CMR ASSESSMENT OF ISCHAEMIC BURDEN Sample Clauses

CMR ASSESSMENT OF ISCHAEMIC BURDEN. Most of the studies using ischaemic burden have traditionally used SPECT as the non-invasive imaging modality. There is some evidence(74) that the prognostic threshold for significant ischaemia applies to CMR also, but there are no direct comparative trials related to this. In preliminary analysis of 10 patients who underwent CMR and SPECT scanning, the mean percentage of inducible ischaemia was 7.3% (range 0-22.2%) for CMR and 10.3% for SPECT (range 0-25.0%). Overall there was no significant difference (P=0.47) (74) In a recent study, Xxxxxx et al measured ischaemic burden by visual analysis of CMR images(75) demonstrating good correlation with the Duke Jeopardy score (r=0.82). Xxxxxx et al showed that a BCIS score ≥6 predicts an ischaemia threshold of 12% on CMR with high specificity (76). However, both of these studies have used an anatomical score, without correction for haemodynamic relevance and, as mentioned earlier, the concordance between anatomical severity and physiological evaluation by FFR is poor. Xxxxx et al (65) used 3D perfusion technique to compare the FFR significant lesions with the volume of myocardial hypo-enhancement. They found that a cut off value of 4.4% ischaemic burden corresponding to a FFR threshold of 0.75 resulted in a sensitivity and specificity of 86.5% and 86.3% respectively.
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