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Publication No. Patent No. [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] [****] EXHIBIT C Development Plan [****] EXHIBIT D Third Party Licenses [****] EXHIBIT E
Publication No. Title Filing Date Patent No. Issue Date Expiration Date Status China CN 124418-32078 PAZ-320-1 CNDV DIV 201510265009.X 104844472B SALTS AND POLYMORPHS OF A TETRACYCLINE COMPOUND 05/26/2009 ZL201510265009.X 02/13/2018 05/26/2029 Granted Macau MO 124418-32122 PAZ-320-1 MODV DIV J/003079 SALTS AND POLYMORPHS OF A TETRACYCLINE COMPOUND 05/26/2009 J/003079 08/07/2018 05/26/2029 Granted Hong Kong HK 124418-32039 PAZ-320-1-HK EP 11109171.9 1154757 SALTS AND POLYMORPHS OF A TETRACYCLINE COMPOUND 05/26/2009 HK1154757 12/18/2015 05/26/2029 Granted Hong Kong HK 124418-32038 PAZ-320-1HKDV DIV 15105134.9 1204526A SALTS AND POLYMORPHS OF A TETRACYCLINE COMPOUND 05/26/2009 Pending Taiwan TW 124418-32063 PAZ-320-1-TW ORD 098117308 SALTS AND POLYMORPHS OF A TETRACYCLINE COMPOUND 05/25/2009 I585071 06/01/2017 05/25/2029 Granted Taiwan TW 124418-32088 PAZ-320-1 TWDV DIV 106103523 201741281 SALTS AND POLYMORPHS OF A TETRACYCLINE COMPOUND 05/25/2009 I680117 12/21/2019 05/25/2029 Granted Taiwan TW 124418-32018 PAZ-320-1 TWDV2 DIV 108126026 SALTS AND POLYMORPHS OF A TETRACYCLINE COMPOUND 05/25/2009 Pending China CN 124418-51128 PAZ-511CN PCT 201780032098.0 109152789 METHODS FOR TREATING AND PREVENTING C. DIFFICILE INFECTION 03/24/2017 Pending ACTIVE/105323943.11
Publication No. Patent No. Country Application No. Publication No. Patent No. Country Application No. Publication No. Patent No. Country Application No. Publication No. Patent No. Country Application No. Publication No. Patent No. EXHIBIT C Development Plan [****] EXHIBIT D Third Party Licenses [****] EXHIBIT E
Publication No. Patent No. [***] [***] [***] [***] Exhibit B MacroGenics Licensed Trademarks [***] Exhibit C Global Development Plan and Territory Specific Development Plan [***] Exhibit D SAFETY MANAGEMENT PLAN COMPONENTS [***] Exhibit E Product Royalty Rates Applicable Product Aggregate Net Sales threshold of the applicable Products in the Territory: Then the Product Royalty Rate Percentage shall be (%): Margetuximab Products On that portion of aggregate Net Sales in a Calendar Year less than [***] [***] On the portion of Net Sales in a Calendar Year equal to or greater than [***] but less than [***] [***] On that portion of Net Sales in a Calendar Year greater than [***] 20 MGD013 Products All [***] [***] Trident Products All [***] [***]
Publication No. Title Filing Date Patent No. Issue Date Expiration Date Status Hong Kong HK 124418-51739 PAZ-517HK PCT 62020003975.3 40014127 9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND USE THEREOF IN TREATING COMMUNITY-ACQUIRED BACTERIAL PNEUMONIA (CABP) 10/31/2017 Pending Taiwan TW 124418-51763 PAZ-517TW ORD 106137764 201821082 9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND USE THEREOF IN TREATING COMMUNITY-ACQUIRED BACTERIAL PNEUMONIA (CABP) 11/01/2017 Pending ACTIVE/105323943.11 Trademarks in the Territory Trademark Country App. No. NUZYRA CN 31636176 (Class 5) CN 35827956 (Class 35) HK 304951639 (Class 5) MO N/155342 (Class 5) TW 107063000 (Class 5) (Class 5) CN 31636177 CN 38800002 (Class 35) CN 38783109 (Class 44) CN 31636177A (Class 5 & 44) TW 107038311 NUZYRA CENTRAL CN 37002978 (Class 5) 37002977 (Class 16) 37002976 (Class 36) 37002975 (Class 39) 37002974 (Class 44) 238584769 v5
Publication No. 2132571 Patent Cooperation Treaty Sensitive Immunochromatographic Assay Application Date: April 10, 2003 Publication Date: October 23, 2003 Application No.: PCT/CA03/00539 Publication No.: WO03/087822 Modular Assay Reader System And Apparatus Application Date: March 19, 2008 Publication Date: October 9, 2008 Application No.: PCT/US2008/003609 Publication No.: WO2008/121239 Heated Assays For Influenza Application Date: January 6, 2009 Publication Date: July 23, 2009 Application No.: PCT/US2009/000035 Publication No.: WO2009/091501 Australia Multiple Analyte Immunoassay Application Date: December 11, 2007 Application No.: 2007332776 Canada Multiple Analyte Immunoassay Application Date: December 11, 2007 Application No.: 2671578 Comparative Multiple Analyte Assay Application Date: February 15, 2008 Application No.: 2677977 China (People's Republic) Sensitive Immunochromatographic Assay Application Date: April 10, 2003 Publication Date: July 27, 2005 Application No.: 3808096.6 Publication No.: CN1646913 Multiple Analyte Immunoassay Application Date: December 11, 2007 Application No.: 200780049910.7 India Multiple Analyte Immunoassay Application Date: December 11, 2007 Application No.: 3613DELNP2009 Hong Kong Sensitive Immunochromatographic Assay Application Date: January 3, 2006 Publication Date: April 21, 2006 Application No.: 61000235 Publication No.: 1080142A Mexico Multiple Analyte Immunoassay Application Date: December 11, 2007 Application No.: MXA2009006205 United States of America Immunoassay Employing Two-Step Internal Calibration Reaction Application Date: December 21, 2009 Publication Date: May 27, 2010 Application No.: 12/643,039 Publication No.: 20100129936 Multiple Analyte Immunoassay Application Date: June 4, 2009 Publication Date: February 25, 2010 Application No.: 12/478,305 Publication No.: 20100047857 Heated Assays For Influenza Application Date: July 12, 2010 Application No.: 12/834,116 TRADEMARKS Mark Registration Date Registration No. United States of America R LOGO August 6, 2002 2605067 RAMP EXPANDED October 8, 2002 2632327 RAMP RESPONSE BIOMEDICAL & DESIGN October 21, 2008 3521400 Canada R LOGO September 3, 2002 566825 RAMP September 3, 2002 566826 RAMP RESPONSE BIOMEDICAL & DESIGN February 24, 2010 TMA760,109 European Community R LOGO August 19, 1998 913947 RAMP February 20, 1997 474247 RAMP RESPONSE BIOMEDICAL & DESIGN July 24, 2008 6133797 Japan RAMP December 28, 2007 5101824 RAMP RESPONSE BIOMEDICAL & DESIGN November 22, 2007 509406...
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Publication No. Title Filing Date Patent No. Issue Date Expiration Date Status Hong Kong HK 124418-51139 PAZ-511HK PCT 19127080.0 40003650A METHODS FOR TREATING AND PREVENTING C. DIFFICILE INFECTION 03/24/2017 Pending China CN 124418-51528 PAZ-515CN PCT 201780058535.6 109789153 9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND USES THEREOF 08/03/2017 Pending Hong Kong HK 124418-51539 PAZ-515HK PCT 19133244.4 40009772 A 9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND USES THEREOF 08/03/2017 Pending Taiwan TW 124418-51563 PAZ-515TW ORD 106126049 9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND USES THEREOF 08/02/2017 Pending China CN 124418-51728 PAZ-517CN PCT 201780079110.3 110087655 9-AMINOMETHYL MINOCYCLINE COMPOUNDS AND USE THEREOF IN TREATING COMMUNITY-ACQUIRED BACTERIAL PNEUMONIA (CABP) 10/31/2017 Pending ACTIVE/105323943.11