Application of Toxicological Guidance Values Sample Clauses

Application of Toxicological Guidance Values. Toxicological guidance values can be Acceptable Daily Intake (ADI) for food additives, pesticides and veterinary drugs, and Tolerable Daily Intake (TDI), Provisional Tolerable Weekly Intake (PTWI) and Provisional Tolerable Monthly Intake (PTMI) for other contaminants. For veterinary drug and pesticide residues, maximum residue levels (MRLs) are derived from controlled studies and are generally established so that the theoretical maximum daily intake of residues (calculated by any of several accepted methods) does not exceed the ADI. For environmental contaminants Risk Assessment Risk Analysis and other chemicals that appear in food, regulatory standards often define “permissible levels” (or maximum levels (MLs) established by risk managers). In assessing the risks of these hazards it is recognized that as a practical matter it is often neither economically nor technically feasible to apply the same “notional zero risk” model to unavoidable contaminants as to other chemicals in the food supply. MLs are generally set so that the estimated intake does not exceed the TDI or PTWI. Risk managers may ask the risk assessors to compare the health protection impact of different proposed MLs. In such cases, the risk assessors focus on the exposure assessment to provide a more in-depth scientific basis for the risk management choices.
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