0001104659-01-501795 Sample Contracts

INVESTMENT AGREEMENT 1
Investment Agreement • August 14th, 2001 • Avi Biopharma Inc • Pharmaceutical preparations • Minnesota

THIS INVESTMENT AGREEMENT (this “Agreement”) is made and entered into as of May 22, 2001 between AVI BIOPHARMA, INC. (“AVI”), an Oregon corporation, and MEDTRONIC ASSET MANAGEMENT, INC. (“Investor”), a Minnesota corporation.

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OFFICE LEASE
Office Lease • August 14th, 2001 • Avi Biopharma Inc • Pharmaceutical preparations • Oregon

THIS OFFICE LEASE ("Lease") is made between SPIEKER PROPERTIES, L.P., a California limited partnership ("Landlord"), and AVI BIOPHARMA, INC., an Oregon corporation, ("Tenant"), as of May 8, 2001, (the "date of this Lease").

EMPLOYMENT AGREEMENT
Employment Agreement • August 14th, 2001 • Avi Biopharma Inc • Pharmaceutical preparations • Oregon

THIS EMPLOYMENT AGREEMENT ("Agreement"), made this 1st day of November, 2000, by and between AVI BioPharma, Inc. an Oregon corporation, with its principal office at 1 SW Columbia Street, Suite 1105, Portland, OR 97258 ("Company"), and David H. Mason, Jr., M.D. ("Employee").

Contract
Avi Biopharma Inc • August 14th, 2001 • Pharmaceutical preparations • Oregon

THIS WARRANT, AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE HEREOF, HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE REOFFERED OR SOLD, TRANSFERRED, PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF, EXCEPT PURSUANT TO (1) REGISTRATION OR (2) AN OPINION OF COUNSEL FOR THE COMPANY OR OTHER COUNSEL REASONABLY ACCEPTABLE TO THE COMPANY TO THE EFFECT THAT SUCH REGISTRATION IS NOT REQUIRED. THIS WARRANT IS ALSO SUBJECT TO THE TERMS OF AN INVESTMENT AGREEMENT DATED MAY 22, 2001.

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • August 14th, 2001 • Avi Biopharma Inc • Pharmaceutical preparations • Minnesota

This REGISTRATION RIGHTS AGREEMENT, dated as of June 20, 2001 (this “Agreement”), is made by and among AVI BIOPHARMA, an Oregon corporation (the “Company”), and MEDTRONIC ASSET MANAGEMENT, INC., a Minnesota corporation (“Investor”).

SUPPLY AGREEMENT 1
Supply Agreement • August 14th, 2001 • Avi Biopharma Inc • Pharmaceutical preparations • Minnesota

THIS SUPPLY AGREEMENT (the “Agreement”) is made and entered into as of June 20, 2001, (the “Effective Date”) between AVI BIOPHARMA, INC. (as defined below, “Supplier”), an Oregon corporation, and MEDTRONIC, INC. (as defined below, “Medtronic”), a Minnesota corporation.

LICENSE AND DEVELOPMENT AGREEMENT 1
License and Development Agreement • August 14th, 2001 • Avi Biopharma Inc • Pharmaceutical preparations • Minnesota

THIS LICENSE AND DEVELOPMENT AGREEMENT (this “Agreement”) is made and entered into as of June 20, 2001 between AVI BIOPHARMA, INC. (“AVI”), an Oregon corporation, and MEDTRONIC, INC. (“Medtronic”), a Minnesota corporation.

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