PPARG gene Sample Clauses

PPARG gene. The human PPARG gene is located on chromosome 3 at position 3p25 (Xxxxxx- Xxxxxxxx& Xxxxx, 2006). The PPARG gene includes 9 exons and exceeds 100 kb in length. It measures 146,483 base pairs in length, translating into 476 amino acids. Four different subtypes of PPARγ mRNA (-γ1,-γ2,-γ3 and -γ4) transcribed from four different promoters have been identified, which give rise to two different PPARγ proteins (Xxxxxxxxx et al, 2008) as shown in Figure 1.7. The transcription from promoter – γ1, - γ3 and- γ4 mRNA results in a PPAR- γ1 protein of 477 amino acids. The PPAR- γ2 protein of 505 amino acids is produced by transcription from promoter γ2 (Xxxxxxxxx et al, 2008), exclusively expressed in adipose tissue (Xxxxxx & Xxxxx, 2005).
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