Melatonin Efficacy in Treating Metabolic Syndrome Sample Clauses

Melatonin Efficacy in Treating Metabolic Syndrome. The effects of melatonin on improving signs and symptoms of metabolic syndrome, as well as the overall syndrome itself, have been shown in various animal studies. (Xxxxxxxxx, Xxxxx, & Xxxxxxxxx, 2003; Xxxxx, et al., 2000). Both animal and human studies have documented melatonin’s hypotensive effect, antioxidative potential, and improvement in lipid profile and reduction of pharmaceutical agent toxicity. (Xxxxxxx, et al., 2011; Xxxxxx, Xxx, Xxxxx, & Xxxx, 2002). Xxxxxxx et al. conducted a study in 2011 to assess melatonin efficacy in treating metabolic syndrome and found that melatonin significantly reduced the patients’ BMI, systolic and diastolic blood pressure (SBP, DBP) and thiobarbituric acid reactive substrates after one-month and two-month administration. They also reported that melatonin significantly lowered SBP comparing the two visits at the end of the first and second month and further proposed that prolonged administration of melatonin may yield a better outcome. (Xxxxxxx, et al., 2011). An eight-week, double-blind, randomized, placebo-controlled, parallel-group clinical trial done in 2014 examined the metabolic effects of melatonin among second-generation antipsychotics (SGA) patients, a group of people who tend to have metabolic disturbances. The results supported the therapeutic role of melatonin in preventing patients from experiencing SGA metabolic effects. (Xxxx-Xxxx, et al., 2014). In a review paper by Xxxxxxxxxxxx, du Toit, and Xxxxxxx et al, the dosage level of melatonin was proposed to be a particular challenge since both low and high doses seemed to be effective in experimental animals. The authors suggested that the therapeutic characteristics of melatonin need further investigation considering its potential benefits on preventing or reversing harmful effects of obesity and related metabolic disorder. (Nduhirabandi, du Toit, & Xxxxxxx, 2012). In addition, Xxxxxxxxxx et al. recommended more studies to further prove the efficacy of melatonin with dosage level increases as well as longer duration of melatonin treatment. (Xxxxxxxxxx, et al., 2013).
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