonance (MR) or computed tomography (CT) images. Unfortunately, stereotaxy alone does not provide the accuracy necessary for DBS therapy and thus intra-operative physiologic tests are commonly employed to indirectly infer position prior to electrode insertion. These tests are invasive, time consuming and require the patient to be awake and off their movement disorder medications during surgery. We are pioneering a novel technique for implanting DBS electrodes with intra-operative MR guidance. The use of intra-operative MR imaging has several significant advantages, including the ability to directly visualize the deep brain target and confirm technical success prior to completion of surgery. It may obviate the need for invasive physiologic tests on awake patients and therefore open the therapy up to a wider range of patients and clinical conditions. It further has the potential to substantially simplify and shorten the operative procedure, minimize the risk of hemorrhagic complications, and result in more accurate and consistent DBS electrode positioning. Our approach, however, essentially precludes the acquisition of intra-operative physiologic evaluations of the patient. We must therefore be able to demonstrate that clinical efficacy is not compromised if anatomically favorable positioning is achieved without supporting physiologic evidence. In this proposal we aim to develop and validate a delivery system that is optimized for implantation of DBS electrodes with MR guidance. We will partner with Surgi-Vision, Inc, a small California-based company whose mandate is to harness the power of MR imaging to drive the next generation of minimally invasive surgeries. We propose to develop a delivery system and validate its performance initially in phantom models and subsequently in patients receiving DBS therapy for movement disorders. Efficacy will be evaluated based on both technical (implantation accuracy) and clinical (benefits of stimulation) measures. The specific aims of this proposal are as follows...
Specific Aims. Under this contract, the Awardee shall conduct a project as outlined in the specific aims of the application submitted titled: “Insert Project Title” and on file in the AASM Foundation’s National Office. Awardee will use its reasonable best efforts to conduct this project in accordance with generally accepted professional standards.
Specific Aims. Summarize the objectives of the planned research, including questions to be addressed and/or hypotheses to be tested.
Specific Aims. 1. To obtain the crystal structure of FGF4 bound to its highest affinity receptor, FGFR2.
Specific Aims. The main objective of the work that will be supported by this supplemental funding is to expedite availability of ESS by performance of a limited study (8-10 subjects) under an Investigational Device Exemption (IDE) protocol, with ESS generated by the commercial manufacturer, Lonza Walkersville, Inc (LWI). ESS remains an investigative device which has been studied previously as described above. Toward these objectives, two specific aims are proposed:
