Common use of Research Plans Clause in Contracts

Research Plans. Each Research Plan directed toward a Collaboration Construct, shall allocate Research responsibilities between the Parties, and shall set forth the objectives, activities and criteria for evaluation for such Research, as well as timelines related thereto. In addition to the foregoing, each Research Plan directed toward a Targeted Collaboration Construct shall also designate the Target of the Targeted Collaboration Construct (a “Research Target”) [***]; provided, that the Targets or pairs of Targets listed on Exhibit L shall not, and cannot, be designated as Research Targets. Each Party shall, in performing its obligations under each Research Plan, assign responsibilities to those portions of its organization that have the appropriate resources, expertise, and responsibility for such obligations. As of the Effective Date, the Parties have agreed upon two initial research plans (each an “Initial Research Plan”) attached to this Agreement as Exhibit A and Exhibit B, which will be deemed to have been approved by the JRC. From time to time during the Research Term, the JRC shall prepare updates and amendments, as appropriate, to the then-current Research Plan(s) and may approve new Research Plans as may be proposed by either Party or the JRC. The JRC shall have the right to approve updates and amendments to a Research Plan in accordance with Section ‎2.2.1. Once approved by the JRC, such revised Research Plan shall replace the prior Research Plan. If the terms of a Research Plan contradict, or create inconsistencies or ambiguities with, the terms of this Agreement, then the terms of this Agreement shall govern. CONFIDENTIALEXECUTION COPY

Research Plans. The Parties agree to collaborate on up to [***] Research Programs, each in accordance with a Research Plan. iTeos may nominate [***] Target for each Research Program by completing a Target Questionnaire and delivering it to Adimab during the Target Nomination Period. Upon completion of a Target Questionnaire by iTeos, the Parties shall agree to a Research Plan setting forth the expected timeline, budget, and relevant deliverables from initial discovery and from optimization of Program Antibodies. In addition, each Research Plan will set forth the criteria for achieving the Technical Milestone II Criteria described in Section 4.2(b) (Technical Milestone), which criteria shall be of the type that Adimab currently has the capability of analytically measuring, such as affinity and epitopic coverage, and such attributes shall not include any sort of measurement of biological functionality. Such Research Plan shall be based upon the form of Research Plan attached hereto as Exhibit B, and shall include Adimab’s responsibilities with respect to the discovery and optimization of antibodies with respect to each Target. Each Research Plan directed toward a Collaboration Construct, shall allocate Research responsibilities between be agreed upon in writing by the Parties, and each Research Program shall set forth be conducted in accordance therewith. Neither Party is required to perform a Research Program under this Agreement if the objectives, activities and criteria for evaluation for Parties do not mutually agree in writing on a Research Plan. Adimab’s obligation to perform such Research, as well as timelines related thereto. In addition additional Research Programs shall be subject to the foregoing, each availability of Adimab researchers to perform such Research Plan directed toward a Targeted Collaboration Construct shall also designate the Target of the Targeted Collaboration Construct (a “Research Target”) [***]Program; provided, however, that the Targets or pairs in no event shall Adimab be permitted to delay performance of Targets listed such Research Programs for more than two (2) months after mutual agreement on Exhibit L shall not, and cannot, be designated as Research Targets. Each Party shall, in performing its obligations under each such Research Plan, assign responsibilities to those portions of its organization that have the appropriate resources, expertise, and responsibility for such obligations. As of the Effective Date, the Parties have agreed upon two initial research plans (each an “Initial Research Plan”) attached to this Agreement as Exhibit A and Exhibit B, which will be deemed to have been approved by the JRC. From time to time during the Research Term, the JRC shall prepare updates and amendments, as appropriate, to the then-current Research Plan(s) and may approve new Research Plans as may be proposed by either Party or the JRC. The JRC shall have the right to approve updates and amendments to a Research Plan in accordance with Section ‎2.2.1. Once approved by the JRC, such revised Research Plan shall replace the prior Research Plan. If the terms of a Research Plan contradict, or create inconsistencies or ambiguities with, the terms of this Agreement, then the terms of this Agreement shall govern. CONFIDENTIALEXECUTION COPY.

Research Plans. Each The Parties agree to initially collaborate on [***] Research Plan directed toward a Collaboration Construct, shall allocate Research responsibilities between the Parties, and shall set forth the objectives, activities and criteria for evaluation for such Research, as well as timelines related thereto. In addition to the foregoingPrograms, each in accordance with a Research Plan directed toward Plan; provided, however, that in the event ​ ​ ​ that Flame exercises the Extension Option, the Parties will collaborate on an additional [***] Research Programs for a Targeted Collaboration Construct total of [***] Research Programs. Flame shall also designate nominate one Target for each Research Program by completing a Target Questionnaire and delivering it to Adimab during the Target of Discovery Term. Flame shall nominate [***] Targets within [***] and, if Flame exercises the Targeted Collaboration Construct (a “Research Target”) Extension Option, Flame shall nominate the remaining [***] Targets no later than [***]; provided, that the Targets or pairs . Upon completion of Targets listed on Exhibit L shall not, and cannot, be designated as Research Targets. Each Party shall, in performing its obligations under each Research Plan, assign responsibilities to those portions of its organization that have the appropriate resources, expertise, and responsibility for such obligations. As of the Effective Datea Target Questionnaire by Flame, the Parties have agreed upon two initial research plans (each an “Initial Research Plan”) attached to this Agreement as Exhibit A and Exhibit B, which will be deemed to have been approved by the JRC. From time to time during the Research Term, the JRC shall prepare updates and amendments, as appropriate, to the then-current Research Plan(s) and may approve new Research Plans as may be proposed by either Party or the JRC. The JRC shall have the right to approve updates and amendments agree to a Research Plan setting forth the expected timeline, budget, and relevant deliverables from initial discovery and from optimization of Program Antibodies. In addition, each Research Plan will set forth the criteria for achieving the technical milestone described in accordance with Section ‎2.2.14.2(b) (Technical Milestone), which criteria shall be [***]. Once approved by the JRC, such revised Such Research Plan shall replace be based upon the prior form of Research Plan attached hereto as Exhibit B, and shall include Adimab’s responsibilities with respect to the discovery and optimization of antibodies with respect to each Target. Each Research Plan shall be agreed upon in writing by the Parties, and each Research Program shall be conducted in accordance therewith. Neither Party is required to perform a Research Program under this Agreement if the Parties do not mutually agree in writing on Research Plan. If the terms Adimab shall not unreasonably withhold its approval of a Research Plan. In the event that Adimab does not approve a Research Plan contradict, or create inconsistencies or ambiguities with, the terms proposed by ▇▇▇▇▇ as [***]of this Agreementsuch proposal, then the terms Target contemplated by such Research Plan shall not count in calculating the number of this Agreement Targets on which the Parties shall govern. CONFIDENTIALEXECUTION COPYcollaborate hereunder.

Research Plans. Each The Parties agree to initially collaborate on [***] Research Plan directed toward a Collaboration Construct, shall allocate Research responsibilities between the Parties, and shall set forth the objectives, activities and criteria for evaluation for such Research, as well as timelines related thereto. In addition to the foregoingPrograms, each in accordance with a Research Plan directed toward a Targeted Collaboration Construct shall also designate Plan; provided, however, that in the Target of event that Leap exercises the Targeted Collaboration Construct (a “Research Target”) Extension Option, the Parties will collaborate on an additional [***]; provided, that the Targets or pairs of Targets listed on Exhibit L . Leap shall not, and cannot, be designated as Research Targets. Each Party shall, in performing its obligations under nominate one Target for each Research PlanProgram by completing a Target Questionnaire and delivering it to Adimab during the Discovery Term. Leap shall nominate [***] and, assign responsibilities to those portions if Leap exercises the Extension Option, Leap shall nominate the remaining [***] Targets no later than [***]. Upon completion of its organization that have the appropriate resources, expertise, and responsibility for such obligations. As of the Effective Datea Target Questionnaire by ▇▇▇▇, the Parties have agreed upon two initial research plans (each an “Initial Research Plan”) attached to this Agreement as Exhibit A and Exhibit B, which will be deemed to have been approved by the JRC. From time to time during the Research Term, the JRC shall prepare updates and amendments, as appropriate, to the then-current Research Plan(s) and may approve new Research Plans as may be proposed by either Party or the JRC. The JRC shall have the right to approve updates and amendments agree to a Research Plan setting forth the expected timeline, budget, and relevant deliverables from initial discovery and from optimization of Program Antibodies. In addition, each Research Plan will set forth the criteria for achieving the technical milestone described in accordance with Section ‎2.2.14.2(b) (Technical Milestone), which criteria shall be [***]. Once approved by the JRC, such revised Such Research Plan shall replace be based upon the prior form of Research Plan attached hereto as Exhibit B, and shall include Adimab’s responsibilities with respect to the discovery and optimization of antibodies with respect to each Target. Each Research Plan shall be agreed upon in writing by the Parties, and each Research Program shall be conducted in accordance therewith. Neither Party is required to perform a Research Program under this ​ Agreement if the Parties do not mutually agree in writing on Research Plan. If the terms Adimab shall not unreasonably withhold its approval of a Research Plan. In the event that Adimab does not approve a Research Plan contradict, or create inconsistencies or ambiguities with, the terms proposed by ▇▇▇▇ as [***] of this Agreementsuch proposal, then the terms Target contemplated by such Research Plan shall not count in calculating the number of this Agreement Targets on which the Parties shall govern. CONFIDENTIALEXECUTION COPYcollaborate hereunder.