Regulation of alternative splicing Sample Clauses

Regulation of alternative splicing. The spliceosome catalyses the splicing reaction to remove introns through accurate recognition of cis-acting elements as well as donor and acceptor sites (5’-, 3’-splice sites respectively) found at the intron-exon boundaries of pre- mRNA (Figure 1.3) (Mount, 1982). Also present within the intron is the branch point (A) and polypyrimidine (polyY) tract which are important as early entry point of the spliceosome and removal of the intron (Figure 1.3). In addition to these splicing signals, splicing regulation involves regulatory cis-acting elements in both exons and introns. These are divided into four categories: exonic splicing enhancer (ESE), exonic splicing silencer (ESS), intronic splicing enhancer (ISE) and intronic splicing silencer (ISS) (Figure 1.3).
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