CGRP definition

CGRP means any and all isoforms of the signaling peptide Calcitonin Gene-Related Peptide.

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CGRP means the compiled set of shared research quality standards defining how ▇▇▇▇▇’▇ research laboratories conduct good science for non-regulated work as set forth on the attached Schedule 1.

CGRP means calcitonin gene–related peptide, which is a protein produced by, and released by neurons. CGRP activates other neurons that are involved in pain perception. CGRP is also known to be a powerful vasodilator, causing dilation of blood vessels.

Examples of CGRP in a sentence

• Except as disclosed in Section 3.15(g) of the Company Disclosure Letter, and to the Knowledge of the Company, the Company and Company Subsidiaries own or have adequate rights to use all Intellectual Property developed, filed, registered for, used or intended to be used in the CGRP Business as presently conducted without any infringement, misappropriation or violation of the Intellectual Property of others.

• The Company or a Company Subsidiary owns all right, title and interest to and in the Owned Company Intellectual Property material to the conduct of the CGRP Business as conducted or contemplated to be conducted free and clear of any Liens, other than Permitted Liens and licenses of Intellectual Property granted under the Intellectual Property Agreements.

• Since January 1, 2020, neither the Company nor any Company Subsidiary nor any of the Company’s or any Company Subsidiary’s respective Representatives has sent or otherwise made any communication to any third party regarding any alleged or suspected infringement, misappropriation, dilution or violation of any Company Intellectual Property material to the conduct of the CGRP Business as conducted or contemplated to be conducted that is owned or exclusively licensed to the Company.

• Section 3.15(b) of the Company Disclosure Letter also identifies each proprietary Software program, trade name and unregistered Trademark, in each case, that is (x) material to the CGRP Business as presently conducted or contemplated to be conducted, and (y) owned or purported to be owned by the Company or a Company Subsidiary or licensed, either exclusively or non-exclusively, to the Company or a Company Subsidiary.

• The posterior thalamus is one of the levels of interaction between trigeminal pain modulating systems and photophobia.33 The (degree of inhibitory) action of CGRP on the nicotinic acetylcholine receptor at the synapses in photophobia circuits could be a focus for further research.

• In fact, the recent development of novel CGRP antagonists for treating migraine attacks was at least partly based on the hypothesis that prevention or reversal of vasodilation would block migraine headache 223,224.

• It is assumed to improve the signal-to-noise ratio in the synapse.32 CGRP has been linked to photophobia and thought to modulate nociception by enhancing transmission.

• Vasoactive substances such as the nitric oxide (NO) donor nitroglycerin (NTG) 78 and calcitonin gene related peptide (CGRP) 62 can trigger migraine in susceptible subjects.

• In addition to the neuromodulatory actions, CGRP has neurovascular actions.

• Furthermore, in a NTG provocation study an association between increase in plasma CGRP and the provocation of a migraine attack has been found124.

More Definitions of CGRP

CGRP means all applicable current Good Research Practices including, as applicable, (a) the research quality standards defining how Lilly’s research laboratories conduct good science for non-regulated work as set forth in Schedule 4.8 Part A of this Agreement, (b) the Research Quality Association (RQA), 2014 Quality in Research Guidelines for Working in Non-Regulated Research, (c) the WHO Quality Practices in Basic Biomedical Research Guidelines and (d) the equivalent applicable laws if any, in any relevant country, each as may be amended and applicable from time to time.