Toxic effect definition

Toxic effect means the property of an agent producing damage to an organism. This usually refers to functional (systemic) damage but may be developmental in respect of tissue and skeleton in the case of the embryo. The damage may be permanent or transient.
Toxic effect means an observable or measurable adverse biological event in an organ, tissue, or system. The designation of health endpoints does not exclude other possible observable or measurable biological events. For the purpose of grouping chemicals and creating a health risk index when multiple chemicals are present, toxic effects may be ascribed to more general health risk index endpoints or health endpoints.