THE LABORATORY. The Laboratory reveals how, over the last thirty years, the design culture of Britain has moved towards an ideas-driven creative economy. The section focuses on the development of design consultancy and new technologies. The British computer games industry thrived while traditional manufacturing was dying and continues to hold an important global position. Britain has nurtured a new generation of international designers working across a range of disciplines. Keyworks: Xxxxxxxx computers, Video Games such as Xxxx Xxxxx and GTA, CDP’s Xxxxxx and Xxxxxx advertising campaign. Digital design and new design technologies.
THE LABORATORY. Our laboratory has a strong multidisciplinary component, which combines Microscopy atomic force with engineering of proteins, structural biology, and molecular dynamics to understand the mechanism of action of proteins. The studies will take place at the Cajal Institute, an institution pioneer and leader of research in down town Madrid. In our laboratory we are interested in understanding the molecular mechanisms responsible for the function of the proteins. Our lines of research are focused on nanomechanics of CPEB (prionoid that controls the consolidation of memory), the neurotoxic proteins (causal agents of neurodegenerative diseases such as Alzheimer or Xxxxxxxxx), proteasome, and scaffolding proteins (notably in the cellulosome). THE FIELD: PROTEIN NANOMECHANICS Proteins are responsible for the vast majority of biological functions and are considered today as bionanomachines whose inner workings are being unveiled using monomolecular techniques (biochemistry of individual molecules). The nanomanipulation is one of them, which allows the application of mechanical forces to individual molecules using mechanical force as a new biochemical parameter. As a result, the protein nanomechanics has emerged in little more than one decade as an extraordinarily active field that studies the mechanical properties of proteins. Atomic force microscopy is one of the most commonly used techniques in the field, a is very useful particularly for the study of proteins that are subject to mechanical stress, with mechanical function and unstructured proteins (such as the neurotoxic proteins or the CPEB prionoid). We combine this technique with the classical techniques of biochemistry, molecular biology, protein engineering, structural biology, cell cultures and animal models as well as molecular dynamics simulations.
