Antagonist definition

Antagonist means one or more (either alone or together) of any opioid receptor antagonist, including [* * *].
Antagonist means a small molecule that blocks or inhibits the activation of mGlu2-R.
Antagonist means any molecule that can prevent, neutralize, inhibit or reduce a targeted activity, i.e., the activity of a cytokine such as IL-17 or IL-23, either in vitro or in vivo. Cytokine antagonists include, but are not limited to, antagonistic antibodies, peptides, peptide-mimetics, polypeptides, and small molecules that bind to a cytokine (or any of its subunits) or its functional receptor (or any of its subunits) in a manner that interferes with cytokine signal transduction and downstream activity. Examples of peptide and polypeptide antagonists include truncated versions or fragments of the cytokine receptor (e.g., soluble extracellular domains) that bind to the cytokine in a manner that either reduces the amount of cytokine available to bind to its functional receptor or otherwise prevents the cytokine from binding to its functional receptor. Antagonists also include molecules that prevent expression of any subunit that comprises the cytokine or its receptor, such as, for example, antisense oligonucleotides which target mRNA, and interfering messenger RNA, (see, e.g., Arenz and Schepers (2003) Naturwissenschaften 90:345-359; Sazani and KoIe (2003) . Clin. Invest.

Examples of Antagonist in a sentence

  • Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial.

  • Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan.

  • Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients with Type 2 Diabetes: 12- and 24-Week Phase 2 Studies.

  • Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer.

  • The Antagonist of the Theodicy: Sceptcism Before moving on to examine Leibniz’s apologetic arguments, it is worth briefly reflecting, in the light of the elements which have emerged in the course of this chapter, on the real identity of the antagonist being addressed in the Theodicy.

  • Required Reporting of Annual Review by Osteopathic Physicians of Dispensing Practices of Those Authorized to Dispense an Opiate Antagonist.

  • Required Reporting of Annual Review of Physician of Dispensing Practices of Those Authorized to Dispense an Opiate Antagonist.

  • Janine Zacharia, “U.S. Finds an Antagonist in a Country on the Rise,” International Herald Tribune, June 27, 2007.

  • Blocking of the PD-1/PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immu- notherapy.

  • A pharmacy that assembles opioid antagonist rescue kits shall affix a label to the outer package noting “Opioid Antagonist Rescue Kit” and the expiration date, which shall be based on the expiration dated of the included naloxone hydrochloride unit.


More Definitions of Antagonist

Antagonist a substance which reduces or prevents the effect of an agonist at a receptor site;

Related to Antagonist

  • Opioid antagonist means a drug that binds to opioid

  • Receptor means any human, plant, animal, or structure which is, or has the potential to be, affected by the release or migration of contaminants. Any well constructed for the purpose of monitoring groundwater and contaminant concentrations shall not be considered a receptor.

  • Vaccine means a specially prepared antigen which, upon administration to a person, will result in immunity and, specifically for the purposes of this rule, shall mean influenza and pneumococcal vaccines.

  • Opioid means a drug that produces an agonist effect on opioid receptors and is indicated or used for the treatment of pain.

  • Gene means the General Rules 2005.general insurance businessmeans insurance business in relation to general insurance contracts.general insurance contractmeans a contract of insurance that is a General Insurance Contract under the Financial Services Regulations, schedule 3, part 3, paragraph 10.3.Governing BodyThe board of Directors, committee of management or other governing body of an Authorised Firm.government or public securitymeans a debt instrument issued by or on behalf of—(a) a jurisdiction; or(b) a public, regional or local authority of ajurisdiction.Gross Written Premium(1) In relation to a Contract of Insurance, the amount of premium payable by the insured in respect of that contract, excluding any excise taxes levied on premiums and receivable by the Insurer but without any deduction for commissions or other acquisition expenses; and(2) in relation to an Insurer during a period:(A) in respect of General Insurance Business, the aggregate amount of Gross Written Premium in respect of insurance and reinsurance contracts entered into by the Insurer as Insurer during that period, together with any adjustments arising in that period in respect of contracts effected in previous periods; and(B) in respect of Long Term Insurance Business, the aggregate amount of Gross Written Premium becoming due for payment in thatperiod.GroupWith respect to an Entity:(A) that Entity;(B) any Parent Entity of the Entity; and(C) any Subsidiary (direct or indirect) of that Entity or of any Parent Entity of that Entity.Group RiskThe risk of loss to the Authorised Firm as a result of its membership of, or linkages within a Group.

  • Cannabinoid means any of the chemical compounds that are the active constituents of marijuana.

  • Gene Therapy means the introduction of a nucleic acid sequence encoding a protein intended for or otherwise conferring therapeutic benefit into a person for therapeutic purposes (i) by in vivo introduction for incorporation into cells of such person, or (ii) by ex vivo introduction into cells for transfer into a person.

  • Antibody means a molecule or a gene encoding such a molecule comprising or containing one or more immunoglobulin variable domains or parts of such domains or any existing or future fragments, variants, modifications or derivatives thereof.

  • Cannabinoid edible means food or potable liquid into which a cannabinoid concentrate, cannabinoid extract or dried marijuana leaves or flowers have been incorporated.

  • Anabolic steroid means any drug or hormonal substance, chemically and pharmacologically related

  • Preceptor means an individual who provides, directs, or verifies training and experience required for an individual to become an authorized user, an authorized medical physicist, an authorized nuclear pharmacist, or a radiation safety officer.

  • Precursor means any chemical reactant which takes part at any stage in the production by whatever method of a toxic chemical. This includes any key component of a binary or multicomponent chemical system.

  • Corrosion inhibitor means a substance capable of reducing the corrosivity of water toward metal plumbing materials, especially lead and copper, by forming a protective film on the interior surface of those materials.

  • Antigen means a substance recognized by the body as being foreign; it results in the production of specific antibodies directed against it.

  • coronavirus means severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);

  • Therapeutic diet means meals served that are soft, low-fat, low-sodium or controlled calorie.

  • Tetrahydrocannabinol means the natural or synthetic equivalents of the substances contained in the plant, or in the resinous extractives of, Cannabis sativa, or any synthetic substances, compounds, salts, or derivatives of the plant or chemicals and their isomers with similar chemical structure and pharmacological activity.

  • Nematode means invertebrate animals of the phylum nemathelminthes, and class nematoda, i.e., unsegmented round worms with elongated, fusiform, or saclike bodies covered with cuticle, and inhabiting soil, water, plants, or plant parts, may also be called nemas or eelworms.

  • Vector means a carrier that is capable of transmitting a pathogen from one organism to another including, but not limited to, flies and other insects, rodents, birds, and vermin.

  • Diagnostic mammography means a method of screening that

  • Pathogen means an organism that is capable of producing an infection or disease in a susceptible host.

  • Strain means the classification of marijuana or cannabis plants in either pure sativa, indica, afghanica, ruderalis, or hybrid varieties.

  • haemophilia means an inheritable disease, usually affecting only male but transmitted by women to their male children, characterised by loss or impairment of the normal clotting ability of blood so that a minor would may result in fatal bleeding;

  • Cardiopulmonary resuscitation (CPR) means measures to restore cardiac function or to support breathing in the event of cardiac or respiratory arrest or malfunction. “CPR” includes, but is not limited to, artificial ventilation, chest compression, delivering electric shock, placing tubes in the airway to assist breathing or other basic and advanced resuscitative therapies.

  • Diagnostic Product means an assemblage of reagents, including but not limited to reagents packaged in the form of a kit, useful in performing a Licensed Service.

  • HBV means hepatitis B virus.