Teriparatide and PTH 1 Sample Clauses

Teriparatide and PTH 1. 84 Parathyroid hormone 1-34 (teriparatide, PTH-34) and PTH 1-84 belong to a class of drugs called anabolic agents [223]. Parathyroid hormone (PTH) is an 84-amino acid polypeptide secreted by the parathyroid glands in response to small changes in serum calcium [224]. Teriparatide is a recombinant PTH and is used to treat OP by stimulation of bone formation [223-225]. The mechanism of teriparatide is to stimulate new bone formation on inactive bone surfaces, while stimulating bone turnover by the classic remodelling cycle involving both osteoclastic resorption and osteoblastic reformation [224]. Teriparatide improves skeletal architecture; bone is gained, which is recognised as increased trabecular thickness and connectivity [226, 227].
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