Singular Genomics Systems, Inc. Sample Contracts

SINGULAR GENOMICS SYSTEMS, INC. COMMON STOCK SALES AGREEMENT
Sales Agreement • July 19th, 2022 • Singular Genomics Systems, Inc. • Laboratory analytical instruments • New York

Singular Genomics Systems, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Cowen and Company, LLC (“Cowen”), as follows:

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LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • May 7th, 2021 • Singular Genomics Systems, Inc. • Laboratory analytical instruments • Delaware

THIS LOAN AND SECURITY AGREEMENT (this “Agreement”) dated as of November 19, 2019 (the “Effective Date”) between SILICON VALLEY BANK, a California corporation (“Bank”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Borrower”), provides the terms on which Bank shall lend to Borrower and Borrower shall repay Bank. The parties agree as follows:

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LEASE AGREEMENT
Lease Agreement • May 7th, 2021 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

THIS LEASE AGREEMENT (this “Lease”) is made this 26th day of June, 2020, between ARE-SD REGION NO. 27, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Tenant”).

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INDENTURE between SINGULAR GENOMICS SYSTEMS, INC. as Issuer and [TRUSTEE] as Trustee Dated as of , 20 Providing for the Issuance of Debt Securities in Series
Indenture • July 19th, 2022 • Singular Genomics Systems, Inc. • Laboratory analytical instruments • New York

INDENTURE, dated as of , 20 , between SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation, as Issuer (the “Company”), having its principal office at 3010 Science Park Road, San Diego, California 92121, and [TRUSTEE], a New York banking corporation, as Trustee (the “Trustee”).

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AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • November 9th, 2021 • Singular Genomics Systems, Inc. • Laboratory analytical instruments
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EXCHANGE AGREEMENT
Exchange Agreement • January 26th, 2022 • Singular Genomics Systems, Inc. • Laboratory analytical instruments • Delaware

This EXCHANGE AGREEMENT (including the schedules, annexes and exhibits hereto, this “Agreement”), dated as of January 26, 2022, is entered into by and among Singular Genomics Systems, Inc., a Delaware corporation (the “Company”) and Deerfield Private Design Fund IV, L.P. (the “Holder”).

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LEASE AGREEMENT
Lease Agreement • May 10th, 2022 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

THIS LEASE AGREEMENT (this “Lease”) is made this 19 day of January, 2022, between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Tenant”).

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SUBLEASE
Singular Genomics Systems, Inc. • May 7th, 2021 • Laboratory analytical instruments • California
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SECOND AMENDMENT TO LEASE AGREEMENT THIS SECOND AMENDMENT TO LEASE AGREEMENT (this “Second Amendment”) is made this
Lease Agreement • November 14th, 2023 • Singular Genomics Systems, Inc. • Laboratory analytical instruments
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EXCLUSIVE LICENSE AGREEMENT
License Agreement • May 7th, 2021 • Singular Genomics Systems, Inc. • Laboratory analytical instruments • New York

AGREEMENT, dated August 12, 2016 (the “Effective Date”), between THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, a New York corporation (“Columbia”), and Singular Genomics Systems, Inc. , a Delaware corporation (“Company”).

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SIXTH AMENDMENT TO LEASE
To Lease • November 14th, 2023 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

THIS SIXTH AMENDMENT TO LEASE (this “Sixth Amendment”) is made as of July 19, 2023, by and between ARE-SD REGION NO. 35, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Tenant”).

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THIRD AMENDMENT TO LEASE
Lease • November 14th, 2023 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

THIS THIRD AMENDMENT TO LEASE (this "Third Amendment") is made as of June 19, 2020, by and between ARE-SD REGION NO. 35, LLC, a Delaware limited liability company ("Landlord"), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation ("Tenant").

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CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND is the type of information that the registrant treats as private and Confidential, AND HAS BEEN MARKED WITH “[***]” TO INDICATE WHERE OMISSIONS HAVE...
Loan and Security Agreement • November 7th, 2022 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

This First Amendment to Amended and Restated Loan and Security Agreement (this “Amendment”) is entered into this 30th day of September, 2022, by and between Silicon Valley Bank (“Bank”) and Singular Genomics Systems, Inc., a Delaware corporation (“Borrower”), whose address is 10931 N. Torrey Pines Road, La Jolla, California 92037.

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Contract
Warrant to Purchase Stock • May 7th, 2021 • Singular Genomics Systems, Inc. • Laboratory analytical instruments • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR IN FORM AND SUBSTANCE SATISFACTORY TO THE COMPANY, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

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Singular Genomics Systems, Inc. February 28, 2023
Singular Genomics Systems, Inc. • March 2nd, 2023 • Laboratory analytical instruments • California

This letter confirms the agreement (“Agreement”) between you and Singular Genomics Systems, Inc. (the “Company”) concerning the terms of your separation from employment and offers you certain benefits to which you would not otherwise be entitled, conditioned upon your provision of a general release of claims and covenant not to sue as provided herein. If you agree to the terms outlined herein, please sign and return this Agreement to me in the timeframe outlined below.

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FOURTH AMENDMENT TO LEASE
To Lease • November 14th, 2023 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

THIS FOURTH AMENDMENT TO LEASE (this “Fourth Amendment”) is made as of April 20, 2021, by and between ARE-SD REGION NO. 35, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Tenant”).

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LEASE AGREEMENT
Lease Agreement • November 14th, 2023 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

THIS LEASE AGREEMENT (this "Lease") is made this 15 day of November, 2019, between ARE-SD REGION NO. 35, LLC, a Delaware limited liability company ("Landlord"), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation ("Tenant").

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FIRST AMENDMENT TO AGREEMENT FOR TERMINATION OF LEASE
Singular Genomics Systems, Inc. • November 14th, 2023 • Laboratory analytical instruments

Amendment”) is made as of August 31, 2023, by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Tenant”).

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FIRST AMENDMENT TO LEASE
Lease • November 14th, 2023 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

THIS FIRST AMENDMENT TO LEASE (this "First Amendment") is made as of February 24, 2020, by and between ARE..SD REGION NO. 35, LLC, a Delaware limited liability company ("Landlord"), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation ("Tenant").

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AGREEMENT FOR TERMINATION OF LEASE
Agreement for Termination of Lease • November 14th, 2023 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

This Agreement for Termination of Lease (this “Agreement”) is made and entered into as of July 19, 2023, by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Tenant”), with reference to the following:

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September 25, 2019
Singular Genomics Systems, Inc. • May 7th, 2021 • Laboratory analytical instruments
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FIFTH AMENDMENT TO LEASE
To Lease • November 14th, 2023 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

THIS FIFTH AMENDMENT TO LEASE (this “Fifth Amendment”) is made as of January _19_, 2022, by and between ARE-SD REGION NO. 35, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Tenant”).

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SECOND AMENDMENT TO LEASE
Lease • November 14th, 2023 • Singular Genomics Systems, Inc. • Laboratory analytical instruments

May 7, 2020, by and between ARE-SD REGION NO. 35, LLC, a Delaware limited liability company ("Landlord"), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation ("Tenant").

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SINGULAR GENOMICS SYSTEMS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT June 27, 2019
Investors’ Rights Agreement • May 7th, 2021 • Singular Genomics Systems, Inc. • Laboratory analytical instruments • California

This AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (the “Agreement”) is made as June 27, 2019, by and among Singular Genomics Systems, Inc., a Delaware corporation (the “Company”), the investors listed on Schedule A hereto, each of which is herein referred to as an “Investor” and collectively as the “Investors”, and each of the stockholders listed on Schedule B hereto, each of whom is herein referred to as a “Common Holder” and collectively as the “Common Holders”.

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