Abstract. 10. The month at which the participant joined the consortium, month 1 marking the start date of the project, and all other start dates being relative to this start date.
Abstract. Seller agrees to deliver to Buyer for its examination an abstract of title covering the above described real estate continued to the date of this Agreement and showing marketable title in Seller in accordance with Iowa Title Standards, subject only to the matters permitted by this Agreement. Upon receipt of the continued abstract Buyer shall have 14 days within which to notify Seller in writing of any objections to title. If no written objections are made within this time then title shall be deemed approved for all purposes under this Agreement. Seller will make reasonable efforts to cure any title exceptions caused by its acts or omissions but will not be obligated to cure any other exceptions.
Abstract. This is a survey of the historical development of the Spectral Xxxx- dard Model and beyond, starting with the ground breaking paper of Xxxxx Xxxxxx in 1988 where he observed that there is a link between Xxxxx fields and finite noncommutative spaces. We present the impor- tant contributions that helped in the search and identification of the noncommutative space that characterizes the fine structure of space- time. The nature and properties of the noncommutative space are arrived at by independent routes and show the uniqueness of the Spec- tral Standard Model at low energies and the Pati–Salam unification model at high energies. 1 Introduction 2 2 Early days of the spectral Standard Model 4
Abstract. Increasing concerns about sustainable development and the growth of urban areas have brought forth in recent years a renewed enthusiasm and need for the use of quantitative models in the field of transportation and spatial planning. This project will improve urban simulation models and their interaction with transport models. Unified operational models that favour a microscopic approach, such as UrbanSim and ILUTE (Integrated Land Use, Transportation, and Environment Modelling System) have recently gained a lot of interest both in the land use and transport communities. Nevertheless, in their current forms these models still require further development to support a comprehensive analysis of the main environmental and socio-economic questions of the sustainability of urban growth and the relevant public policies. The goal of this project is to address the modelling and computational issues of integrating modern mobility simulations with the latest micro-simulation land use models. The project will advance the state-of-the-art in the field of the micro- simulation of prospective integrated models of Land-Use and Transport (LUTI). On the modelling side, the main challenges are to integrate a demographic evolution module, to add an environmental module, to improve the overall consistency and, last but not least, to deal with the multi-scale aspects of the problem: several time horizons and spatial resolutions are involved. Theoretical models (such as the monocentric textbook model) have proven useful in stating normative results, but remain of limited usefulness, when it comes to empirical applications that include any degree of disaggregation. However, they are useful benchmarks. Simulation tools are more suitable for dealing with realistic policy analysis. Integrated urban modelling is still a complex task and developing a complete and reliable tool remains out of reach of many professional organizations. The Open Platform for Urban Simulation (OPUS), is an Open Source modelling platform for a suite of behavioural-based models addressing (housing location decisions, employment decisions, and urban form). UrbanSim is an integrated model system implemented within the OPUS Platform. XxxxxXxx has proved to be a very powerful and efficient tool in the context of American cities (Xxxxxxx et al, 2007, Xxxxxxx and Xxxxxxx, 2004). However, various recent projects conducted in Europe (see below) point to the need to adapt the available modelling platform, to develop n...
Abstract. In consideration of intangible assets’ growing importance in deriving the value for many businesses, it is important to account for these assets’ potential tax risks in order to measure their true benefits. One area of tax related to intangible assets under the scrutiny of U.S. transfer pricing and international tax rules is the cost sharing agreement. When related subsidiaries of the same international corporation enter into a cost sharing agreement, they pool their resources together to develop intangible assets for common use. During this process, there are often conflicts between multi-national companies (MNCs) and the Internal Revenue Service (IRS) in assigning the correct amount of how much subsidiaries have to pay one another. Both parties care about this because assigning costs of asset development incorrectly can lead to base erosion and profit shifting behavior for MNCs, affecting both the amount of tax revenue collected by the IRS the and bottom line of MNCs. This thesis examines the causes of this conflict by analyzing court cases between the IRS and different MNCs and synthesizing common conflict points. My results show that potential conflicts between the IRS and MNCs can stem from either the matter of the law or the financial inputs used in modelling the assets’ future costs and benefits. While the IRS has imposed increased vigor on one of these financial inputs, namely the discount rate, it has not addressed other ambiguous legal areas such as those related to stock-based compensation. From a tax perspective, this thesis indicates that there are significant improvements that the IRS can make to clarify its guidance for participants in a CSA. Keywords Transfer pricing, MNC, IRS, cost sharing agreement, intangible asset, stock-based compensation, court cases, profit shifting, discount rate ACKNOWLEDGEMENTS First and foremost, I would like to express my gratitude to my thesis advisor, xxxxxxxxx Xxxxxxxxx Xxxxxxx for her patience and guidance throughout my research process. Her knowledge and advices have helped me adhere to my deadline and produce quality work as a result. Next, I want to thank professor Xxxxxxxx Xxxxxx for looking at my thesis and providing feedbacks from a supply chain perspective. I also want to thank my co-workers at Deloitte Tax in Dallas, as it was through the experience of working with them that inspired me to conduct my thesis in the field of transfer pricing. More specifically, my mentor at Deloitte, Xxxx Xxxxxx helped...
Abstract. At the time of the execution of this Contract, Purchaser acknowledges that the Broker(s) (defined below) have advised and hereby advise Purchaser, by this writing, that Purchaser should have the abstract covering the Property examined by an attorney of Purchaser's own selection or that Purchaser should be furnished with or obtain a policy of title insurance.
Abstract. The introduction of mTOR-inhibitors in transplantation surgery has been asso- ciated with an increase in wound complications. We have previously reported a massive negative effect of everolimus on anastomotic strength in rat intestine at 7 days postoperatively. Because it is clinically important to know if this effect persists and occurs generally, repair in both intestine and abdominal wall has been investigated over a period of 4 weeks. Wistar rats received a daily dose of 1 or 2 mg/kg everolimus orally, from the operation day onwards. Controls re- ceived saline. In each rat a resection of ileum and colon was performed, and end- to-end anastomoses were constructed. On day 7, 14, and 28 the animals were killed and anastomoses and abdominal wall wounds were analyzed, wound strength being the primary parameter. Breaking strength of ileum, colon, and fascia was consistently and significantly reduced in the experimental groups at all time points. Anastomotic bursting pressures followed the same pattern. Loss of strength was accompanied by a decrease in hydroxyproline content after 7 days. Thus, the negative effect of everolimus on wound repair persists for at least 4 weeks after operation in this rodent model. This protracted effect may have clinical consequences and cause surgical morbidity. The number of patients receiving solid organ transplanta- tion is ever increasing. As a consequence, there is a grow- ing number of people who depend on immunosuppressive drugs for transplant survival, not only immediately after operation but also in the long term. Therefore, efforts are aimed at improving immunosuppressive drugs and estab- lish optimal regimens for both purposes. Sirolimus is a lipophilic macrocyclic lactone antibiotic produced from Streptomyces hygroscopicus,1 which binds to the mammalian target of rapamycin (mTOR) and blocks its function. Inhibition of mTOR-mediated path- ways results in arrest of the cell cycle at the G1 phase in various cell types, including T- and B-lymphocytes, and thus constitutes a potent immunosuppressive tool. Ever- olimus, a more recently developed mTOR inhibitor, is very similar to sirolimus in its pharmacodynamic effects.2 Although rapamycin (sirolimus) was already discovered in the 1970s, interest in its use in transplantation surgery originated only a decade ago. The purpose of using mTOR inhibitors was minimizing cyclosporine exposure and avoidance of steroids, because of the relatively strong side effects of the latter ...
Abstract. At the time of the execution of this Agreement, Buyer acknowledges that Agent has advised and hereby advises Buyer, by this writing, that Buyer should have the abstract covering the Property examined by an attorney of Buyer's own selection or that Buyer should be furnished with or obtain a policy of title insurance.
Abstract. INTRODUCTION: The development of fully automated immunoassay platforms has improved the technical reliability of cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease. METHODS: We quantified Aβ1-42, Aβ1-40, tTau and pTau levels using the Lumipulse G System in 94 CSF samples from participants of the SPIN cohort with available 18F- Florbetapir imaging. Amyloid scans were assessed visually and through automated quantification. We determined the cutoffs of CSF biomarkers that optimized their agreement with 18F-Florbetapir PET and evaluated concordance between markers of the amyloid category. RESULTS: Aβ1-42, tTau and pTau (but not Aβ1-40) and the ratios with Aβ1-42 had good diagnostic agreement with 18F-Florbetapir PET. As a marker of amyloid pathology, the Aβ1-42/Aβ1-40 ratio had higher agreement and better correlation with amyloid PET than Aβ1-42 alone. DISCUSSION: CSF biomarkers measured with the Lumipulse G System show good agreement with amyloid imaging. Combination of Aβ1-42 with Aβ1-40 increases the agreement between markers of amyloid pathology.
Abstract. As soon as reasonably possible following the full execution of this Agreement, Seller at its sole cost and expense shall cause to be issued and delivered to Purchaser, abstract of title, or Registered Abstract certified to date to include proper searches covering bankruptcies, and State and Federal judgments and liens. After making that delivery, Seller shall not be obligated for any further updating of the abstracts of title, such further cost to be the sole obligation of the Purchaser.