Inhalation. Two concentrations of the test substance shall be used in this portion of the study, a low concentra- tion and a high concentration. The high concentration should ideally in- duce some overt toxicity, while the low concentration should correspond to a no observed level. Inhalation treat- ment should be conducted using a ‘‘nose-cone’’ or ‘‘head only’’ apparatus to prevent ingestion of the test sub- stance through ‘‘grooming’’.
Inhalation. Two concentrations of each test substance shall be used in this portion of the study, a low con- centration and a high concentration. The high concentration should induce minimal toxicity, but shall not exceed the lower explosive limit (LEL). The low concentration shall correspond to 1/10 of the high concentration. Inhala- tion treatment shall be conducted using a ‘‘nose-cone’’ or ‘‘head only’’ ap- paratus to reduce ingestion of the test substance through ‘‘grooming’’ or der- mal absorption.
Inhalation. T wo co n ce n t r a t io n s of t h e t es t s u bs t a n ce s h a ll be u sed i n t h i s po r t io n of t h e s t u d y , a low co n ce n t r a- t io n a n d a h ig h co n ce n t r a t io n . T h e h ig h co n ce n t r a t io n s h o u ld ide a ll y i n- d u ce so m e ove r t t oxici t y , w h ile t h e low co n ce n t r a t io n s h o u ld co rr espo n d t o a n o obse r ved level. I nh a l a t io n t r e a t - m e n t s h o u ld be co n d u c t ed u s i n g a ‘‘n ose- co n e’’ o r ‘‘h e a d o n l y’’ a pp a r a t u s t o p r eve n t i n ges t io n of t h e t es t s u b- s t a n ce t hr o u g h ‘‘g r oo m i n g’’.
Inhalation. May cause irritation to the respiratory tract. Symptoms may include coughing and shortness of breath. Ingestion: May cause irritation to the gastrointestinal tract, nausea, vomiting and abdominal pain. Symptoms may include headaches, blurred vision, fatigue, drowsiness and nervous system depression. CHRONIC: Repeated or prolonged exposure may cause skin rash and irritation of mucous membranes. Repeated ingestion may cause central nervous system deer ion, irritability and headache. Medical Conditions Aggravated by Exposure: Persons suffering from depression: alcoholism: neurological or psychological disorders may be more susceptible to the effects of the substance_ NFPA Rating: Health = 2: Flammability = 0: Instability = 0 11FPA Rating: Health = 2: Flammability = 0: Instability = 0 (Rating is for dry material, no information on blended solution).
Inhalation. May cause irritation to the respiratory tract. Symptoms may include coughing and shortness of breath. Ingestion: May cause irritation to the gastrointestinal tract, nausea, vomiting and abdominal pain. Symptoms may include headaches, blurred vision, fatigue, drowsiness and nervous system depression. CHRONIC: Repeated or prolonged exposure may cause skin rash and irritation of mucous membranes. Repeated ingestion may cause central nervous system deer ion, irritability and headache. Medical Conditions Aggravated by Exposure: Disclosure Schedules, page 15 US 1107409v.12 Persons suffering from depression, alcoholism, neurological or psychological disorders may be more susceptible to the effects of the substance. 11F PA Rating: Health = 2: Flammability = 0: Instability = 0 (Rating is for dry material, no information on blended solution). Disclosure Schedules, page 16 US 1107409v.12
Inhalation. This product does not produce any harmful fumes. --------------------------------------------------------------------------------------------------------------------- FIRE HAZARDS: NON-FLAMMABLE This product is an aqueous solution, and is therefore non-flammable. It may evolve hazardous fumes under fire conditions. --------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------- DATE JULY 2005 VERSION NO. 3 --------------------------------------------------------------------------------------------------------------------- EXHIBIT B PRODUCT ATTACHMENT PRODUCT: SOLTAMOX(R) (TAMOXIFEN CITRATE) -------------------------------------------------------------------------------- [**] [**] [**] -------------------------------------------------------------------------------- [**] [**] [**] -------------------------------------------------------------------------------- Agreed upon this day of June, 2006: ------ ONCOLOGY THERAPEUTICS CYTOGEN CORPORATION NETWORK, J.V.L.P. By: /s/ Xxxxx Xxxxx By: /s/ Xxxxxxx X. Xxxxxx --------------- --------------------- Name: Xxxxx Xxxxx Name: Xxxxxxx X. Xxxxxx Title: Vice- President, Operations Title: Senior Vice President and General Counsel EXHIBIT C FEE SCHEDULE [**]
Inhalation i. Immediately remove the victim to clean air. Call 911, inform the emergency dispatcher of a hydrofluoric acid exposure and request emergency transport.
Inhalation a. Silicosis Respirable crystalline silica (quartz) can cause silicosis, a fibrosis (scarring) of the lungs. Silicosis may be progressive; it may lead to disability and death.
Inhalation. Personnel affected by methacrylic acid vapors must be moved at once to an uncontaminated atmosphere. another trained emergency health professional as soon as possible and transport to a suitable clinic or hospital. If breathing is difficult, trained personnel should administer oxygen.
Inhalation. May cause irritation to the respiratory tract. Symptoms may include coughing and shortness of breath. Ingestion: May cause irritation to the gastrointestinal tract, nausea, vomiting and abdominal pain. Symptoms may include headaches, blurred vision, fatigue, drowsiness and nervous system depression. CHRONIC: Repeated or prolonged exposure may cause skin rash and irritation of mucous membranes. Repeated ingestion may cause central nervous system deer ion, irritability and headache. Medical Conditions Aggravated by Exposure: Persons suffering from depression, alcoholism, neurological or psychological disorders may be more susceptible to the effects of the substance. 11F PA Rating: Health = 2: Flammability = 0: Instability = 0 (Rating is for dry material, no information on blended solution).
