ADIPOQ polymorphisms Sample Clauses

ADIPOQ polymorphisms. The ADIPOQ gene is very polymorphic; several single nucleotide polymorphisms (SNPs) have been detected. From the known polymorphisms in the National Centre for Biotechnology Information (NCBI) and in the literature, 53 SNPs of ADIPOQ have been identified (Xxxx et al, 2006). Some of these polymorphisms have been associated with the expression of adiponectin, suggesting their determination of circulating concentrations (Xxxx & Xxxxxx, 2006). Associations were found between +276 G- allele and lower adiponectin concentrations in the Spanish population, healthy Caucasians, nondiabetic Koreans and obese Japanese subjects (Xxxxxxxx-Xxxxxxx et al, 2005; Xxxxxxxxx et al 2006; Xxxx et al, 2005; Xxxx et al, 2002). An association was also reported in healthy young Finnish subjects where the +276 T-allele was associated with elevated adiponectin concentrations (Mousavinasab et al, 2006). Woo et al. (2006) showed a significant association between SNP alleles -11391A, +267T and -10066G with higher adiponectin concentrations in White Americans. A similar association with -11391 A and +267 T-alleles was found in African Americans. They also showed that three SNP haplotypes +45, +276 and +349 T/T/A and T/G/G were significantly associated with higher adiponectin in White American, but not Africans. In the same study the strongest association with serum adiponectin was found with haplotypes from the promoter through to the second intron SNPs -11391 to +349 in White Americans and SNPs -11391 to + 45 in African Americans (Woo et al, 2006). In a more recent study, SNP association with adiponectin was tested in two independent populations of Caucasian females. In the Chingford cohort (n = 808), the common allele of -10066 G/A and the rare alleles of 11391 G/A, -7734 C/A, +276 G/T and +3228 C/T were significantly associated with higher adiponectin concentrations. In the Twins UK cohort (n = 2718), the same association was found with all SNPs except for +3228 C/T (Xxxxxxxx et al, 2008). In the CARDIA study, -10066 G/A, -11391 G/A and +276 G/T were strongly associated with serum adiponectin concentrations in White subjects, with dose – response relationship of mean adiponectin concentrations across genotypes. This study also reported that only -11391 G/A was significantly associated with serum adiponectin in African Americans (Xxxxxx et al, 2010) similar association was reported by (Xxxx et al 2006; Xxxxxxx et al, 2002). Association between ADIPOQ gene variants with metabolic syndro...
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