Antagonist definition

Antagonist means one or more (either alone or together) of any opioid receptor antagonist, including [* * *].
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Antagonist means a small molecule that blocks or inhibits the activation of mGlu2-R.
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Antagonist means any molecule that can prevent, neutralize, inhibit or reduce a targeted activity, i.e., the activity of a cytokine such as IL-17 or IL-23, either in vitro or in vivo. Cytokine antagonists include, but are not limited to, antagonistic antibodies, peptides, peptide-mimetics, polypeptides, and small molecules that bind to a cytokine (or any of its subunits) or its functional receptor (or any of its subunits) in a manner that interferes with cytokine signal transduction and downstream activity. Examples of peptide and polypeptide antagonists include truncated versions or fragments of the cytokine receptor (e.g., soluble extracellular domains) that bind to the cytokine in a manner that either reduces the amount of cytokine available to bind to its functional receptor or otherwise prevents the cytokine from binding to its functional receptor. Antagonists also include molecules that prevent expression of any subunit that comprises the cytokine or its receptor, such as, for example, antisense oligonucleotides which target mRNA, and interfering messenger RNA, (see, e.g., Arenz and Schepers (2003) Naturwissenschaften 90:345-359; Sazani and KoIe (2003) . Clin. Invest.
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Examples of Antagonist in a sentence

  • Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial.

  • Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer.

  • Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan.

  • The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist.

  • Being run by a project team from Portsmouth City Council, these installations are scheduled to be completed by mid-April 2021.

  • Cerebrovascular and Cerebral Metabolic Effects of Physostigmine, Midazolam and a Benzodiazepine Antagonist," W.E. Hoffman, R.F. Albrecht, D.J. Miletich, T.J. Hagen, and J.M. Cook, Anesth.

  • A Benzodiazepine Antagonist Inhibits the Cerebral Metabolic and Respiratory Depressant Effects of Fentanyl," N.

  • Interactions Between the Benzodiazepine Receptor Antagonist Ro 15-1788 (Flumazenil) and the Inverse Agonist BCCE: Behavioral Studies with Squirrel Monkeys," J.E. Barrett, L.S. Brady, J.M. Witkin, J.M. Cook, and P.

  • Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients with Type 2 Diabetes: 12- and 24-Week Phase 2 Studies.

  • Midazolam-Ethanol Interactions and Reversal with a Benzodiazepine Antagonist," P.


More Definitions of Antagonist

Antagonist a substance which reduces or prevents the effect of an agonist at a receptor site;
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Related to Antagonist

  • Opioid antagonist means a drug that binds to opioid

  • Receptor means enclosed spaces, conduits, protected groundwater sources, drinking and non-drinking water wells, surface water bodies, and public water systems which when impacted by chemicals of concern may result in exposure to humans and aquatic life, explosive conditions or other adverse effects on health, safety and the environment as specified in these rules.

  • Vaccine means a specially prepared antigen which, upon administration to a person, will result in immunity and, specifically for the purposes of this rule, shall mean influenza and pneumococcal vaccines.

  • Opioid means a drug that produces an agonist effect on opioid receptors and is indicated or used for the treatment of pain.

  • Cannabinoid means any of the chemical compounds that are the active constituents of marijuana.

  • Gene Therapy means a product or service for the treatment or prevention of a disease that utilizes ex vivo or in vivo delivery (via viral or nonviral gene transfer methods or systems) of Genetic Material, including any cell incorporating Genetic Material.

  • Antibody means a molecule or a gene encoding such a molecule comprising or containing one or more immunoglobulin variable domains or parts of such domains or any existing or future fragments, variants, modifications or derivatives thereof.

  • Cannabinoid edible means food or potable liquid into which a cannabinoid concentrate, cannabinoid extract or dried marijuana leaves or flowers have been incorporated.

  • Opioid antidote means any drug, regardless of dosage amount or method of administration, which has been approved by the United States Food and Drug Administration (FDA) for the treatment of an opioid overdose. “Opioid antidote” includes, but is not limited to, naloxone hydrochloride, in any dosage amount, which is administered through nasal spray or any other FDA-approved means or methods.

  • Anabolic steroid means any drug or hormonal substance, chemically and pharmacologically related

  • Preceptor means an individual who provides, directs, or verifies training and experience required for an individual to become an authorized user, an authorized medical physicist, an authorized nuclear pharmacist, or a radiation safety officer.

  • Precursor means any chemical reactant which takes part at any stage in the production by whatever method of a toxic chemical. This includes any key component of a binary or multicomponent chemical system.

  • Corrosion inhibitor means a substance capable of reducing the corrosivity of water toward metal plumbing materials, especially lead and copper, by forming a protective film on the interior surface of those materials.

  • Antigen means a substance recognized by the body as being foreign; it results in the production of specific antibodies directed against it.

  • coronavirus means severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);

  • Biomarker means a parameter or characteristic in a patient or Patient Sample, the measurement of which is useful (a) for purposes of selecting appropriate therapies or patient populations or monitoring disease susceptibility, severity or state, or monitoring therapies for such patient and/or (b) for predicting the outcome of a particular treatment of such patient.

  • Therapeutic diet means meals served that are soft, low-fat, low-sodium or controlled calorie.

  • Tetrahydrocannabinol means the natural or synthetic equivalents of the substances contained in the plant, or in the resinous extractives of, Cannabis sativa, or any synthetic substances, compounds, salts, or derivatives of the plant or chemicals and their isomers with similar chemical structure and pharmacological activity.

  • Nematode means invertebrate animals of the phylum nemathelminthes, and class nematoda, i.e., unsegmented round worms with elongated, fusiform, or saclike bodies covered with cuticle, and inhabiting soil, water, plants, or plant parts, may also be called nemas or eelworms.

  • Vector means a carrier that is capable of transmitting a pathogen from one organism to another including, but not limited to, flies and other insects, rodents, birds, and vermin.

  • Diagnostic mammography means a method of screening that

  • Pathogen means an organism that is capable of producing an infection or disease in a susceptible host.

  • Strain means the classification of marijuana or cannabis plants in either pure sativa, indica, afghanica, ruderalis, or hybrid varieties.

  • haemophilia means an inheritable disease, usually affecting only male but transmitted by women to their male children, characterised by loss or impairment of the normal clotting ability of blood so that a minor would may result in fatal bleeding;

  • Cardiopulmonary resuscitation or "CPR" means artificial ventilation or external

  • Diagnostic Product means any test or assay for diagnosing or detecting a disease, disorder, medical condition, or symptom.