Examples of IHC in a sentence
IHC results obtained from patients screened or enrolled in the Phase 1 Study IMGN853-0401 and Phase 3 Study IMGN853-403 are generally consistent with the literature (Investigator Brochure).
Second, both Xxxxx et al and Xxxxx et al have demonstrated that recurrent tumors retain FRα expression comparably to primary tumors as shown by serial biopsy sampling and IHC (Xxxxx 2008, Xxxxx 2012).
Eligible patients were required to have tumors expressing what was considered a medium or high level FRα expression per the Ventana IHC assay using a newly implemented “10x” scoring method.
Subsequent review demonstrated that the “10x” scoring method for the FOLR1 IHC assay misclassified a significant percentage of patients, and thus further impacted the study results.
Published studies have demonstrated FRα overexpression by immunohistochemistry (IHC) in various epithelial tumors, particularly serous and endometrioid ovarian cancers and serous and endometrioid endometrial cancers (Scorer 2010, Xxxxx-Xxxxx 1993, Xxxxx 2008, Xxxxx 2012, Xxxxxx 2007, Xxxxx 2008, Ab 2015, and Xxxxxx 2007).