Analysis of *. Enumeral will obtain * and controls *. Samples will be frozen and stored appropriately. Samples will undergo enrichment as described above based on discussions between Enumeral and Crucell. · Samples will be screened employing the assay conditions developed above; screens will be performed under activated and unactivated (“resting”) conditions · *. Cell surface markers will be enumerated to determine *. · Cell retrieval conditions will be discussed between Crucell and Enumeral. Cells secreting antibodies * will be retrieved using Enumeral’s specialized instrumentation and transferred to 96 well plates for subsequent RT-PCR and sequencing. · Deliverable: Data identifying the frequency of antibodies * as well as * will be presented. Assessment point: Results of the pilot phase will be discussed to determine the appropriate structure for the Patient Phase and serve as a “go/no-go” decision point for the program. Criteria for progressing to Patient Phase should include * antibodies. The decision to continue to the Patient Phase will be made by Crucell upon its sole discretion. In case Crucell decided not to continue to the Patient Phase this SOW and the Agreement shall be deemed to be terminated. Agreement Contract Research Crucell Holland B.V. – Contractor
Analysis of *. APPLICATION AREAS WITH POTENTIAL SPIN-OFFS TOWARDS HD Many technologies that are currently emerging from R&D and new equipment that has reached a certain stage of maturity in other application domains have not yet been brought into relation with humanitarian demining, although they are potentially capable of triggering major breakthroughs. Considering that the market for humanitarian demining equipment is very limited and identifying a lack of interest from large companies in making the considerable investments for developing and productionising the results of R&D, EUDEM2 should be seen as a pro-active measure to identify transferable technologies from other application domains towards humanitarian demining. The existence of this potential has been widely acknowledged by the R&D community on humanitarian demining. Workshops are being organised to bring actors of diverse domains together, but their results stay superficial due to lack of continued effort and co-ordination. Rarely the identified technologies, are analysed in sufficient depth and monitored on a continuous basis. Identification and analysis of mature technologies via direct and repeat interviews of organisations not yet directly related to landmine detection is a major goal of EUDEM2. The project will carry out a broad survey action and issue documented recommendations about the appropriateness to start a more detailed Technology survey for some specific techniques having a very high potential to provoke a major breakthrough in humanitarian demining. Among the areas which will certainly be surveyed we find e.g. non-destructive testing (NdT), airport surveillance, bio-technologies, biological sensors, the agro-alimentary technologies, remote sensing for agriculture and land cover identification, etc. Technologies that are currently in use but at present not financially supported for R&D, will be investigated as well, e.g. mechanical demining, including vegetation cutters, etc. The technology survey activity within EUDEM2 will look for technology that could respond to the several types of mine action activities as specified by the UN (Level 1 surveys, Level 2 surveys and area reduction, mine clearance, Level 3 surveys and Quality Control). Along with the new technologies, EUDEM2 will also actively motivate new players from industry and academia to enter the domain of humanitarian demining. Central is to detect technologies that could lead to significant breakthroughs in both industrial and socie...
