Xxxxxx Xxxx X. Xxxxxxxx, Xxxxxx X. Xxxxxxxxx, Xxx Xxx, and Xxxxxxx X. X. Xxxx* Abstract: The creation of adaptive matter is heavily inspired by biological systems. However, it remains challenging to design complex material responses that are governed by reaction networks, which lie at the heart of cellular complexity. The main reason for this slow progress is the lack ofa general strategy to integrate reaction networks with materials. Herein we use a systematic approach to preprogram the response of a hydrogel to a trigger, in this case the enzyme trypsin, which activates a reaction network embedded within the hydrogel. A full characterization of all the kinetic rate constants in the system enabled the construction of a computational model, which predicted different hydrogel responses depending on the input concentration of the trigger. The results of the simulation are in good agreement with experimental findings. Our methodology can be used to design new, adaptive materials of which the properties are governed by reaction networks of arbitrary complexity. Living systems are adaptive and use enzymatic reaction networks to detect changes in their environment, process input information, and determine an appropriate response.[1] Materials science has recently taken a keen interest in the adaptivity of living systems,[2] and has created new materials with life-like properties such as self-healing,[3] camouflaging,[4] and control over surface characteristics.[5] Impressive exam- ples include the incorporation of the oscillating Belousov– Zhabotinsky reaction into a self-walking gel,[6] and the work of Xxxxxxxxx and co-workers,[7] who used chemo–mechanico– chemical feedback loops to produce a homeostatic material. Others have pioneered control over hydrogel lifetimes with preprogrammed feedback loops using organic[8] or enzy- matic[9] reactions. However, progress towards “life-like” materials has been slow as we lack a general framework for constructing materials with autonomous behavior and preprogrammed responses to external stimuli. Designing materials with complex responses requires the incorporation of chemical reaction networks, where the kinetics within the system are suitably balanced.[10] Here, we present a systematic approach to program the complex response of hydrogels, inspired by our previous work on enzymatic reaction networks.[11,12] First, we developed a polyacrylamide (PAAm)-based hydrogel that [*] S. G. J. Xxxxxx, I. N. Vialshin, X. X. Xxxxxxxxx, X. Xxx, Pro...
Xxxxxx Xxxx X. Xxxx@xxxx.xxx Xxxxx Xxxxxxxxx X.Xxxxxxxxx@xxxx.xxx Bulgaria: Xxxxxxxx Xxxxxxxxx Xxxxxxxx.Xxxxxxxxx@xxxxxxxxxx.xxx Czech Republic: Xxxxxx Xxxxxxxxxx Wetzlerova Xxxxxxxxxx@xxxx.xx Xxx Xxxxxxxxxxxxx Xxxxxxxxxxxxx@xxxx.xx France: Xxxxxxx Xxxxxxxx Xxxxxxx.Xxxxxxxx@xxxxxxxxxx.xxx Germany:
Xxxxxx Xxxx X. Xxxxxx and Xxxxxxxxx Xxxxxxxx join in this Lease for the sole purpose of subordinating their respective dower and curtesy interest in the Property to the terms and conditions of this Agreement of Lease.
Xxxxxx Xxxx X. Xxxxxx Xxxxx Xxxxxxx If one or more of these arbitrators becomes permanently unable to serve on the panel, the parties shall mutually agree to a replacement(s). Until the parties so agree, the remaining arbitrators shall constitute the panel. When panel membership changes, a new addendum shall be added to the Agreement indicating the change.
Xxxxxx Xxxx X. Xxxxxx Chairman of the Board, President and Chief Executive Officer Agreed to this 24th day of March 1998. XXXXXX X. XXXXXXXXX XX. Xxxxxx X. Xxxxxxxxx, Xx.
Xxxxxx Xxxx X. Xxxxxxxxxx, XX 00000 or to such other address as either party may from time to time designate by notice to the other. Each notice shall be effective when such notice and any required copy are delivered to the applicable address.
Xxxxxx Xxxx X. Xxxxxx, Xxxx Xxxxx, Xxxxx Xxxxxx, Xxxx Xxxxxxx and Xxxxx Xxxxx or knowledge of such persons of facts or circumstances that would lead a prudent person to investigate and, more likely than not, acquire actual knowledge.
Xxxxxx Xxxx X. Xxxxxx Exhibit A-1 FORM OF OPINION OF COMPANY'S GENERAL COUNSEL TO BE DELIVERED PURSUANT TO SECTION 5(b)
Xxxxxx Xxxx X. Xxxxx and J. Xxxxx Xxxxx, stockholders of TPC, have agreed to tender all of their TPC Common Stock pursuant to the Offer.
Xxxxxx Xxxx X. X. Xxxxx and Xxxxxx, P.C. 0000 Xxxxxxxxx Xxxxxxxxx, Xxxxx 000 Xxxxxxx, XX 00000 The fax number is (000)-000-0000 Email: xxxxx@xxxxxxxxxxxxxx.xxx
