Micelles/dendrimers Sample Clauses

Micelles/dendrimers. Micelles are self-assembling nanosized colloidal particles with a hydrophobic core and hydrophilic shell (Xxxxxxxxx, 2007). At low concentrations, the amphiphiles exist as monomers. Above the critical micelle concentration (CMC), the monomers self-assemble to form micelles. Micelles are used as carriers of poorly soluble compounds where solubilization occurs in the micelle core. Xxxx et al. (2011) evaluated the potential of paclitaxel loaded micelles fabricated from PEG5000 as a sustained release system following pulmonary delivery (Xxxx et al., 2011). The results showed the micelles retarded paclitaxel release over 8 h in vitro. More recently, Xx et al. (2014) showed aerosolized PEG–PLGA micelles were a promising carrier for pulmonary sustained release of labile drugs (Xx et al., 2014). Dendrimers are three-dimensional structures similar to micelles, also known as unimolecular micelles, which have been proved as successful carriers in different routes of drug administration (Xxxxx et al., 2008). Several studies have shownthat dendrimers can sustain drug release within the airway tract. Xxxxxxxxx et al. (2014) explored the conjugation of a 56 kDa PEGylated polylysine dendrimer to doxorubicin to promote the controlled and prolonged exposure of lung-resident cancers to cytotoxic drug (Xxxxxxxxx et al., 2014). The dendrimer sustained doxorubicin in the lungs for 7 days compared to rapid absorption of free drug.
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