Functions of SR proteins Sample Clauses

Functions of SR proteins. SR proteins have multiple roles in RNA processing including constitutive and alternative splicing (Xxxxxxxxx, 2005; Xxxxxx et al., 1992). They mediate their function either by binding directly to pre-mRNA or indirectly to components in the spliceosome during splicing to enhancer or repress nearby splice sites (Xxxx et al., 1991). SR proteins were first identified by their intrinsic ability to activate splicing through complementation assays with cytoplasmic S100 splicing- deficient extracts from HeLa cells containing all splicing machinery except SR proteins (Xxxxxx et al., 1992).
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