Erythrocyte phospholipids Sample Clauses

Erythrocyte phospholipids. Erythrocyte phospholipids are characterized by a large amount of 16:0 (21.2-34.9%), which is twice as abundant as any other fatty acid. The proportions of 18:0, 18:1n-9 and 20:4n-6 were around 14%. 18:2n-6 has a lower quantity (11.2%). With reference to plasma PL fatty acid composition, the profusion of very LC n-3 PUFA is equivalent to that of plasma PL. However, the abundances of 18:2n-6 and 20:4n-6 are half and double that of plasma PL respectively. This lower amount of 18:2n-6 in erythrocyte PL is a typical feature of cell membrane and indicates a tight metabolic regulation of the composition of this fatty acid (Xxxxxx et al. 2008). Erythrocyte lipids have been widely used to assess the balance between n-6 and n-3 fatty acids in the diet but are relatively insensitive to changes in SFA intake. Erythrocyte phospholipids are considered a longer-term indicator of past intake. Although erythrocytes have a life span of about 120 days, it is possible to bring about changes in their composition within a few days and while changes in the proportion of LC n-3 PUFA persist for longer following withdrawal of supplementation, values for EPA still changed over a 5-week period (Xxxxxxx et al.1981).
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