Substantial Amendment definition

Substantial Amendment means an amendment to the terms of the Clinical Investigation Plan that requires approval by the Research Ethics Committee or is likely to significantly affect the obligations of the Parties in respect of the safety, conduct or management or costs of the Clinical Investigation.

Substantial Amendment means change to the terms of the protocol or any other trial supporting documentation that is likely to have significant impact and affect the safety and integrity of trial participants, the scientific value of the research, the conduct or management of the research, and the quality or safety of any investigational medicinal product used in research.

Substantial Amendment means an amendment to, or the City’s discretionary renewal or extension of:

Examples of Substantial Amendment in a sentence

• If any amendment results in a change in the funding amount, that does not trigger a Substantial Amendment, as defined, Subrecipient Scope of Services, threshold and milestone dates or schedule of activities to be undertaken as part of this Contract, such modifications will be incorporated only by written amendment executed by Director, or designee and Subrecipient.

• The Recipient and the Department shall be governed by the 2008 State of Florida Action Plan Substantial Amendment and applicable State and Federal laws, rules and regulations, including those identified in Attachment B.

• Extensions will be in accordance with the guidelines established in the 2008 State of Florida Action Plan Substantial Amendment.

• Changes to these line items will be reflected in an upcoming Substantial Amendment to the Annual Action Plans as follows: FY 10-11 This Annual Action Plan (AAP) included funding for the Durham Housing Authority’s Community Learning Center of which $48,000.00 was not expended, therefore, this funding is available to reallocate to the Rolling Hills/Southside Infrastructure activity in the same AAP.

• The housing activities to be undertaken with NSP funds are consistent with the Escambia Consortium Consolidated Plan, which means that NSP funds will be used to meet the congressionally identified needs of abandoned and foreclosed homes in the targeted area set forth in the Escambia County NSP Substantial Amendment to its 2008 Annual Plan.

More Definitions of Substantial Amendment

Substantial Amendment means an amendment to a joint economic development zone contract that increases the rate of municipal income tax that may be imposed within the zone, changes the purposes for which municipal income tax revenue derived from the zone may be used, or changes the area or areas included in the zone.

Substantial Amendment means an amendment to a joint

Substantial Amendment means an amendment —

Substantial Amendment means an amendment that materially changes a rate or term

Substantial Amendment means the Town’s NSP Action Plan substantial amendment, required by the NSP regulations, which was approved by HUD on or about December 29, 2008.

Substantial Amendment means an amendment to a joint economic development zone contract that increases the rate of municipal income tax that may be imposed within the zone, changes the purposes for which municipal income tax revenue derived from the zone is used, adds one or more contracting parties, or changes the area or areas included in the zone.

Substantial Amendment means the amendment to the Department’s consolidated plan that must be filed with HUD as a requirement for obtaining HPRP funds outlining how the Department will allocate and utilize HPRP funds.