SR protein expression Sample Clauses

SR protein expression is developmentally regulated SR proteins are known to be the limiting factor in alternative splicing and show changes in their expression levels during development (Xxxxx et al., 1994; Xxxxxx et al., 1992; Xxxxxx et al., 1993). SR proteins are localised and enriched in nuclear speckles (Fu, 1995). Nuclear speckles are storage compartments for splicing factors, which respond to the level of transcription by RNA polymerase II (Xxxxxxx et al., 1997). The RS domains of SR proteins act as a localisation signal into nuclear speckles before they are recruited to splicing sites during constitutive or alternative splicing (Hedley et al., 1995). A gradual decline of the SR protein, ASF was observed from embryonic stages to adult rat brain (Xxxxx et al., 1999). In addition, the level of tra2-β1 decreased from embryonic rat brain (E14, E16, E18, and E20) to postnatal stages (P5, P15 and P20) and adult rat brain (Xxxxx et al., 1999).
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