Care and Use of Laboratory Animals Sample Clauses

Care and Use of Laboratory Animals. The Recipient must comply with the care and use of laboratory animal standards pursuant to the following:
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Care and Use of Laboratory Animals. The Contractor shall maintain such assurance for the duration of this contract, and any subcontractors performing work under this contract involving the use of animals shall also obtain and maintain an approved Animal Welfare Assurance.
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Care and Use of Laboratory Animals the Federation of Animal Science Societies Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching; any additional Requirements set forth in DHS Directive 026-01 regarding the Care and Use of Animals in Research; Requirements set forth in 45 CFR Part 46, Subparts A-D; DHS Directive 026-04 entitled “Protection of Human Subjects” and any related DHS policies and instructions. Subrecipient shall not initiate any activities contemplated under this Section or execute modifications to any such approved activities until all documentation and forms required by the Grantor pursuant to Requirements set forth in this Section is duly submitted to and approved by the Grantor.
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Care and Use of Laboratory Animals. The Contractor shall maintain such assurance for the duration of this contract, and any subcontractors performing work under this contract involving the use of animals shall also obtain and maintain an approved Animal Welfare Assurance. Portions of this Exhibit were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 406 of the Securities Act. Xxxxx Pharmaceutical Group Contract No. HHSN266200400044 N01-AI-40044 All research involving live, vertebrate animals shall be conducted in accordance with the Public Health Service Policy on Humane Care and Use of Laboratory Animals. This policy may be accessed at xxxx://xxxxxx0.xxx.xxx/grants/olaw/references/phspo1.htm
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Care and Use of Laboratory Animals. All experiments were approved by the Emory Institutional Care and Use Committee. Compounds Drugs used in this study were: reboxetine (Pfizer, Groton, CT), desipramine (Sigma- Xxxxxxx, St. Xxxxx, MO), imipramine (Sigma-Xxxxxxx), bupropion (Sigma-Xxxxxxx), GBR12909 (Sigma-Xxxxxxx) and venlafaxine (Wyeth, Monmouth Junction, MJ). Antidepressant administration Drugs were administered acutely via i.p. injection or chronically via Alzet® osmotic minipumps (Model #2004, 0.25 l/hr, 28 d; Durect, Cupertino, CA). For chronic administration, antidepressants were dissolved in either 0.9% sterile saline (reboxetine, 20 mg/kg/d; imipramine, 120 mg/kg/d; venlafaxine, 20 mg/kg/d; bupropion, 40 mg/kg/d) or an aqueous solution containing 50% ethanol and 0.9% sterile saline (desipramine, 20 mg/kg/d), and loaded into pumps. Doses were chosen to achieve serum levels that fell within or very close to human therapeutic range (Xxxxx et al., 2006). Minipumps containing 0.9% sterile saline or a 50% ethanol/0.9% sterile saline aqueous solution were used as vehicle controls. All pumps were placed in a sterile 37C saline bath for 1 day before implantation. Mice were anesthetized with isoflurane and minipumps were implanted in the intraperitoneal cavity. Buprenorphine (2.5 mg/kg, s.c.) was given immediately following surgery for pain management. For acute administration, all antidepressants were dissolved in vehicle (0.9% sterile saline) except for GBR12909 (1.5% DMSO, 0.9% sterile saline) and injected i.p. as a bolus (10 ml/kg) using the same doses as for the chronic paradigm. The exceptions were (1) imipramine, which caused profound ataxia and sedation when 120 mg/kg was injected acutely, so 20 mg/kg was used instead, and (2) GBR12909 (20 mg/kg), which is not used clinically as an antidepressant and was not tested in the chronic experiment. Locomotor activity testing For acute experiments in a novel environment, drugs were injected i.p. 30 minutes prior to placement in unfamiliar transparent plexiglass cages (40 x 20 x 20 cm) situated in racks with 7 infrared photobeams spaced 5 cm apart, each end beam 5 cm from the cage wall (San Diego Instruments Inc., LaJolla, CA). Activity xxxxxxxx were connected via an interface to a computer, and ambulations (consecutive beam breaks) were recorded. Testing began between 0900-1000 and continued for 2 hours. For chronic experiments in a novel environment, mice were tested, as described above, 18-20 days after minipump implantation. For chronic e...
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Related to Care and Use of Laboratory Animals

  • Payment for Labor and Materials The Contractor agrees and binds itself to pay for all labor done, and for all the materials used in the construction of the work to be completed pursuant to this contract.

  • Fraud, Waste, and Abuse Contractor understands that HHS does not tolerate any type of fraud, waste, or abuse. Violations of law, agency policies, or standards of ethical conduct will be investigated, and appropriate actions will be taken. Pursuant to Texas Government Code, Section 321.022, if the administrative head of a department or entity that is subject to audit by the state auditor has reasonable cause to believe that money received from the state by the department or entity or by a client or contractor of the department or entity may have been lost, misappropriated, or misused, or that other fraudulent or unlawful conduct has occurred in relation to the operation of the department or entity, the administrative head shall report the reason and basis for the belief to the Texas State Auditor’s Office (SAO). All employees or contractors who have reasonable cause to believe that fraud, waste, or abuse has occurred (including misconduct by any HHS employee, Grantee officer, agent, employee, or subcontractor that would constitute fraud, waste, or abuse) are required to immediately report the questioned activity to the Health and Human Services Commission's Office of Inspector General. Contractor agrees to comply with all applicable laws, rules, regulations, and System Agency policies regarding fraud, waste, and abuse including, but not limited to, HHS Circular C-027. A report to the SAO must be made through one of the following avenues: ● SAO Toll Free Hotline: 1-800-TX-AUDIT ● SAO website: xxxx://xxx.xxxxx.xxxxx.xx.xx/ All reports made to the OIG must be made through one of the following avenues: ● OIG Toll Free Hotline 0-000-000-0000 ● OIG Website: XxxxxxXxxxxXxxxx.xxx ● Internal Affairs Email: XxxxxxxxXxxxxxxXxxxxxxx@xxxx.xxxxx.xx.xx ● OIG Hotline Email: XXXXxxxxXxxxxxx@xxxx.xxxxx.xx.xx. ● OIG Mailing Address: Office of Inspector General Attn: Fraud Hotline MC 1300 P.O. Box 85200 Austin, Texas 78708-5200

  • Alcohol and Drug-Free Workplace City reserves the right to deny access to, or require Contractor to remove from, City facilities personnel of any Contractor or subcontractor who City has reasonable grounds to believe has engaged in alcohol abuse or illegal drug activity which in any way impairs City's ability to maintain safe work facilities or to protect the health and well-being of City employees and the general public. City shall have the right of final approval for the entry or re-entry of any such person previously denied access to, or removed from, City facilities. Illegal drug activity means possessing, furnishing, selling, offering, purchasing, using or being under the influence of illegal drugs or other controlled substances for which the individual lacks a valid prescription. Alcohol abuse means possessing, furnishing, selling, offering, or using alcoholic beverages, or being under the influence of alcohol.

  • Laboratory a. Drug tests shall be conducted by laboratories licensed and approved by SAMSHA which comply with the American Occupational Medical Association (AOMA) ethical standards. Upon advance notice, the parties retain the right to inspect the laboratory to determine conformity with the standards described in this policy. The laboratory will only test for drugs identified in this policy. The City shall bear the cost of all required testing unless otherwise specified herein.

  • LABOR AND MATERIALS 3.4.1 Unless otherwise provided in the Contract Documents, the Contractor shall provide and pay for labor, materials, equipment, tools, construction equipment and machinery, water, heat, utilities, transportation, and other facilities and services necessary for proper execution and completion of the Work, whether temporary or permanent and whether or not incorporated or to be incorporated in the Work.

  • Drug-Free Workplace Contractor represents and warrants that it shall comply with the applicable provisions of the Drug-Free Work Place Act of 1988 (41 U.S.C. §701 et seq.) and maintain a drug-free work environment.

  • DRUG AND ALCOHOL FREE WORKPLACE 22.1 All employees must report to work in a condition fit to perform their assigned duties unimpaired by alcohol or drugs. Each institution is required to comply with the Drug-Free Schools and Communities Act (DFSCA) and the Drug-Free Schools and Campuses Regulations in order to be eligible for federal funding.

  • Substance Abuse Treatment Information Substance abuse treatment information shall be maintained in compliance with 42 C.F.R. Part 2 if the Party or subcontractor(s) are Part 2 covered programs, or if substance abuse treatment information is received from a Part 2 covered program by the Party or subcontractor(s).

  • CONTRACT WORK HOURS AND SAFETY STANDARDS As per the Contract Work Hours and Safety Standards Act (40 U.S.C. 3701-3708), where applicable, all Customer Purchase Orders in excess of ,000 that involve the employment of mechanics or laborers must include a provision for compliance with 40 U.S.C. 3702 and 3704, as supplemented by Department of Labor regulations (29 CFR Part 5). Under 40 U.S.C. 3702 of the Act, each contractor must be required to compute the wages of every mechanic and laborer on the basis of a standard work week of 40 hours. Work in excess of the standard work week is permissible provided that the worker is compensated at a rate of not less than one and a half times the basic rate of pay for all hours worked in excess of 40 hours in the work week. The requirements of 40 U.S.C. 3704 are applicable to construction work and provide that no laborer or mechanic must be required to work in surroundings or under working conditions which are unsanitary, hazardous or dangerous. These requirements do not apply to the purchases of supplies or materials or articles ordinarily available on the open market, or contracts for transportation or transmission of intelligence.

  • Laboratory Testing All laboratories selected by UPS Freight for analyzing Controlled Substances Testing will be HHS certified.

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