General Comment definition

General Comment means a comment prepared by the Committee under rule 77 of its rules of procedure,
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General Comment. The milestones are presented in a sequential way. In reality, they are, to a considerable degree, prepared and executed in parallel. Investments in the project are firstly done by Esperion and then by the SIDF loan, the latter investment never exceeding the amount of the former. Esperion AB /s/ Xxxxx X. Xxxxxx --------------------- Xxxxx X. Xxxxxx /s/ Hans Ageland --------------------- Hans Ageland Enclosure 1. Relevant non-clinical data Anti-atherosclerosis: The object of this study (Shah et. al , Circ. 1998) was -------------------- to test the hypothesis that rApoA-IM/PL would inhibit aortic atherosclerosis induced by cholesterol feeding in atherosclerosis-prone mice. ApoE deficient mice received injections of rLpA-IM/PL every other day for 5 weeks (40 mg/kg), resulting in a significant inhibition of atherosclerosis development Refer to Study Summary Table 1. --------------------------------------------------------------------------------------------------------- Study Summary Table 1. Inhibition of atherosclerosis development in apoE KO mice. --------------------------------------------------------------------------------------------------------- Shah et al. Control Mice Treated Mice* ------------------------------------------------------------------------- 20 weeks 25 weeks 25 weeks (n = 8) (n = 7) (n = 15) --------------------------------------------------------------------------------------------------------- Aortic atherosclerosis 11 + or - 1 17 + or - 5 11 + or - 1 --------------------------------------------------------------------------------------------------------- Lipid content 22 + or - 8 32 + or - 6 13 + or - 8 --------------------------------------------------------------------------------------------------------- Macrophage content 10.8 + or - 2 13.2 + or - 6 5.8 + or - 2.9 --------------------------------------------------------------------------------------------------------- *18 injections of rApoA-I/PL per animal during weeks 20-25 + or - plus or minus Anti-restenosis (1): the object of this study (Amelie et al, Circulation, 1994) ------------------- was to determine whether rApoA-IM/PL confers vascular protective effect after balloon injury, i.e. prevents restenosis. Cholesterol-fed rabbits received doses of 40 mg of rApoA-IM/PL complex every other day for 5 days before and 5 days after balloon injury. The rApoA-IM/PL complex significantly reduced intimal thickening and macrophage content after balloon injury, compared with controls....
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General Comment. “Residual” as used in the SOW refers to pentachlorophenol (PCP)-contaminated soil remaining in the designated removal area following the initial phase of soil excavation and follow-up treatment of such soil beneath the water table using in-situ chemical oxidation. “Residual” is not intended to classify the contamination to be consistent with any definitions under CERCLA or RCRA regulations. DEQ acknowledges EPA’s assertion that contamination must be assessed for the potential to impact the in-water CERCLA remedy for the Portland Harbor Superfund Site (PHSS). While the goal of the proposed work under the PPA is not to achieve source control, the work completed by RestorCap will help support a future Source Control Evaluation under the JSCS. DEQ has attempted to clarify the language concerning source control and manage expectations regarding the source control benefits yielded by the RestorCap PPA SOW. Enclosure B - Primary Comments
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Examples of General Comment in a sentence

  • UN Committee Economic, Social and Cultural Rights, General Comment No. 14 on the right to health, para.

  • This is e.g. stated in General Comment No. 28 of the UNHRC on Equality of rights between men and women.amount to inhuman or degrading treatment.

  • Preamble CRPD; Committee on the Rights of Persons with Disabilities, General Comment No. 1, para.

  • UNHRC, General Comment No. 28 on the Equality of Rights Between Men and Women, para.11; See also CCPR/CO.70/ARG, para.

  • In addition to those rights, it is important to highlight that children have specific rights as enshrined in Article 24 of the EU Charter and in the United Nations Convention on the Rights of the Child (further elaborated in the UNCRC General Comment No. 25 as regards the digital environment), both of which require consideration of the children’s vulnerabilities and provision of such protection and care as necessary for their well-being.

  • The UN Human Rights Committee drafted General Comment No. 16 on the interpretation of the right to privacy.

  • Committee against Torture, General Comment No. 2 on the Implementation of Article 2.

  • General Comment No. 14: The Right to the Highest Attainable Standard of Health (Art.

  • UN Committee on Economic, Social and Cultural Rights (CESCR), General Comment No. 14: The Right to the Highest Attainable Standard of Health (Art.

  • Therefore, no modification of the Draft GEIS is required as a result of this General Comment.


More Definitions of General Comment

General Comment means a comment prepared by the Committee under rule 77
Sample 1
General Comment. The Agreement would prevent diversions to the east slope that could support 500,000-1,000,000 peopleBthis loss needs to be addressed as well as the loss of beneficial effects of transmountain diversions on the human environment and the Platte River. Response: As indicated above, the Agreement does not prevent such diversions nor is it within the authority of the United States or within the policy of the United States to prevent such diversions, and thus the impacts stated are beyond the scope of this EA. General Comment: It is our understanding that the following applies to the Agreement: There will be approximately 240,000 average acre-feet of marketable yield remaining in the Aspinall Unit after subordination; that Reclamation and the Fish and Wildlife Service agree that this subordination is a preexisting commitment and not a new Federal action requiring consultation under the Endangered Species Act and that any potential use of the 60,000 acre-feet will be included in the consultation that Reclamation has committed to for the Aspinall Unit under the Endangered Species Act; that the Agreement will remain in effect until terminated by the mutual consent of all parties; and that the Agreement is a permanent adjustment to the Aspinall Unit water rights. Response: The marketable yield from the Aspinall Unit has been estimated at 300,000 acre-feet, including the 60,000 acre-feet of upstream depletion. The Agreement would not change that. However, other issues such as the Endangered Species Act compliance on the Aspinall Unit and the quantification of the reserved water right for the Black Canyon of the Gunnison National Park could affect this yield. The depletion amount will be included in the upcoming consultation on the operation of the Aspinall Unit under the Endangered Species Act. As presently drafted, the terms of the Agreement would remain in full force until terminated by mutual consent of the parties. Reclamation intends to have this language remain in the Agreement. Concerning a permanent adjustment to the Aspinall Unit water rights, Reclamation has the discretion of signing or not signing the Agreement; but it does not have discretion in allowing the depletion based on Court decisions. An addendum to the water rights for the Aspinall Unit may be needed.
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General Comment. The Agreement represents selective subordination which is not allowed by Colorado law. Response: Findings in District Court, Water Division 4, Case No. 88-CW-178 were that Reclamation=s policy in this case is not a selective subordination under the facts of that case. General Comment: The EA needs alternatives that would protect upstream junior water users not only from Aspinall Unit calls, but also from downstream senior water rights (for example the Redlands senior right, the Gunnison Tunnel, or others). Response: The need for the Agreement was defined in the draft EA in this manner: AA written agreement is needed to formalize the long-standing commitment implementing the depletion allowance that was made by the United States prior to construction of the Unit.@ This commitment did not include protection from downstream senior water right calls and an alternative to provide protection from such calls is outside the scope of this EA and was not included in the EA. General Comment: The Agreement appears to create procedural complexities that could result in water users having to pay the District substantial amounts for administering what has been Ahassle free@ in the past and at no cost. Response: A need exists to monitor and account for the amount of depletions as basin water development continues. This service will be provided by the District. The actual cost of this service may be passed on to the benefitting water users. General Comment: Do the Upper Gunnison Water Conservancy District=s existing rights benefit from the depletion allowance? Would the District=s development of their rights Ause up@ the benefits of the subordination leaving little for other water users? How is the second fill right for Xxxxxx Park Reservoir affected? Response: The District=s rights and the Aspinall Unit rights have identical priority dates. In cases where there exists a water supply shortage, both rights would normally experience a proportional shortage. In these cases the District=s rights could still utilize water, and a portion of the District=s depletion would be counted against the depletion allowance, and thus would benefit. The second fill of Xxxxxx Park would not be affected, but some depletions associated with the second fill could apply against the 60,000 acre-foot depletion allowance.
Sample 1
General Comment. How would any remaining benefits of subordination be allocated? Response: The allocation would occur under the State of Colorado water right policies and laws and would not involve Reclamation.
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General Comment. A binding commitment is needed concerning consultation under the Endangered Species Act (ESA) for the Aspinall Unit, and a discussion about handling future depletions under the ESA is needed. Response: Additional wording has been added to the EA on compliance with the ESA. Reclamation intends that the upcoming consultation on the Aspinall Unit will address this depletion along with operation changes of the Aspinall Unit. Future depletions beyond the 60,000 acre-feet, if they occur, would not fall under the Aspinall Unit consultation nor would they be the responsibility of Reclamation unless there was a Reclamation water contract or some other Reclamation connection involved. General Comment: The cumulative depletion of 60,000 acre-feet does have an environmental impact that needs to be acknowledged in the EA, especially the impact of future depletions. The Fish and Wildlife Service should be consulted on the proposal under the Fish and Wildlife Coordination Act of 1934 and the importance of the administration and protection of instream flow rights in the basin and the filing of new rights should be communicated to the Colorado Water Conservation Board.
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General Comment. 3: Comment has been incorporated into Section 5.2, paragraph 4.
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Related to General Comment

  • Planning Submission or “CAPS” or “Community Accountability Planning Submission” means the HSP Board approved planning document submitted by the HSP to the LHIN. The form, content and scheduling of the Planning Submission will be identified by the LHIN;

  • Commission Comments means written comments pertaining solely to Rule 415 which are received by the Company from the Commission, and a copy of which shall have been provided by the Company to the Holder, to a filed Registration Statement which limit the amount of shares which may be included therein to a number of shares which is less than such amount sought to be included thereon as filed with the Commission.

  • Information Commissioner means the UK Information Commissioner and any successor;

  • Low Impact Development or “LID” means a site design strategy that maintains, mimics or replicates pre- development hydrology through the use of numerous site design principles and small-scale treatment practices distributed throughout a site to manage runoff volume and water quality at the source.

  • Project Management Plan means the management plan that (i) sets out a high level workplan to describe the manner in which the Design-Builder will manage the Project, including to address related matters such as traffic management and communications, and (ii) is prepared by or for the Design-Builder and submitted to the Owner;

  • Urban Coordinating Council Empowerment Neighborhood means a neighborhood given priority access to State resources through the New Jersey Redevelopment Authority.

  • Virginia Stormwater Management Program authority or "VSMP authority" means an authority approved by the State Board after September 13, 2011, to operate a Virginia Stormwater Management Program.

  • input means any goods other than capital goods used or intended to be used by a supplier in the course or furtherance of business;

  • Community Accountability Planning Submission means the HSP Board approved planning document submitted by the HSP to the LHIN. The form, content and scheduling of the Planning Submission will be identified by the LHIN;

  • Team means a team affiliated to a Club, including where a Club provides more than one team in the Competition in accordance with the Rules.

  • Comment means the findings and recommendations of the Council for- mally provided in writing to the head of a Federal agency under section 106.

  • Forest management plan means a written plan prepared and signed by a qualified forester that prescribes measures to optimize production, utilization, regeneration, and harvest of timber. The forest management plan shall include a schedule and timetables for the various silvicultural practices used on forestlands, which shall be a maximum of 20 years in length. A forest management plan shall include all of the following:

  • Air Standards Manager means the Manager, Human Toxicology and Air Standards Section, Standards Development Branch, or any other person who represents and carries out the duties of the Manager, Human Toxicology and Air Standards Section, Standards Development Branch, as those duties relate to the conditions of this Certificate.

  • City’s Manager means a manager who at the relevant time carries such designation from the City under, or in accordance with, ARTICLE 5;

  • Pest Management Plan and “PMP” means the Recipient’s plan dated December 13, 2010, which: (i) addresses the concerns relating to the Project risks associated with potential increases in the use of pesticides for agricultural production, intensification and diversification and controlling disease vector populations arising from irrigation schemes; (ii) sets forth mitigation and monitoring measures to be taken during Project implementation and operation to eliminate adverse environmental and social impacts, offset them, or reduce them to acceptable levels; (iii) recommends institutional measures to strengthen national capacities to implement the mitigation and monitoring measures; and (iv) as part of the implementation arrangements, identifies national agencies and other partners that could play a vital role in the success of the Project.

  • Spatial Planning and Land Use Management Act means the Spatial Planning and Land Use Management Act, 2013 (Act 16 of 2013);

  • Public safety officer means a member serving a public

  • Feedback means input regarding the SAP Products, services, business or technology plans, including, without limitation, comments or suggestions regarding the possible creation, modification, correction, improvement or enhancement of the SAP Products and/or services, or input as to whether Partner believes SAP’s development direction is consistent with their own business and IT needs.

  • Training Plan means the plan that outlines what training and assessment will be conducted off-the-job and what will be conducted on-the-job and how the Registered Training Organisation will assist in ensuring the integrity of both aspects of the training and assessment process.

  • Stormwater management plan means the set of drawings and other documents that comprise all the information and specifications for the programs, drainage systems, structures, BMPs, concepts and techniques intended to maintain or restore quality and quantity of stormwater runoff to pre-development levels.

  • National Medical Support Notice or “NMSN” shall mean a notice that contains the following information:

  • Natural Resources Assistance Council means the natural resources assistance council created pursuant to Ohio Revised Code Section 164.21 as well as its members and officers.

  • Procurement Plan means the Recipient’s procurement plan for the Project, dated April 2, 2010, and referred to in paragraph 1.16 of the Procurement Guidelines and paragraph 1.24 of the Consultant Guidelines, as the same shall be updated from time to time in accordance with the provisions of said paragraphs.

  • Virginia Stormwater Management Program or “VSMP” means a program approved by the State Board after September 13, 2011, that has been established by a locality to manage the quality and quantity of runoff resulting from land-disturbing activities and shall include such items as local ordinances, rules, permit requirements, annual standards and specifications, policies and guidelines, technical materials, and requirements for plan review, inspection, enforcement, where authorized in this article, and evaluation consistent with the requirements of this article and associated regulations.

  • Leader means the person vested from time to time (in accordance with law and the applicable constitutional arrangements) with the political leadership, for the purposes of this Agreement, of each of the London Local Authorities listed in Part 1 of Schedule 1

  • Technical Direction means developing work statements, determining parameters, directing other Contractors' operations, or resolving technical controversies.