Revised Costs Clause Samples

Revised Costs. If the Plans are revised pursuant to Paragraph 2(b), Landlord shall request that the contractors provide revised cost estimates based upon the revisions to the Plans. Such notifications and revisions shall be in accordance with the standards set forth in Paragraph 1 of this Work Letter. Within five (5) days after receipt of the contractor's original written cost estimate and the description, if any, of Tenant Delay, Tenant shall give its final approval of the Plans to Landlord which shall constitute authorization to commence the construction of the Tenant Improvements in accordance with the Plans, as modified or revised. Tenant shall signify its final approval by signing a copy of each sheet or page of the Plans and delivering such signed copy to Landlord.

Revised Costs. Costs for this study are presented below in two categories, pass-through costs and professional fees. 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd. 07 November 2016 1.1.1 Pass-Through Costs Pass-through costs are in US dollars and include those expenses listed below. inVentiv Health Clinical will invoice Client for actual costs in these areas, it being understood that any pass-through costs in excess of the amounts set out below will require the Client’s prior written approval. inVentiv Health Clinical will use its best efforts to keep actual costs to reasonable levels through adherence to inVentiv Health Clinical’s travel policy and prudent negotiation with outside providers. Pass-through costs are presented in the table below: Site Visit Travel $[****] [****] $[****] [****] No change Investigators' Meeting Organization $[****] $[****] No change Kick-off Meeting Travel/Attendance $[****] $[****] No change Shipping/Photocopying $[****] $[****] No change Translation $[****] $[****] No change Regulatory Fees $[****] $[****] No change Ethics Committee Fees $[****] $[****] No change EDC Studies/3G Cards $[****] $[****] No change DSMB member fees $[****] $[****] Increased DSMB member hourly rate to $[****] from $[****] EDC Fees (Oracle) $[****] $[****] No change CRA Face to Face Meeting Travel expenses $[****] $[****] No change Pass Through Costs $[****] $[****] 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd. 07 November 2016 5 1.1.2 Investigator Grants Costs $[****] $[****] No Change Estimate only. Will be paid based on actual costs as approved by the Client. 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd.

Revised Costs. Costs for this study are presented below in two categories, pass-through costs and professional fees. 1.1.1 Pass-Through Costs Pass-through costs are in US dollars and include, but are not limited to, those expenses listed below. Manager will invoice Sponsor for actual costs in these areas. Actual costs will be kept to reasonable levels through adherence to inVentiv Health Clinical’s travel policy and prudent negotiation with outside providers. Pass-through costs are presented in the table below: Site Visit Travel [****] [****] Original contract has a total of [****] site visits. [****] Investigators' Meeting Organisation [****] [****] WebEx costs included in original budget. Investigator meetings have been changed to F2F. Kick-off Meeting Travel/Attendance [****] [****] Originally assumed [****] cover study globally, as studies and timelines were the same. Now assume [****] for each study, since timelines are vastly different and study teams not identical. Shipping/Photocopying [****] [****] Original contract assumes [****]. New NA budget assumes [****]. Translation [****] [****] Original contract [****]. New NA budget [****]; Costs for translating patient recruitment materials have been removed as this service is not included in updated budgets. Regulatory Fees [****] [****] assumed [****]. Current costing tool separates out Regulatory Fees and [****] fees, as seen in EU costing. [****] (& Regulatory) Fees [****] [****] New NA costing assumes [****]. For original costing and new NA costing, these fees remain combined. EDC Studies/3G Cards [****] [****] [****] [****] [****] [****] [****] EDC Fees ([****]) [****] [****] EDC Fees were included in Professional Fees in initial bid Pass Through Costs [****] [****] 1.1.2 Investigator Grants Costs [****] [****] Original contract assumed [****] patients. New NA costing assumed [****] patients Estimate only. Will be paid based on actual costs as approved by the Client.