Conference Call Information. Infinity will host a conference call today, Wednesday, July 18, 2012, at 8:30 a.m. ET to discuss the agreement and provide an update on it PI3K program. A live webcast of the conference call can be accessed in the “investors/media” section of Infinity’s website at xxx.xxxx.xxx. To participate in the conference call, please dial 0-000-000-0000 (domestic) or 0-000-000-0000 (international) five minutes prior to start time. An archived version of the webcast will be available on Infinity’s website for 30 days. About Infinity Pharmaceuticals, Inc. Infinity is an innovative drug discovery and development company seeking to discover, develop and deliver to patients best-in-class medicines for diseases with significant unmet need. Infinity combines proven scientific expertise with a passion for developing novel small molecule drugs that target emerging disease pathways. Infinity’s programs focused on the inhibition of the heat shock protein 90, phosphoinositide-3-kinase and fatty acid amide hydrolase are evidence of its innovative approach to drug discovery and development. For more information on Infinity, please refer to the company’s website at xxx.xxxx.xxx.
Conference Call Information. The Medicines Company and Alnylam will host a conference call today at 8:30 a.m. ET to discuss this new collaboration. To access the call, please dial 000-000-0000 (domestic) or 000-000-0000 (international) five minutes prior to the start time and refer to conference ID 96998933. A replay of the call will be available beginning at 11:30 a.m. ET. To access the replay, please dial 000-000-0000 (domestic) or 000-000-0000 (international) and refer to conference ID 96998933. A live audio webcast of the presentation will be available on The Medicines Company website at xxx.xxxxxxxxxxxxxxxxxxx.xxx, and on the News & Investors section of the Alnylam’s website, xxx.xxxxxxx.xxx About Hypercholesterolemia Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood which is known to increase the risk of coronary artery disease, the leading cause of death in the U.S. Some CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT UNDER RULE 24b-2 OF THE SECURITIES EXCHANGE ACT OF 1934. forms of hypercholesterolemia can be treated through dietary restrictions, lifestyle modifications (e.g., exercise and smoking cessation) and medicines such as statins. However, a large proportion of patients with hypercholesterolemia are not achieving target LDL-C goals with statin therapy, including genetic familial hypercholesterolemia patients, acute coronary syndrome patients, high-risk patient populations (e.g., patients with coronary artery disease, diabetics, symptomatic carotid artery disease, etc.) and other patients that are statin intolerant. Severe forms of hypercholesterolemia are estimated to affect more than 500,000 patients worldwide, and as a result, there is a significant need for novel therapeutics to treat patients with hypercholesterolemia whose disease is inadequately managed by existing therapies. About ALN-PCS ALN-PCS is a systemically delivered RNAi therapeutic targeting the gene proprotein convertase subtilisin/kexin type 9 (PCSK9), a target validated by human genetics that is involved in the metabolism of low-density lipoprotein cholesterol (LDL-C, or “bad” cholesterol). ALN-PCS therapies are PCSK9 synthesis inhibitors that lower levels of both intracellular and extracellular PCSK9, thereby phenocopying the human gen...
Conference Call Information. Blueprint Medicines will host a conference call and live audio webcast for investors at 8:00 A.M. ET today. To participate in the conference call, please dial 000-000-0000 (domestic) or 000-000-0000 (international) and refer to conference ID 63223687. A live webcast of the conference call will be available by visiting the Investors section of Blueprint Medicines' website at xxxx://xx.xxxxxxxxxxxxxxxxxx.xxx. The archived webcast will be available on Blueprint Medicines' website approximately 2 hours after the call and will be available for 30 days following the call.
Conference Call Information. Aegerion will host a conference call today at 8:00 am EST to discuss the Myalept acquisition. To listen to the conference call, dial (000) 000-0000 (international callers dial (000) 000-0000). In addition, the presentation will be webcast live, and may be accessed for up to 30 days following the call, by visiting the “Investors” section of Aegerion’s website, xxx.xxxxxxxx.xxx. An accompanying slide presentation also can be accessed via the “Investors” section of the Aegerion website. THIS EXHIBIT HAS BEEN REDACTED AND IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST. REDACTED MATERIAL IS MARKED WITH [*] AND HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. NOTES TO EDITORS About Generalized Lipodystrophy Generalized lipodystrophy consists of a rare set of syndromes that are inherited or acquired through an autoimmune response and that are characterised by loss of fat tissue, typically from under the skin. The underlying reason is a deficiency in leptin, leading to an inability to store triglycerides in normal fat depots. This often leads to severe insulin resistance and diabetes, severe hypertriglyceridemia along with a concomitant increased risk of acute pancreatitis, and hepatic steatosis, which can lead to cirrhosis. Myalept™ (metreleptin for injection) INDICATION and IMPORTANT SAFETY INFORMATION for Myalept™ (metreleptin for injection) INDICATION Myalept™ (metreleptin for injection) is a recombinant human leptin analog indicated as an adjunct to diet as replacement therapy to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy. LIMITATIONS OF USE • The safety and effectiveness of MYALEPT (metreleptin for injection) for the treatment of complications of partial lipodystrophy or for the treatment of liver disease, including nonalcoholic steatohepatitis (XXXX), have not been established. • MYALEPT is not indicated for use in patients with HIV-related lipodystrophy or in patients with metabolic disease, including diabetes mellitus and hypertriglyceridemia, without concurrent evidence of congenital or acquired generalized lipodystrophy. IMPORTANT SAFETY INFORMATION WARNING: RISK OF ANTI-METRELEPTIN ANTIBODIES WITH NEUTRALIZING ACTIVITY AND RISK OF LYMPHOMA • Anti-metreleptin antibodies with neutralizing activity have been identified in patients treated with MYALEPT. The consequences of these neutralizing antibodies are not well characterized but could include inhibition of end...
Conference Call Information. Management of Polestar and Xxxxx Guggenheim will host an investor conference call on Monday, September 27, 2021 at 9:00 am EDT / 3:00 pm CET to discuss the proposed business combination. The call can be accessed by dialing +1 (833) 470- 1428 (domestic toll-free number) or +0 (000) 000-0000 (international) and providing the conference ID 199774. A replay of the call can be accessed by dialing +0 (000) 000-0000 (domestic toll-free number) or +0 (000) 000-0000 (international) and providing the conference ID 643163#. Alternatively, a webcast of the call can be accessed by visiting xxxxx://xxx.xxxxxxxxxxx.xxx/ with the entry code “drive489”. A replay of the webcast can be accessed by visiting xxxxx://xxx.xxxxxxxxxxx.xxx/nrs/home/#!/?show=d413d154. About Polestar Polestar is a Swedish premium electric performance car brand founded by Volvo Cars and Geely Holding. Established in 2017, Polestar enjoys specific technological and engineering synergies with Volvo Cars and benefits from significant economies of scale as a result. The Company is headquartered in Gothenburg, Sweden, and its vehicles are available and on the road in fourteen active global markets across Europe, North America and China. In 2021, Polestar is expanding into five new markets in the Asia Pacific region. Polestar produces two electric performance cars. The Polestar 1 is a low-volume electric performance hybrid GT with a carbon fiber body, 609 hp, 1,000 Nm of torque and an electric-only range of 124 km (WLTP) – the longest of any hybrid car in the world. The Polestar 2 electric performance fastback is the Company’s first fully electric, high volume car. The Polestar 2 model range includes three variants with a combination of long- and standard range batteries as large as 78 kWh, and dual- and single-motor powertrains with as much as 300 kW / 408 hp and 660 Nm of torque. In the future, the Polestar 3 electric performance SUV is expected to join the portfolio, as well as the Precept – a design study vehicle released in 2020 that is slated for future production. Precept showcases the brand’s future vision in terms of sustainability, digital technology and design. In April 2021, Polestar announced an important goal of creating a truly climate-neutral car by 2030. About Gores Guggenheim, Inc. Gores Guggenheim, Inc. (Nasdaq: GGPI, GGPIW, and GGPIU) is a special purpose acquisition company sponsored by an affiliate of The Gores Group, LLC, founded by Xxxx Xxxxx, and by an affiliate of Guggenheim Capit...
Conference Call Information. The Medicines Company and Alnylam will host a conference call today at 8:30 a.m. ET to discuss this new collaboration. To access the call, please dial 877-312-0000 (xxxxxxic) or 631-813-0000 (xxxxxxational) five minutes prior to the start time and refer to conference ID 96998933. A replay of the call will be available beginning at 11:30 a.m. ET. To access the replay, please dial 855-859-0000 (xxxxxxic) or 404-537-0000 (xxxxxxational) and refer to conference ID 96998933. A live audio webcast of the presentation will be available on The Medicines Company website at www.themxxxxxxxxxxxxxxx.xxx, xxx xx the News & Investors section of the Alnylam's website, www.alnyxxx.xxx Xxxxx Hypercholesterolemia Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood which is known to increase the risk of coronary artery disease, the leading cause of death in the U.S. Some forms of hypercholesterolemia can be treated through dietary restrictions, lifestyle modifications (e.g., exercise and smoking cessation) and medicines such as statins. However, a large proportion of patients with hypercholesterolemia are not achieving target LDL-C goals with statin therapy, including genetic familial hypercholesterolemia patients, acute coronary syndrome patients, high-risk patient populations (e.g., patients with coronary artery disease, diabetics, symptomatic carotid artery disease, etc.) and other patients that are statin intolerant. Severe forms of hypercholesterolemia are estimated to affect more than 500,000 patients worldwide, and as a result, there is a significant need for novel therapeutics to treat patients with hypercholesterolemia whose disease is inadequately managed by existing therapies. About ALN-PCS ALN-PCS is a systemically delivered RNAi therapeutic targeting the gene proprotein convertase subtilisin/kexin type 9 (PCSK9), a target validated by human genetics that is involved in the metabolism of low-density lipoprotein cholesterol (LDL-C, or “bad” cholesterol). ALN-PCS therapies are PCSK9 synthesis inhibitors that lower levels of both intracellular and extracellular PCSK9, thereby phenocopying the human genetics observed in loss of function or null human PCSK9 mutations (N. Engl. J. Med. (2006) 354:1264-1272; Am. J. Hum. Genet. (2006) 79: 514-523). PCSK9 synthesis inhibition through an RNAi mechanism has the potential to lower tissue and circulating plasma PCSK9 protein levels resulting in higher LDL receptor levels in the liv...
Conference Call Information. Momenta will host a conference call for investors today at 10 am ET to discuss this important biosimilars collaboration with Mylan. The conference call will be webcast live and a link to the webcast may be accessed on the “Investors” section of the company’s website, xxx.xxxxxxxxxxxxx.xxx. Please go to the site at least 15 minutes prior to the call to register, Confidential Portions of this Exhibit marked as [***] have been omitted pursuant to a request for confidential treatment and have been filed separately with the Securities and Exchange Commission. 108 Confidential Treatment Requested by Momenta Pharmaceuticals, Inc. download, and install any necessary software. An archived version of the webcast will be posted on the Momenta website approximately two hours after the call. To access the call you may also dial (000) 000-0000 (domestic) or (000) 000-0000 (international) prior to the scheduled conference call time and provide the access code 21610391. A replay of the call will be available approximately two hours after the conclusion of the call. To access the replay, please dial (000) 000-0000 (domestic) or (000) 000-0000 (international) and provide the access code 21610391.
Conference Call Information. Management will host a conference call today, Wednesday, February 10, 2016 at 4:45 p.m. Eastern Time to discuss the transaction. Interested investors are invited to participate as follows: · Via Conference Call: Toll-Free: (000) 000-0000; International: (000) 000-0000 · Conference Call Replay: A recording will be available until February 17, 2016 at the following numbers: Toll-Free (000) 000-0000; International (000) 000-0000; Pass code 00000000 · Webcast: A live audio webcast will be accessible at xxx.xxxxxx-xxxxxx.xxx.
Conference Call Information. Neurocrine Biosciences will provide further commentary on the collaboration during its presentation at the Evercore ISI 2nd Annual HealthCONx Conference at 8:45 a.m. EST on Tuesday, December 3, 2019. Today, Xenon will host a conference call at 8:30 a.m. EST to provide commentary on the collaboration. To access the call, please dial (000) 000-0000, or (000) 000-0000 for international callers, and provide conference ID number 3665957. Live audio webcasts of these presentations will be available under “Investors” on the companies’ respective websites at: xxx.xxxxxxxxxx.xxx and xxx.xxxxx-xxxxxx.xxx. A replay of the webcast will be available for each presentation approximately one hour after the conclusion of each event and will be archived for approximately one month. About XEN901 Program for Epilepsy XEN901 is a potent, highly selective Nav1.6 sodium channel inhibitor being developed to treat pediatric patients with SCN8A developmental and epileptic encephalopathy (SCN8A-DEE) and other potential indications, including adult focal epilepsy. A Phase 1 clinical trial was completed using a powder-in-capsule formulation of XEN901 in healthy adult subjects. Xenon has developed a pediatric-specific, granule formulation of XEN901, and juvenile toxicology studies to support pediatric development activities have recently been completed. About Neurocrine Biosciences Neurocrine Biosciences (Nasdaq: NBIX) is a neuroscience-focused, biopharmaceutical company with more than 25 years of experience discovering and developing life-changing treatments for people with serious, challenging and under-addressed neurological, endocrine and psychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia and endometriosis* and clinical development programs in multiple therapeutic areas including Xxxxxxxxx'x disease, chorea in Huntington disease, congenital adrenal hyperplasia, uterine fibroids* and polycystic ovary syndrome*. Headquartered in San Diego, Neurocrine Biosciences specializes in targeting and interrupting disease-causing mechanisms involving the interconnected pathways of the nervous and endocrine systems. For more information, visit xxxxxxxxxx.xxx, and follow the company on LinkedIn. (*in collaboration with AbbVie) About Xenon Pharmaceuticals Inc. Xenon Pharmaceuticals (Nasdaq: XENE) is a clinical stage biopharmaceutical company committed to developing innovative therapeutics to improve the lives of patients with neurological...
Conference Call Information. Alnylam and Isis will host a conference call on September 7, 2007 at 8:30 a.m. ET to discuss the formation and launch of Regulus Therapeutics. The call may be accessed by dialing 800-000-0000 (domestic) or 600-000-0000 (international) five minutes prior to the start time, and providing the passcode 44818346. A replay of the call will be available from 10:30 a.m. ET September 7, 2007 until September 13, 2007. To access the replay, please dial 800-000-0000 (domestic) or 617-801-6888 (international), and provide the passcode 11989900. A live audio webcast of the call will be available on Isis’ website at wxx.xxxxxxxxx.xxx and on the “Investors” section of the Alnylam’s website, wxx.xxxxxxx.xxx, and on Regulus’ website at wxx.xxxxxxxxx.xxx. An archive of the webcast will be available on the both companies’ websites approximately two hours after the event. About microRNA microRNAs (miRNAs) are a recently discovered class of genetically encoded small RNAs, approximately 20 nucleotides in length, and are believed to regulate the expression of a large number of human genes. mxXXX therapeutics represent a new approach for the treatment of a broad range of human disease When inappropriately encoded, miRNAs represent potential disease targets whose selective antagonism can result in the correction of an entire disease pathway in a manner unachievable by today’s medicines. In fact, the inappropriate absence or presence of specific mxXXX molecules in various cells has been shown to be associated with specific human diseases including cancer, viral infection, and metabolic disorders. About Regulus Regulus Therapeutics LLC is a biopharmaceutical company formed to discover, develop and commercialize mxXXX therapeutics. The company was created as a joint venture between Alnylam Pharmaceuticals, a leader in RNAi therapeutics, and Isis Pharmaceuticals, a leader in antisense technologies and therapeutics. Isis and Alnylam scientists and collaborators were the first to discover mxXXX antagonist strategies that work in vivo in animal studies (Kxxxxxxxxx et al. (2005) Nature 438, 685-689; Esau et al. (2006) Cell Metab., 3, 87-98). Isis and Alnylam have also created and consolidated key IP believed by the companies to be required for development and commercialization of mxXXX therapeutics. The company, founded in 2007, maintains facilities in Carlsbad, California. For more information, visit wxx.xxxxxxxxx.xxx. About Alnylam Pharmaceuticals Alnylam is a biopharmaceutical company d...
