Thrombocytopenia Sample Clauses

Thrombocytopenia. Kyprolis causes thrombocytopenia with platelet nadirs observed between Day 8 and Day 15 of each 28-day cycle with recovery to baseline platelet count usually by the start of the next cycle. Thrombocytopenia was reported in approximately 40% of patients in clinical trials with Kyprolis. Monitor platelet counts frequently during treatment with Kyprolis. Reduce or withhold dose as appropriate. Hepatic Toxicity and Hepatic Failure: Cases of hepatic failure, including fatal cases, have been reported (< 1%) during treatment with Kyprolis. Kyprolis can cause increased serum transaminases. Monitor liver enzymes regularly. Reduce or withhold dose as appropriate. Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndrome: Cases of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) including fatal outcome have been reported in patients who received Kyprolis. Monitor for signs and symptoms of TTP/HUS. If the diagnosis is suspected, stop Kyprolis and evaluate. If the diagnosis of TTP/HUS is excluded, Kyprolis may be restarted. The safety of reinitiating Kyprolis therapy in patients previously experiencing TTP/HUS is not known. Posterior Reversible Encephalopathy Syndrome (PRES): Cases of PRES have been reported in patients receiving Kyprolis. Posterior reversible encephalopathy syndrome (PRES), formerly termed Reversible Posterior Leukoencephalopathy Syndrome (RPLS), is a neurological disorder which can present with seizure, headache, lethargy, confusion, blindness, altered consciousness, and other visual and neurological disturbances, along with hypertension, and the diagnosis is confirmed by neuro-radiological imaging (MRI). Discontinue Kyprolis if PRES is suspected and evaluate. The safety of reinitiating Kyprolis therapy in patients previously experiencing PRES is not known. Embryo-fetal Toxicity: Kyprolis can cause fetal harm when administered to a pregnant woman based on its mechanism of action and findings in animals. There are no adequate and well-controlled studies in pregnant women using Kyprolis. Kyprolis caused embryo-fetal toxicity in pregnant rabbits at doses that were lower than in patients receiving the recommended dose. Females of reproductive potential should be advised to avoid becoming pregnant while being treated with Kyprolis. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. ADVERSE REACTIONS The most common...
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Thrombocytopenia. For platelets < 75,000/mm3, paclitaxel must be held until platelet count is ³ 75,000/mm3. - If paclitaxel is held for 1 week for platelets < 75,000/mm3, resume paclitaxel at the current dose. - If paclitaxel is held for 2-3 consecutive weeks for platelets < 75,000/mm3, decrease paclitaxel by one dose level for subsequent doses. - If paclitaxel cannot be resumed after holding for 3 consecutive weeks for platelets < 75,000/mm3, discontinue paclitaxel. · For platelets ³ 75,000/mm3 and < 100,000/mm3, continue paclitaxel at the current dose level.
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Thrombocytopenia. In severe HDFN, thrombocytopenia is believed to be caused by increased erythropoiesis as it can suppress the other cell lines and potentially cause leukopenia and thrombocytopenia.85 A retrospective study in our centre showed a 26% incidence of thrombocytopenia (platelet count <150·109/L) in neonates treated with IUT for RhD haemolytic disease. The occurrence of thrombocytopenia was an independent risk factor for perinatal mortality.86 A more recent retrospective observational study was carried out in our centre and also showed a similar incidence of 26% of thrombocytopenia in all neonates with HDFN at birth. Severe thrombocytopenia was found in 6% of neonates. Three risk factors were independently associated with thrombocytopenia at birth: treatment with IUT, being born ‘small-for- gestational-age’ (defined as a birth weight below the 10th percentile) and lower gestational age at birth.87 Thrombocytopenia in HDFN is usually a self-limiting disease, but treatment with platelet transfusions may be needed if platelets drop below transfusion-threshold.
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