Antioxidants in the Respiratory Tract Lining Sample Clauses

Antioxidants in the Respiratory Tract Lining. Fluid Oxidative stress occurs as a result of an imbalance between production of reactive oxygen species and antioxidant defence mechanisms, a state that can damage sensitive biological targets [78]. The RTLF has a strategically important position as it is the first physical and biochemical interface encountered by inspired agents such as O3, PM, and NO2 [79, 80]. It contains high concentrations of water soluble antioxidants ascorbic acid, reduced glutathione and uric acid [73, 74], and these provide a reducing environment which can act to neutralise direct and indirect (secondary oxidation products) effects of oxidants [81]. The impairment of these antioxidant defences is thought to be involved in respiratory injury [82-84].
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