Dosing Regimen definition
Dosing Regimen. Phase A: Three inductions/week to test animals on single test site (nine total inductions) Phase B: Test animals challenged on new test site and challenge control animals dosed approximately 2 weeks after Induction 9 Phase C: Test animals rechallenged on a test site with naive rechallenge control animals dosed (if needed).
Dosing Regimen. A single daily dose for 14-days followed by a 7-Day recovery period. Route of Administration: Transdermal patch or subcutaneous dose administration. Spares: 4 animals Total Population: 30 animals Age: Approximately 2.5 – 3.5 kg at receipt Source: ▇▇▇▇▇▇▇ River Pretreatment Period: Approximately 10 days.
Dosing Regimen. Phase A: Three inductions/week to test animals on single test site (nine total inductions) Phase B: Test animals challenged on new test site and challenge control animals dosed approximately 2 weeks after Induction 9 Phase C: Test animals rechallenged on a test site with naive rechallenge control animals dosed (if needed). Route of Administration: Dermal (skin painting) dose administration — 6 hour exposure Test System: Group Number of Animals Test/Placebo 10/10 Challenge Control 10 Rechallenge 10 DNCB Positive Control Test 10 Positive Control 10 Spares 5 animals Total Population 69 animals Age Approximately 7 weeks at receipt Source ▇▇▇▇▇▇▇ River Laboratories Pretreatment Period At least 5 days Mortality/Cageside Observations: Mortality/viability observations will be conducted on twice daily on all animals. Positive clinical observations only. Dermal scoring at 24 and 48 hours. Body Weight/Food Consumption: Body weights obtained at 3 intervals. Terminal Procedures: Animals terminated without necropsy Reporting: Audited draft report provided in approximately 4 weeks. Archiving: Archiving materials will be maintained through final report issuance. Date Created: October 2, 2009 Sponsor: Radius Title: A 14-Day Local Tolerance Study in Rabbits with a 7-Day Recovery Period Study Number: SSU00067 ▇▇▇▇▇▇▇ River Facility: Ohio Compliance: GLP Species/Strain: New Zealand White Rabbits Dose Formulation Preparation (assumes basic dose preparation): Test material to be dispensed as received; no samples obtained. Dose Formulation Analysis (assumes standard HPLC-UV method): N/A Dosing Regimen: A single daily dose for 14-days followed by a 7-Day recovery period. Route of Administration: Transdermal patch or subcutaneous dose administration. Test System: Number of Animals Group: Dose Males Females 1 Patch - Control 3 (2) 3 (2)
Examples of Dosing Regimen in a sentence
Dose Formulation Analysis (assumes standard HPLC-UV method): N/A Dosing Regimen: Once daily for 182 days (6 months).
Dose Formulation Analysis (assumes standard HPLC-UV method: N/A Dosing Regimen: Once daily for 7 days.
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