Genome-Wide Association Sample Clauses

Genome-Wide Association. Studies (GWAS) In contrast to the hypothesis-driven approach, which characterised previous research in genetics looking at specific genetic loci linked with the disorder, the genome-wide association studies apply an empirical approach searching for an association between common genetic variants (minor allele frequencies of >1%) and the disorder. Through to advances in gene technologies such as microarrays and chips, the GWAS approach brings the possibility to scan millions of single nucleotide polymorphisms (SNPs) across the genome. GWAS use a cross-sectional case-control design to detect which allele variants are more frequent in patients than in controls as markers of a genetic association. The psychiatric Genomic Consortium (PGC) was formed in 2007 with the aim to conduct “mega- analysis” of individual genotype and phenotype data (Xxxxxx, Xxxxxxxx, Xxxx, Xxxxxxx, Xxxxxx, Xxxxxx, Xxxxxx, Xxxxxxxx, et al., 2009; Xxxxxx, Xxxxxxxx, Xxxx, Xxxxxxx, Xxxxxx, Xxxxxx, Xxxxxx, Tzeng, et al., 2009; Xxxxxxxx et al., 2009). The largest mega-analysis conducted by the Schizophrenia Working Group of PGC which combined available schizophrenia GWAS samples (36,989 cases and 113,075 controls) identified 108 specific genetic loci reaching genome-wide significance, 83 of which were novel findings (Xxxxx et al., 2014).
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Related to Genome-Wide Association

  • The Association 1. Upon a request in writing made to the President of a University, the Association or any Chapter thereof shall have the right to meet at such University if appropriate facilities are available. All requests must be received at least twenty-four (24) hours prior to the time requested for the meeting. The parties agree not to schedule meetings involving members of the bargaining unit which would conflict with any previously scheduled meetings or regularly scheduled classes. The parties intend that this provision shall not be deemed to prevent the reasonable scheduling of Association meetings or to permit interference with the normal conduct of University affairs.

  • Hospital-Association Committee (a) There shall be a Hospital-Association Committee comprised of representatives of the Hospital, one of whom shall be the Chief Nursing Officer or designate and of the Association, one of whom shall be the Bargaining Unit President or designate. The number of representatives is set out in the Appendix of Local Provisions and the membership of the Committee may be expanded by mutual agreement.

  • Information to the Association A. Upon prior notice, the Superintendent or designee will make available to the Association information that is available to permit the Association to bargain understandingly and administer this Agreement.

  • Where the Association TEBA, or a School Division have a difference in interpretation of the central and local matters placement list, or where a mediator appointed to support local parties in local bargaining seeks clarification, the difference may be referred in writing to the Transition Committee through the joint chairs.

  • Association Grievance A grievance, as defined in Section 7.1, relating to occurrences actually involving at least three (3) nurses or arising under the Association Representative article, may be initiated by the Association at Step 2 of the above-mentioned procedure by the filing of a written grievance, signed by a representative of the Association, within 35 calendar days from the date of occurrence. Such grievance shall describe the problem and the contract provisions alleged to have been violated.

  • HOME OWNERS ASSOCIATION The Purchaser acknowledges that a Home Owners Association (“HOA”) will be established to regulate, control and manage the common interests of the owners of properties in the development. The Seller will appoint and delegate any or all of its powers and duties in the management of the development to a Managing Agent of its choice. On registration of transfer the Purchaser will become a member of the HOA and be bound by its constitution. The Purchaser specifically acknowledges that he will be liable for levies plus VAT thereon, an estimate of which is detailed in Schedule “A”. The Seller reserves the right to install fibre optic communication or any other data and/or voice communication services in respect of the development as well as a network to serve each individual unit within the development. In the event that the Seller so elects to install the aforesaid communication and network, an additional levy per month shall be imposed upon the owners by the Home Owners Association for these services. The Purchaser specifically acknowledges that he/she will be liable for this additional levy plus VAT thereon, an estimate of which is detailed in Schedule “A”. The Purchaser herewith acknowledges that he has received and read a copy of the draft proposal of the Home Owners Association and understands the contents thereof.

  • HOMEOWNERS ASSOCIATION 9.1 The Purchaser acknowledges that it is anticipated that the Property will fall under the jurisdiction of the HOA, being a new Homeowners’ Association which shall come/came into existence on registration of transfer of the first Erf in the Development from the Seller to a third party purchaser, it being recorded that the HOA is established for the benefit of, inter alia, all of owners of xxxxx in the Development and to control and maintain roads, services and amenities within, inter alia, the Development.

  • Association-Management Committee There shall be an Association-Management Committee comprised of two (2) representatives of the parties. The Committee shall meet quarterly, unless otherwise mutually agreed. Agenda items to be discussed shall be exchanged in writing at least five calendar days prior to the meeting. Meetings of this Committee will be to discuss matters of mutual concern, matters relating to nursing, professional practice, scheduling and work load issues. The Committee shall promote and provide for effective and meaningful communication. The parties agree Self Scheduling is appropriate subject matter to discuss in this forum.

  • Subpoenas Directed to BellSouth Where BellSouth provides resold services or local switching for <<customer_name>>, BellSouth shall respond to subpoenas and court ordered requests delivered directly to BellSouth for the purpose of providing call detail records when the targeted telephone numbers belong to <<customer_name>> end users. Billing for such requests will be generated by BellSouth and directed to the law enforcement agency initiating the request. BellSouth shall maintain such information for <<customer_name>> end users for the same length of time it maintains such information for its own end users.

  • Association Dues 5.01 In every pay period, the Board shall deduct from every pay of each Occasional Teacher the appropriate amount of dues as authorized by the Constitution of the Association and directed by its Executive.

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