Common use of Pass-Through Costs Clause in Contracts

Pass-Through Costs. Pass-through costs are in US dollars and include, but are not limited to, those expenses listed below. Manager will invoice Sponsor for actual costs in these areas. Actual costs will be kept to reasonable levels through adherence to inVentiv Health Clinical’s travel policy and prudent negotiation with outside providers. Pass-through costs are presented in the table below: Task Original (USD) New NA (USD) Assumption Changes influencing the change in the budget Additional comments Site Visit Travel [****] [****] Original contract has a total of [****] site visits. [****] Investigators' Meeting Organisation [****] [****] WebEx costs included in original budget. Investigator meetings have been changed to F2F. Kick-off Meeting Travel/Attendance [****] [****] Originally assumed [****] cover study globally, as studies and timelines were the same. Now assume [****] for each study, since timelines are vastly different and study teams not identical. Shipping/Photocopying [****] [****] Original contract assumes [****]. New NA budget assumes [****]. Translation [****] [****] Original contract [****]. New NA budget [****]; Costs for translating patient recruitment materials have been removed as this service is not included in updated budgets. Regulatory Fees [****] [****] assumed [****]. Current costing tool separates out Task Original (USD) New NA (USD) Assumption Changes influencing the change in the budget Additional comments [****] (& Regulatory) Fees [****] [****] New NA costing assumes [****]. Regulatory Fees and [****] fees, as seen in EU costing. For original costing and new NA costing, these fees remain combined. EDC Studies/3G Cards [****] [****] [****] [****] [****] [****] [****] EDC Fees ([****]) [****] [****] EDC Fees were included in Professional Fees in initial bid Pass Through Costs [****] [****]

Pass-Through Costs. Pass-through costs are in US dollars and include, but are not limited to, include those expenses listed below. Manager inVentiv Health Clinical will invoice Sponsor Client for actual costs in these areas, it being understood that any pass-through costs in excess of the amounts set out below will require the Client’s prior written approval. Actual inVentiv Health Clinical will use its best efforts to keep actual costs will be kept to reasonable levels through adherence to inVentiv Health Clinical’s travel policy and prudent negotiation with outside providers. Pass-through costs are presented in the table below: Task Original Current (USD) New NA (USD) Change Order #5.1 Assumption Changes influencing the change in the budget Additional comments Site Visit Travel $[****] $[****] Original contract has a total of No change Investigators' Meeting Organisation $[****] site visits. $[****] Investigators' Meeting Organisation [****] [****] WebEx costs included in original budget. Investigator meetings have been changed to F2F. No change Kick-off Meeting Travel/Attendance $[****] $[****] Originally assumed No change Shipping/Photocopying $[****] cover study globally, as studies and timelines were the same. Now assume $[****] for each study, since timelines are vastly different and study teams not identical. Shipping/Photocopying No change Translation $[****] $[****] Original contract assumes No change Regulatory Fees $[****] $[****] No change Ethics Committee Fees $[****] $[****] No change EDC Studies/3G Cards $[****] $[****] No change DSMB member fees $[****] $[****] No change EDC Fees (Oracle) $[****] $[****] Oracle has quoted $[****]. New NA budget assumes to implement and execute the Quest Data integration to Inform DB and the Oracle Contract is being extended by [****] months for a cost of $[****] CRA Face to Face Meeting Travel expenses $[****] $[****] No change Pass Through Costs $[****] $[****]. Translation [****] [****] Original contract [****]. New NA budget [****]; Costs for translating patient recruitment materials have been removed as this service is not included in updated budgets. Regulatory Fees [****] [****] assumed [****]. Current costing tool separates out Task Original (USD) New NA (USD) Assumption Changes influencing the change in the budget Additional comments [****] (& Regulatory) Fees [****] [****] New NA costing assumes [****]. Regulatory Fees and [****] fees, as seen in EU costing. For original costing and new NA costing, these fees remain combined. EDC Studies/3G Cards [****] [****] [****] [****] [****] [****] [****] EDC Fees ([****]) [****] [****] EDC Fees were included in Professional Fees in initial bid Pass Through Costs [****] [****]

Pass-Through Costs. Pass-through costs are in US dollars and include, but are not limited to, include those expenses listed below. Manager inVentiv Health Clinical will invoice Sponsor Client for actual costs in these areas, it being understood that any pass-through costs in excess of the amounts set out below will require the Client’s prior written approval. Actual inVentiv Health Clinical will use its best efforts to keep actual costs will be kept to reasonable levels through adherence to inVentiv Health Clinical’s travel policy and prudent negotiation with outside providers. Pass-through costs are presented in the table below: Task Original Current (USD) New NA (USD) Start Up Work in [****] and [****] Assumption Changes influencing the change in the budget Additional comments Site Visit Travel [****] [****] Original contract has a total of [****] site visits. [****] Investigators' Meeting Organisation [****] [****] WebEx costs included in original budgetNo change. Investigator meetings have been changed to F2F. Kick-off Meeting Travel/Attendance [****] [****] Originally assumed [****] cover study globally, as studies and timelines were the same. Now assume [****] for each study, since timelines are vastly different and study teams not identicalNo change. Shipping/Photocopying [****] [****] Original contract assumes [****]. New NA budget assumes [****]. No change Translation [****] [****] Original contract No change Task Current (USD) Start Up Work in [****]. New NA budget ] and [****]; Costs for translating patient recruitment materials have been removed as this service is not included ] Assumption Changes influencing the change in updated budgets. the budget Additional comments Regulatory Fees [****] [****] assumed [****]. Current costing tool separates out Task Original (USD) New NA (USD) Assumption Changes influencing the No change in the budget Additional comments [****] (& Regulatory) Ethics Committee Fees [****] [****] New NA costing assumes [****]. Regulatory Fees and [****] fees, as seen in EU costing. For original costing and new NA costing, these fees remain combined. No change EDC Studies/3G Cards [****] [****] No change DSMB member fees [****] [****] [****] [****] [****] No change EDC Fees ([****]Oracle) [****] [****] EDC Fees were included in Professional Fees in initial bid No Change CRA Face to Face Meeting Travel expenses [****] [****] No change Pass Through Costs [****] [****]

Pass-Through Costs. Pass-through costs are in US dollars and include, but are not limited to, include those expenses listed below. Manager inVentiv Health Clinical will invoice Sponsor Client for actual costs in these areas, it being understood that any pass-through costs in excess of the amounts set out below will require the Client’s prior written approval. Actual inVentiv Health Clinical will use its best efforts to keep actual costs will be kept to reasonable levels through adherence to inVentiv Health Clinical’s travel policy and prudent negotiation with outside providers. Pass-through costs are presented in the table below: Task Original Current (USD) New NA (USD) Additional sites & protocol amendments Assumption Changes influencing the change in the budget Additional comments Site Visit Travel [****] [****] Original contract has a total of [****] site visits. [****] Investigators' Meeting Organisation [****] [****] WebEx costs included in original budget. Investigator meetings have been changed to F2F. [****] Kick-off Meeting Travel/Attendance [****] [****] Originally assumed [****] cover study globally, as studies and timelines were the same. Now assume [****] for each study, since timelines are vastly different and study teams not identical. Shipping/Photocopying [****] [****] Original contract assumes [****]. New NA budget assumes [****]. ] Translation [****] [****] Original contract [****]. New NA budget [****]; Costs for translating patient recruitment materials have been removed as this service is not included in updated budgets. ] Regulatory Fees [****] [****] assumed [****]. Current costing tool separates out Task Original (USD) New NA (USD) Assumption Changes influencing the change in the budget Additional comments [****] (& Regulatory) [****] Ethics Committee Fees [****] [****] New NA costing assumes [****]. Regulatory Fees and [****] fees, as seen in EU costing. For original costing and new NA costing, these fees remain combined. EDC Studies/3G Cards [****] [****] [****] DSMB member fees [****] [****] [****] [****] EDC Fees ([****]Oracle) [****] [****] EDC Fees were included in Professional Fees in initial bid [****] [****] CRA Face to Face Meeting Travel expenses [****] [****] [****] Pass Through Costs [****] [****]