Study population and design Sample Clauses

Study population and design. We studied 259 patients included in the Glycometabolic Intervention as adjunct to Primary percutaneous intervention in ST elevation myocardial infarction (GIPS-III) trial with available CMR and 2D TTE assessments at four months after hospitalization for STEMI. This study is a subanalysis of the GIPS-III trial, a single-center, randomized, placebo-controlled trial, recruiting 380 consecutive patients presenting with a first STEMI between January 1, 2011 and May 26, 2013. Details on the GIPS-III trial have been reported previously [8,9]. In brief, 380 patients were randomized to take either 500 mg metformin or placebo twice daily during a period of four months. Written informed consent was obtained in all participants. One patient withdrew informed consent, leaving 379 patients in the final study. Major exclusion criteria were known diabetes mellitus (as patients with diabetes mellitus already received metformin and could therefore not be randomized), previous myocardial infarction, contraindications for CMR, the need for coronary artery bypass graft surgery, and severe renal dysfunction. The sample size of the study was determined for the primary efficacy measure, which was LVEF as measured by CMR at four months after the index event. Because no significant effect of metformin on LVEF was observed, and elaborate data collection including echocardiograms were obtained in most patients, the study was deemed suitable for further imaging substudies.
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Study population and design. 5 A retrospective cohort study was conducted at the Pediatric Hematopoietic Stem Cell Transplantation unit of the Leiden University Medical Centre (LUMC) from May 2011 until May 2019. The study was approved by the Medical Ethics Review Committee of the LUMC, Leiden. Informed consent was waived by the Medical Ethics Review Committee of the LUMC. All methods were carried out in accordance with relevant guidelines and regulations. Pediatric patients (≤ 18 years) who received treosulfan (TREO)- or busulfan (BU)-based conditioning prior to HSCT were included and divided in two cohorts. Treosulfan was given in a dose of 42 g/m2 and 30 g/m2 in children above or under the age of 1 year old, respectively. Busulfan was initially dosed as 120 mg/m2 and then targeted to a total exposure (as area under the concentration curve, AUC0-∞) of 75-95 mg*h/L. Data retrieval Electronic Health Records (EHRs) were screened anonymously, using the intelligent search engine CTcue Clinical Data Collector (CTcue B.V., Amsterdam, The Netherlands), a software package that can be used to search through Electronic Health Records [16]. The EHR includes records from nurses, physicians, physical therapists, dieticians, social workers and pharmacists. The patient population and data points are defined using CDC queries. Two queries were created; in one patients were included ≤ 18 years of age that have received treosulfan and in the other patients received busulfan between May 2011 and May 2019. Using myalgia and 22 synonyms as keywords (see Supplemental Material 1), patients with one of these keywords mentioned in the EHR until 28 days after HSCT were highlighted. Subsequently, highlighted EHRs were manually checked for validity. Measurement of myalgia and pain severity The presence of myalgia within 28 days after HSCT (i.e. discomfort originating from a muscle or group of muscles) was scored as an event. Time of onset, location and duration of pain were derived manually from the EHR. Duration of pain was derived from the use of pain medication. Additionally, pain severity was categorized according to the World Health Organization (WHO) pain relief ladder: paracetamol (PCM) (step 1), PCM and tramadol (step 2), addition of strong acting opiate (step 3) and addition of adjuvant medicines (e.g. ketamine, clonidine, pregabalin) (step 4). When mucositis was present, EHRs were thoroughly screened to confirm that pain medication was given for myalgia and not for mucositis only. Collection of other ...
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Study population and design. As stated previously, the dataset was collected from a group of patients at the ADCs who were given a multitude of different tests including the MOCA and the MMSE. The dataset consists of both new and returning patients. Ideally, the study would have only consisted of new patients; however, due to time constraints, both tests were given to both new and returning patients.3 For this analysis we are only interested in the study visits during which the Crosswalk study was completed for the first time. If the returning patients have more than one visit, the extra visits will be ignored. Patient recruitment was stratified to ensure the majority of patients were either MCI or mildly demented, with ADCs being instructed to recruit the majority of patients with MMSE scores between 16 and 26 points. No scores below 10 points were included due to the difficulty of administering the tests at that severity of cognitive impairment.3 Each patient received the tests in a random order to ensure no learning effect was present. The authors found that this randomization was successful. More details can be found in Xxxxxxx et al. Statistical Analyses:
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Related to Study population and design

  • Creation and Designation There is hereby created a Tranche of Class A Notes to be issued pursuant to this Terms Document, the Indenture and the Indenture Supplement to be known as the “DiscoverSeries Class A(2018-6) Notes.”

  • Joint Network Implementation and Grooming Process Upon request of either Party, the Parties shall jointly develop an implementation and grooming process (the “Joint Grooming Process” or “Joint Process”) which may define and detail, inter alia:

  • Study Population ‌ Infants who underwent creation of an enterostomy receiving postoperative care and awaiting enterostomy closure: to be assessed for eligibility: n = 201 to be assigned to the study: n = 106 to be analysed: n = 106 Duration of intervention per patient of the intervention group: 6 weeks between enterostomy creation and enterostomy closure Follow-up per patient: 3 months, 6 months and 12 months post enterostomy closure, following enterostomy closure (12-month follow-up only applicable for patients that are recruited early enough to complete this follow-up within the 48 month of overall study duration).

  • Domain and Designation The Top-Level Domain to which this Agreement applies is (the “TLD”). Upon the Effective Date and until the earlier of the expiration of the Term (as defined in Section 4.1) or the termination of this Agreement pursuant to Article 4, ICANN designates Registry Operator as the registry operator for the TLD, subject to the requirements and necessary approvals for delegation of the TLD and entry into the root-zone.

  • DRUG ABUSE DETECTION AND DETERRENCE 2.18.1 It is the policy of the City to achieve a drug-free workforce and workplace. The manufacture, distribution, dispensation, possession, sale, or use of illegal drugs or alcohol by contractors while on City Premises is prohibited. Contractor shall comply with all the requirements and procedures set forth in the Mayor’s Drug Abuse Detection and Deterrence Procedures for Contractors, Executive Order No. 1-31 (the “Executive Order”), which is incorporated into this Agreement and is on file in the City Secretary’s Office.

  • FRAUD PREVENTION AND DETECTION You agree to maintain appropriate security controls and procedures to prevent and detect thefts of Instruments, or losses due to fraud or forgery involving Instruments, or fraudulent or unauthorized Transactions. You agree to diligently supervise and monitor the conduct and work of all agents and employees having any role in the preparation of Your Instruments or conduct of Transactions, Your reconciliation of the statement of account for the Account, or other banking functions.

  • Implementation and Review The Parties shall consult annually, or as otherwise agreed, to review the implementation of this Chapter and consider other matters of mutual interest affecting trade in services. (10) 10 Such consultations will be addressed under Article 170 (Free Trade Commission) of Chapter 14 (Administration of the Agreement).

  • Allocation and use of scarce resources Any procedures for the allocation and use of scarce resources, including frequencies, numbers and rights of way, will be carried out in an objective, timely, transparent and non-discriminatory manner. The current state of allocated frequency bands will be made publicly available, but detailed identification of frequencies allocated for specific government uses is not required.

  • Education and Prevention 6.1 The policy will be discussed and put forward for adoption on site at a meeting of all workers.

  • LOCATION AND DESCRIPTION The subject property is a stratified shop unit bearing postal address of Xxxx Xx. X-00-X, Xxxxxx Xxxxx Xxxxxxx, Xxxxx Xxxxx Sentral 14/KU5, Klang Sentral, Xxxxx Xxxx, Xxxx 00000 Xxxxx, Xxxxxxxx Darul Ehsan. Accommodation:- Verandah, shop area, and water closet. RESERVE PRICE:- The property will be sold on an “as is where is” basis and subject to a reserve price of RM 540,000.00 (RINGGIT MALAYSIA FIVE HUNDRED AND FORTY THOUSAND ONLY) and the Conditions of Sale, herein and by way of an Assignment from the Assignee subject to the necessary confirmations / consent being obtained by the Purchaser from the Developer and/or Proprietor and/or State Authorities and/or relevant bodies, if any is required, including all terms, conditions, stipulations and covenants which were and may be imposed by the Developer and the relevant authority. All expenses incurred in obtaining the said consent shall be borne by the Purchaser. Any arrears of quit rent, assessment, service/maintenance charges, sinking fund including the late payment interest (if any) which may be lawfully due to any relevant authority or the Developer or Proprietor or relevant third parties entitled thereto up to the date of successful sale of the subject property shall be borne out of the purchase money. The Purchaser shall bear and pay all fees and expenses including but not limited to all legal fees, stamp duty and registration fees in connection with, incidental to or pursuant to the Assignment and all other documents necessary for effecting the transfer or assigning the beneficial ownership in the property to the Purchaser and shall also bear all risks in relation to the purchase of the Property. Online bidders are further subject to the Terms & Conditions on xxx.xxxxxxxxxxxxxxxx.xxx. All intending bidders are required to deposit 10% of the fixed reserve price (“the initial deposit”) by way of bank draft or cashier’s order crossed “A/C PAYEE ONLY” made payable to OCBC BANK (MALAYSIA) BERHAD prior to the auction sale or remit the same through online banking transfer, one (1) working day before auction date and pay the difference between the initial deposit and the sum equivalent to 10% of the successful bid price either in cash or bank draft or cashier’s order crossed “A/C PAYEE ONLY” made payable to OCBC BANK (MALAYSIA) BERHAD immediately after the fall of the hammer with the undermentioned Auctioneer. The balance of the purchase price is to be settled within one hundred and twenty (120) days from the date of auction sale to OCBC BANK (MALAYSIA) BERHAD. For online bidders please refer to the Terms & Conditions on xxx.xxxxxxxxxxxxxxxx.xxx on the manner of payment of the deposit. FOR FURTHER PARTICULARS, please apply to Messrs. Xxxxx & Xxxx, Solicitors for the Assignee/Bank, at No. 16-08, Xxxxx 00 Xxxxx, Xxxxxx Xxxxxxx, 000, Xxxxx Xxxxxx Xxxxx Xxxxxx, 50100 Kuala Lumpur. (Ref No: RL/OCBC-LIT(NSec)/00000-0000(1), Tel No: 00-00000000 Fax No: 00- 00000000) or the undermentioned Auctioneer: EHSAN AUCTIONEERS SDN. BHD. (Co. No. 617309-U) DATO’ HAJI XXXXX XXXXX BIN X.X. XXXX (D.I.M.P) Xxxxx X-00-0X, Xxxxx 00, Xxxxx X, Xxxxx Xxxxxx II, / XXXXX XXXXX BIN XXXXXX 00, Xxxxx Xxx Xxxx Xxxx, 50450 Kuala Lumpur (Licensed Auctioneers) Tel No.: 00-0000 0000 Fax No.: 00-0000 0000 Our Ref: XXXXX/OCBC0845/AW(5) Website: xxx.xxxxxxxxxxxxxxxx.xxx E-mail: xxxx@xxxxxxxxxxxxxxxx.xxx HP NO. : 000 0000 000 (CALL, WHATSAPP & SMS) PERISYTIHARAN JUALAN DALAM PERKARA PERJANJIAN KEMUDAHAN (PERBANKAN PERNIAGAAN/ PASARAN MASS ENTERPRISE), SURATIKATAN PENYERAHAN HAK (PIHAK PERTAMA) XXX SURAT KUASA WAKIL (PIHAK PERTAMA) KESEMUANYA BERTARIKH 07HB OGOS, 2014 DI ANTARA OCBC BANK (MALAYSIA) BERHAD (295400-W) PIHAK PEMEGANG SERAHHAK / BANK XXX MH CENTURY PROPERTY HOLDING SDN BHD (No. SYARIKAT: 1085186-P) PIHAK PENYERAHHAK/PIHAK PEMINJAM Menurut kuasa xxx xxx xxxx telah diberikan kepada Pihak Pemegang Serahhak/Bank di bawah perkara Perjanjian Kemudahan (Perbankan Perniagaan/ Pasaran Mass Enterprise), Suratikatan Penyerahan Hak (Pihak Pertama) Xxx Surat Kuasa Wakil (Pihak Pertama) Kesemuanya Bertarikh 07hb Ogos, 2014 di antara Pihak Penyerahhak/Peminjam xxx Pihak Pemegang Serahhak/Bank, xxx berkenaan dengan Perjanjian Jualbeli di antara NPO Development Sdn Bhd (“Penjual”), MH Century Property Holding Sdn Bhd (“Pembeli”) and Pin Hwa Properties Sdn Bhd (“Xxxx Punya”) bertarikh pada 05hb Jun, 2014 adalah dengan ini diisytiharkan bahawa Pihak Pemegang Serahhak dengan dibantu oleh Pelelong yang tersebut di bawah:- AKAN MENJUAL HARTANAH YANG DITERANGKAN DI BAWAH SECARA:- LELONGAN AWAM SECARA ATAS TALIAN PADA HARI SELASA, 10HB JANUARI, 2023, JAM 10.30 PAGI, XX XXXXX WEB xxx.xxxxxxxxxxxxxxxx.xxx Bakal pembida boleh mengemukakan bida untuk hartanah dalam talian melalui xxx.xxxxxxxxxxxxxxxx.xxx (Untuk pembidaan dalam talian, xxxx daftar sekurang-kurangnya satu (1) hari bekerja sebelum hari lelong untuk tujuan pendaftaran & pengesahan)

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