United States Uses in Duties and Responsibilities Clause

Duties and Responsibilities from Amended and Restated Employment Agreement

THIS EMPLOYMENT AGREEMENT (this "Agreement") is entered into by and between Conatus Pharmaceuticals Inc., a Delaware corporation (the "Company"), and Daniel L. Ripley ("Employee"), and shall be effective as of January 26, 2017 (the "Effective Date").

Duties and Responsibilities. Employee shall serve as Senior Vice President, Business Development, Program and Alliance Management, of the Company. In the performance of such duties, Employee shall report directly to the CEO and shall be subject to the direction of the CEO and to such limits upon Employee's authority as the CEO may from time to time impose. In the event of the CEO's incapacity or unavailability, Employee shall be subject to the direction of the Board or its designee. Employee hereby consents to serve as an officer and/or director of the Company or any subsidiary or affiliate thereof without any additional salary or compensation, if so requested by the Board or the CEO. Employee's primary place of work shall be the Company's facility in San Diego, California, or such other location within San Diego County as may be designated by the Board or the CEO from time to time. Employee shall also render services at such other places within or outside the United States as the Board or the CEO may direct from time to time. Employee shall be subject to and comply with the policies and procedures generally applicable to employees of the Company to the extent the same are not inconsistent with any term of this Agreement.

Duties and Responsibilities from Employment Agreement

THIS EMPLOYMENT AGREEMENT (this "Agreement") is entered into by and between Zogenix, Inc., a Delaware corporation (the "Company"), and Michael Smith ("Executive"), and shall be effective as of January 16, 2017 (the "Effective Date").

Duties and Responsibilities. Executive shall serve as Executive Vice President and Chief Financial Officer of the Company. In the performance of such duties, Executive shall report directly to the CEO and shall be subject to the direction of the CEO and to such limits upon Executive's authority as the CEO may from time to time impose. In the event of the CEO's incapacity or unavailability, Executive shall be subject to the direction of the Board. Executive hereby consents to serve as an officer and/or director of the Company or any subsidiary or affiliate thereof without any additional salary or compensation, if so requested by the CEO. Executive shall be employed by the Company on a full time basis. Executive's primary place of work shall be the Company's facility in Emeryville, California, or such other locations designated by the CEO from time to time. Executive shall also render services at such other places within or outside the United States as the CEO may direct from time to time. Executive shall be subject to and comply with the policies and procedures generally applicable to senior executives of the Company to the extent the same are not inconsistent with any term of this Agreement.

Duties and Responsibilities from Employment Agreement

THIS EMPLOYMENT AGREEMENT (this "Agreement") is entered into by and between Conatus Pharmaceuticals Inc., a Delaware corporation (the "Company"), and Michelle L. Vandertie ("Employee"), and shall be effective as of March 24, 2016 (the "Effective Date").

Duties and Responsibilities. Employee shall serve as Vice President, Finance, of the Company. In the performance of such duties, Employee shall report directly to the Chief Financial Officer (the "Supervising Officer"), and shall be subject to the direction of the Supervising Officer and to such limits upon Employee's authority as the Supervising Officer may from time to time impose. In the event of the Supervising Officer's incapacity or unavailability, Employee shall be subject to the direction of the CEO or the Board or its designee. Employee hereby consents to serve as an officer and/or director of the Company or any subsidiary or affiliate thereof without any additional salary or compensation, if so requested by the Board, the CEO or the Supervising Officer. Employee's primary place of work shall be the Company's facility in San Diego, California, or such other location within San Diego County as may be designated by the Board, the CEO or the Supervising Officer from time to time. Employee shall also render services at such other places within or outside the United States as the Board, the CEO or the Supervising Officer may direct from time to time. Employee shall be subject to and comply with the policies and procedures generally applicable to employees of the Company to the extent the same are not inconsistent with any term of this Agreement.

Duties and Responsibilities from Employment Agreement

THIS EMPLOYMENT AGREEMENT (this Agreement) is entered into by and between Biocept, Inc., a Delaware corporation (the Company), and Timothy Kennedy (Executive), and shall be effective as of July 25, 2016 (the Effective Date).

Duties and Responsibilities. Executive shall serve as the Chief Financial Officer, Senior Vice President of Operations and Secretary of the Company (CFO). In the performance of such duties, Executive shall report directly to the Chief Executive Officer of the Company (the CEO) and shall be subject to the direction of the CEO and to such limits upon Executives authority as the CEO may from time to time impose. Executives primary place of work shall be the Companys facility in San Diego, California. Executive shall also render services at such other places within or outside the United States as the CEO may direct from time to time. Executive shall be subject to and comply with the policies and procedures generally applicable to senior executives of the Company to the extent the same are not inconsistent with any term of this Agreement.

Duties and Responsibilities from Employment Agreement

This Employment Agreement (this "Agreement") is entered into by and between Biocept, Inc., a Delaware corporation (the "Company"), and Mark G. Foletta ("Executive"), and shall be effective as of August 18, 2015 (the "Effective Date").

Duties and Responsibilities. Executive shall serve as interim Chief Financial Officer of the Company ("CFO"). In the performance of such duties, Executive shall report directly to the Chief Executive Officer of the Company (the "CEO") and shall be subject to the direction of the CEO and to such limits upon Executive's authority as the CEO may from time to time impose. Executive's primary place of work shall be the Company's facility in San Diego, California, or such other location within San Diego County as may be designated by the CEO from time to time. Executive shall also render services at such other places within or outside the United States as the CEO may direct from time to time. Executive shall be subject to and comply with the policies and procedures generally applicable to senior executives of the Company to the extent the same are not inconsistent with any term of this Agreement.

Duties and Responsibilities from Employment Agreement

THIS EMPLOYMENT AGREEMENT (this "Agreement") is entered into by and between Zogenix, Inc., a Delaware corporation (the "Company"), and Gail M. Farfel, Ph.D. ("Executive"), and shall be effective as of June 29, 2015 (the "Effective Date").

Duties and Responsibilities. Executive shall serve as Executive Vice President and Chief Development Officer of the Company. In the performance of such duties, Executive shall report directly to the CEO and shall be subject to the direction of the CEO and to such limits upon Executive's authority as the CEO may from time to time impose. In the event of the CEO's incapacity or unavailability, Executive shall be subject to the direction of the Board. Executive hereby consents to serve as an officer and/or director of the Company or any subsidiary or affiliate thereof without any additional salary or compensation, if so requested by the CEO. Executive shall be employed by the Company on a full time basis. Executive's primary place of work shall be the Company's facility in Emeryville, California, or such other locations designated by the CEO from time to time. Executive shall also render services at such other places within or outside the United States as the CEO may direct from time to time. Executive shall be subject to and comply with the policies and procedures generally applicable to senior executives of the Company to the extent the same are not inconsistent with any term of this Agreement.

Duties and Responsibilities from Amended and Restated Employment Agreement

THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this "Agreement") is entered into by and between Zogenix, Inc., a Delaware corporation (the "Company"), and Stephen J. Farr, Ph.D. ("Executive"), and shall be effective as of April 27, 2015 (the "Effective Date").

Duties and Responsibilities. Executive shall serve as President and Chief Executive Officer of the Company. In the performance of such duties, Executive shall report directly to the Board and shall be subject to the direction of the Board and to such limits upon Executive's authority as the Board may from time to time impose. Executive hereby consents to serve as an officer and/or director of the Company or any subsidiary or affiliate thereof without any additional salary or compensation, if so requested by the Board. Executive shall be employed by the Company on a full time basis. Executive's primary place of work shall be the Company's facility in Emeryville, California, or such other locations as may be designated by the Board from time to time. Executive shall also render services at such other places within or outside the United States as the Board may direct from time to time. Executive shall be subject to and comply with the policies and procedures generally applicable to senior executives of the Company to the extent the same are not inconsistent with any term of this Agreement.

Duties and Responsibilities from Employment Agreement

THIS EMPLOYMENT AGREEMENT (this Agreement) is entered into by and between Conatus Pharmaceuticals Inc., a Delaware corporation (the Company), and David T. Hagerty (Employee), and shall be effective as of October 1, 20141 (the Effective Date).

Duties and Responsibilities. Employee shall serve as Executive Vice President, Clinical Development, of the Company. In the performance of such duties, Employee shall report directly to the CEO and shall be subject to the direction of the CEO and to such limits upon Employees authority as the CEO may from time to time impose. In the event of the CEOs incapacity or unavailability, Employee shall be subject to the direction of the Board or its designee. Employee hereby consents to serve as an officer and/or director of the Company or any subsidiary or affiliate thereof without any additional salary or compensation, if so requested by the Board or the CEO. Employees primary place of work shall be the Companys facility in San Diego, California, or such other location within San Diego County as may be designated by the Board or the CEO from time to time. Employee shall also render services at such other places within or outside the United States as the Board or the CEO may direct from time to time. Employee shall be subject to and comply with the policies and procedures generally applicable to employees of the Company to the extent the same are not inconsistent with any term of this Agreement.

Duties and Responsibilities from Executive Employment Agreement

This EXECUTIVE EMPLOYMENT AGREEMENT (the "Agreement") dated June 3, 2014 (the "Effective Date") by and between Tonix Pharmaceuticals Holding Corp., a company incorporated under the laws of Nevada (the "Company"), and Gregory Sullivan, MD, an individual (the "Executive").

Duties and Responsibilities. Executive shall serve as Chief Medical Officer of the Company. In the performance of such duties, Executive shall report directly to and shall be subject to the direction of the President. Executive shall be employed by the Company on a full time basis. Executive's primary place of work shall be the Company's executive offices in New York, New York, or such other location within the New York City area as may be designated by the Company from time to time. Executive shall also render services at such other places within or outside the United States as the Company may direct from time to time. Executive shall be subject to and comply with the policies and procedures generally applicable to senior executives of the Company to the extent the same are not inconsistent with any term of this Agreement.

Duties and Responsibilities from Executive Employment Agreement

This EXECUTIVE EMPLOYMENT AGREEMENT (the "Agreement") dated April 1, 2014 (the "Effective Date") by and between Tonix Pharmaceuticals Holding Corp., a company incorporated under the laws of Nevada (the "Company"), and Donald J. Kellerman, Pharm.D., an individual (the "Executive").

Duties and Responsibilities. Executive shall serve as the Senior Vice President Clinical Development and Regulatory Affairs of the Company. In the performance of such duties, Executive shall report directly to and shall be subject to the direction of the President. Executive shall be employed by the Company on a full time basis. Executive's primary place of work shall be the Company's branch office in Cupertino, California, or such other location in the San Francisco Bay Area as may be designated by the Board from time to time. Executive shall also render services at such other places within or outside the United States as the Company may direct from time to time. Executive shall be subject to and comply with the policies and procedures generally applicable to senior executives of the Company to the extent the same are not inconsistent with any term of this Agreement.