Animal Studies. 2.1. Should warm-blooded animals be used in the Sponsored Research, MSK will comply with the applicable portions of the Animal Welfare Act (P.L. 99-158) and will follow the guidelines prescribed in the Public Health Services Policy on Humane Care and Use of Laboratory Animals.
Animal Studies. Stanford does not conduct animal studies that are intended to support applications for research or marketing permits for FDA-regulated products (as described in Title 21, Code of Federal Regulations (CFR) Part 58-Good Laboratory Practice (GLP) for Nonclinical Laboratory Studies).
Animal Studies. If any Work Package includes studies using animals, such activities must comply with applicable laws as well as CEPI’s Animals in Research Policy. Upon request by Awardee, CEPI shall provide further guidance on CEPI funded animal studies promptly so that no delay in the agreed Project timelines occurs.
Animal Studies. Awardee shall pursue studies involving animals as described in the iPDP, in compliance with all applicable laws and regulations and further in compliance with Clause 11.2.
Animal Studies. If the Services involve any animal studies or the handling of animals at FIU facilities, the Services shall only be performed after approval by FIU Institutional Animal Care and Use Committee (IACUC) and only in accordance with such approval.
Animal Studies. Institution does not conduct animal studies that are intended to support applications for research or marketing permits for FDA-regulated products (as described in Title 21, Code of Federal Regulations (CFR) Part 58-Good Laboratory Practice (GLP) for Nonclinical Laboratory Studies).
Animal Studies. A written report for AEs for animal studies which suggest a potential significant risk for humans taking the Product shall be forwarded to the other Party via fax within two (2) Business Days of receipt by the Party making the report.
Animal Studies. Each Partner shall pursue any studies involving animals as described in any Work Package, in compliance with all applicable laws and regulations and further in compliance with Clause 12.
Animal Studies. No CyberKnife System shall be made available for animal studies by CyberHeart at a facility owned, controlled, or used by Accuray, or to which Accuray has access or rights to use (“Accuray Facility”). The Parties acknowledge that CyberHeart is free to continue to use a CyberKnife System under any agreement in effect as of the date hereof and to negotiate access to any CyberKnife System located at a facility that is not an Accuray Facility for the purpose of conducting animal studies and Accuray agrees to provide reasonable support and not to object to any arrangements made by CyberHeart with a third party for such access.
Animal Studies. A prodigious number of studies have examined the impact of the gaseous pollutants of interest in animal models, studies utilised mainly rats and mice, but also other animals such as rabbits, sheep and dogs with the bulk of these studies occurring in the 60’s and 70’s (detailed reviews can be found by Xxxxxxx [118] and Xxxxx [244]) and clearly demonstrate that most studies have employed concentrations outside the typical ambient range. A comparison of the two gaseous pollutant’s effects reveals that O3 can cause greater toxicological effects in the respiratory tract at lower doses [245]. The magnitude of their contrast is study dependent, though a 10-20 fold concentration difference is often cited [59]. In terms of site of action, NO2 effects are more localized in the centriacinar region, while O3 effects can extend more peripherally to include the entire alveolar duct and associated alveoli [245]. In contrast, the site of PM deposition is size dependent (as it was shown in Figure 4) and its toxic effects are heterogeneous and depend on its size and composition, with smaller (fine, ultra fine) city derived particles causing greater toxicological responses [243]. Despite compositional differences of the aforementioned pollutants, they are characterized by two common interrelated toxicological responses following exposure. Specifically, proinflammatory responses can be induced leading to increased permeability and oedema due to disruption of the respiratory epithelial barrier, processes which in turn are thought to be driven by the pollutant’s oxidative properties [246-248].
