LRRK2 definition

LRRK2 means a naturally occurring Leucine-rich repeat kinase 2 mRNA sequence or protein, [***].
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LRRK2 means a naturally occurring Leucine-rich repeat kinase 2 protein, including human and non-human versions thereof and wild-type and mutants (variants) thereof, as well as domain truncations thereof; full-length or domain truncated LRRK2 in the presence of ligands; full-length or domain truncated LRRK2 having additional tags and tag locations; and full-length or domain truncated LRRK2 reconstituted under different solubilization conditions. For clarity, LRRK2 mutants include, [***].
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Examples of LRRK2 in a sentence

  • Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.

  • This would include, for example, the more common LRRK2 and GBA mutations, in addition to previously validated risk variants in SNCA and MAPT.

  • There is one predominant disease-producing mutation in LRRK2, G2019S which has been found at significantly greater frequencies among PD patients of Ashkenazi Jewish and northern African ancestry.

  • Sen, S., Webber, P.J. and West, A.B. (2009) Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.

  • LRRK2 G2019S as a cause of Parkinson’s disease in Ashkenazi Jews.

  • However, it has been shown that not all individuals who inherit a LRRK2 mutation will develop PD.

  • Mutations in LRRK2 result in autosomal dominant PD that presents at approximately 60 years of age, but which can also occur more than a decade earlier or later.

  • Phosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases.

  • Individuals who carry a mutation in one of the 2 LRRK2 alleles are at significantly greater risk of developing PD.

  • Gomez, R.C., Wawro, P., Lis, P., Alessi, D.R. and Pfeffer, S.R. (2019) Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases.

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