Plasma sampling Sample Clauses

Plasma sampling. 100 µL facial vein blood sampling before Tamoxifen induction and every 30 days will be processed to plasma for both treated and untreated mice. The PI will provide part of these samples to Minoryx to store or carry out the analysis of circulating MIN-102 amount and adiponectin. After euthanasia or sacrifice, a terminal plasma sample will be collected. Brain will be harvested and divided longitudinally: one half will be flash frozen in liquid nitrogen for molecular and biochemical investigations, the other half will be fixed in PFA 4%, cryopreserved in 30% sucrose and frozen in isopentane for histological evaluations. Experiment 2: in vivo evaluation of MIN-102 treatment in pre-symptomatic mice for histology/molecular biology Treatment: starting from the first day after Tamoxifen induction, 12 SLICK-Coasy (3 males and 3 females, treated and not treated), and 4 CTRL mice (2 males and 2 females, not treated) will be administered, when applicable, with a MIN-102 supplemented diet at a dose of 75 mg/kg/day. This regimen will be followed up as long as mice are in good clinical conditions as concerning weight gain, motor performance and overall health. All animals will be sacrificed at the same time point (2 mpi). After euthanasia or sacrifice, a terminal plasma sample will be collected. Brain will be harvested and divided longitudinally: one half will be flash frozen in liquid nitrogen for molecular and biochemical investigations, the other half will be fixed in PFA 4%, cryopreserved in 30% sucrose and frozen in isopentane for histological evaluations. Experiment 3: ex vivo evaluation of MIN-102 treatment efficacy Samples collected during Experiment 1 and 2 will be used to investigate the effect of MIN-102 on molecular, biochemical and histological signs related to the disease.
Sample 1
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Related to Plasma sampling

  • First sampling In the first sampling four lamps are selected at random. The first sample of two is marked A, the second sample of two is marked B.

  • Sampling The Licensee agrees that the Composition is purchased as a “Work Made for Hire” whereby the clearing of any sampled materials is the responsibility of Licensee.

  • Test Samples The Contractor is responsible for providing Samples of sufficient size for test purposes and for coordinating such tests with the Work Progress Schedule to avoid delay.

  • Testing Landlord shall have the right to conduct annual tests of the Premises to determine whether any contamination of the Premises or the Project has occurred as a result of Tenant’s use. Tenant shall be required to pay the cost of such annual test of the Premises; provided, however, that if Tenant conducts its own tests of the Premises using third party contractors and test procedures acceptable to Landlord which tests are certified to Landlord, Landlord shall accept such tests in lieu of the annual tests to be paid for by Tenant. In addition, at any time, and from time to time, prior to the expiration or earlier termination of the Term, Landlord shall have the right to conduct appropriate tests of the Premises and the Project to determine if contamination has occurred as a result of Tenant’s use of the Premises. In connection with such testing, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such non-proprietary information concerning the use of Hazardous Materials in or about the Premises by Tenant or any Tenant Party. If contamination has occurred for which Tenant is liable under this Section 30, Tenant shall pay all costs to conduct such tests. If no such contamination is found, Landlord shall pay the costs of such tests (which shall not constitute an Operating Expense). Landlord shall provide Tenant with a copy of all third party, non-confidential reports and tests of the Premises made by or on behalf of Landlord during the Term without representation or warranty and subject to a confidentiality agreement. Tenant shall, at its sole cost and expense, promptly and satisfactorily remediate any environmental conditions identified by such testing in accordance with all Environmental Requirements. Landlord’s receipt of or satisfaction with any environmental assessment in no way waives any rights which Landlord may have against Tenant.

  • Biological Samples If so specified in the Protocol, Institution and Principal Investigator may collect and provide to Sponsor or its designee Biological Samples (“Biological Samples”). 12.2.

  • Study An application for leave of absence for professional study must be supported by a written statement indicating what study or research is to be undertaken, or, if applicable, what subjects are to be studied and at what institutions.

  • RE-WEIGHING PRODUCT Deliveries are subject to re- weighing at the point of destination by the Authorized User. If shrinkage occurs which exceeds that normally allowable in the trade, the Authorized User shall have the option to require delivery of the difference in quantity or to reduce the payment accordingly. Such option shall be exercised in writing by the Authorized User.

  • Random Drug Testing All employees covered by this Agreement shall be subject to random drug testing in accordance with Appendix D.

  • SHOP DRAWINGS, PRODUCT DATA AND SAMPLES 4.12.1 Shop Drawings are drawings, diagrams, schedules and other, data specially prepared for the Work by the Contractor or any Subcontractor, manufacturer, supplier or distributor to illustrate some portion of the Work.

  • Samples Physical examples of materials, equipment, or workmanship that are representative of some portion of the Work and that establish the standards by which such portion of the Work will be judged. The Contractor shall furnish for approval all samples required by the Contract Documents. The Work shall be in accordance with approved samples.

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