Secondary Screening definition

Secondary Screening means conducting any assay, screen or other test on a Collaboration Compound after the Primary Screening of such Collaboration Compound, for the purpose of confirming the results of the Primary Screening or determining additional physical chemical, pharmaceutical and process profiles and in vivo pharmacological and toxicological profiles.

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Secondary Screening means conducting any assay, screen or other test run after the High Throughput Screening on Aventis Compounds or Nicotinic Compounds or Chemical Optimization of Aventis Compounds or Nicotinic Compounds.

Secondary Screening means conducting any assay, screen or other test using intracellular receptors on a Collaboration Compound, after the Primary Screening of such Collaboration Compound, for the purpose of confirming the results of the Primary Screening or to test such Collaboration Compound for cross-reactivity with other than the Designated Target.

Examples of Secondary Screening in a sentence

• Targacept and APSA shall conduct Primary Screening and Secondary Screening of Collaboration Compounds during the Research Term, as set forth in the Research and Development Plan and the Semi-Annual Research Plans, and shall inform the ERC of the progress and results thereof.

• The ERC shall meet at the earliest reasonably practicable time to establish, by mutual agreement of the Parties, the priority for performing the Primary Screening and Secondary Screening of the Collaboration Compounds and to amend the initial Semi-Annual Research Plan as required to reflect such agreement.

• The ERC shall review the results of the Primary Screening and Secondary Screening of the Collaboration Compounds provided by the Parties pursuant to Section 2.2(a).

• Dynavax shall be responsible (at the expense of AstraZeneca), through either internal production capabilities or Third Party manufacturers approved by the JSC, for the manufacture [ * ] of preclinical Dynavax ISS or Collaboration ISS for use in the Joint Research Programme through the Primary Screening Phase and Secondary Screening Phase for any such Dynavax ISS or Collaboration ISS.

• During the Research Term, Targacept and Aventis shall conduct High Throughput Screening of Aventis Compounds and Secondary Screening of Aventis Compounds and Nicotinic Compounds, as set forth in the Research and Development Plan and the Semi-Annual Research Plans, and shall inform the ARC of the progress and results thereof.

• The ARC shall meet at the earliest reasonably practicable time to establish, by mutual agreement of the Parties, the priority for performing the High Throughput Screening and Secondary Screening of the Aventis Compounds and Secondary Screening of the Nicotinic Compounds and to amend the initial Semi-Annual Research Plan as required to reflect such agreement.

• Within [*] after the Effective Date, the Parties will develop a Work Plan to achieve a Start Development Checkpoint for a Secondary Screening System within [*] after the Effective Date; except that, if the Work Plan requires four (4) or more persons beyond those persons already committed to any Work Plans then in place, then the Work Plan will achieve a Start Development Checkpoint for a Secondary Screening System within [*] after the Effective Date.

• Hits (Fragments, Mixtures (if applicable) or Ligers that are positive in both assays) will be further evaluated in Secondary Screening Assays according to the following scheme: Algorithm A [**] Algorithm B [**] Algorithm A is preferred over Algorithm B, however if [**] will have insufficient throughput, Algorithm B will be selected, if the alternative primary assays are available.

• Following the Research Term and for the period of exclusivity between the Parties according to Sections 2.8.1 and 2.15, Ligand will, if requested by BMS and so long as BMS is using Diligent Efforts to discover or develop Collaboration Compounds, perform such Secondary Screening of Collaboration Compounds against *** *** and to use Diligent Efforts to perform same within a reasonable period of such request from BMS.

• Ligand's commitment for providing Secondary Screening under this provision shall not exceed *** .

More Definitions of Secondary Screening

Secondary Screening means conducting any assay, screen or other test using intracellular receptors on a Collaboration Compound for the purpose of confirming the results of the Primary Screening or to test such Collaboration Compound for cross-reactivity with other than the Designated Target.

Secondary Screening means the (i) retest of compounds identified as active in Primary Screening and/or (ii) the screening of compounds identified as active in Primary Screening against a closely related Hyseq Target to determine selectivity.

Secondary Screening means conducting any cell based or other assay, screen or other test on a RESEARCH COMPOUND using in vitro cell systems

Secondary Screening means conducting any cell based or other assay, screen or other test on a RESEARCH COMPOUND using in vitro cell systems or reagents after the PRIMARY SCREENING of such RESEARCH COMPOUND for the purpose of confirming the results of the PRIMARY SCREENING or to test the RESEARCH COMPOUND for cross-reactivity with other than the DESIGNATED PATHWAYS or for determining other relevant properties of the RESEARCH COMPOUND.