Summit Therapeutics Inc. Sample Contracts

SUMMIT THERAPEUTICS PLC AND THE BANK OF NEW YORK MELLON As Depositary AND OWNERS AND HOLDERS OF AMERICAN DEPOSITARY SHARES Deposit Agreement
Deposit Agreement • February 20th, 2015 • Summit Therapeutics PLC • Pharmaceutical preparations • New York

DEPOSIT AGREEMENT dated as of [Agreementdate] among SUMMIT THERAPEUTICS PLC, a company incorporated under the laws of England and Wales (herein called the Company), THE BANK OF NEW YORK MELLON, a New York banking corporation (herein called the Depositary), and all Owners and Holders (each as hereinafter defined) from time to time of American Depositary Shares issued hereunder.

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INDEMNIFICATION AGREEMENT
Indemnification Agreement • September 18th, 2020 • Summit Therapeutics Inc. • Pharmaceutical preparations • Delaware

This Agreement is made as of the [_____] day of [_______] 202[_], by and between Summit Therapeutics Inc., a Delaware corporation (the “Corporation”), and [______________] (the “Indemnitee”), a director or officer of the Corporation.

PRESCRIBED CLAUSES
Summit Therapeutics PLC • March 30th, 2017 • Pharmaceutical preparations
SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • November 7th, 2023 • Summit Therapeutics Inc. • Pharmaceutical preparations • New York

This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of October 13, 2023 by and among Summit Therapeutics Inc., a Delaware corporation, with its principal place of business at 2882 Sand Hill Road, Suite 106, Menlo Park, CA (the “Company”), and the investor named on the signature page hereto (the “Investor”).

PRIVATE & CONFIDENTIAL Ms. Elaine Stracker Dear Elaine Non-Executive Directorship - Letter of Appointment
Summit Therapeutics PLC • April 30th, 2020 • Pharmaceutical preparations

This agreement is conditional on, and shall take effect upon, Admission becoming effective and confirms the main terms and conditions of your appointment to this office. If Admission has not taken place on or before 31 December 2019, this agreement shall lapse and you shall not be appointed as a non-executive director of the Company unless otherwise appointed.

BETWEEN: RECITALS
Summit Therapeutics PLC • April 30th, 2020 • Pharmaceutical preparations • England
NOTE PURCHASE AGREEMENT
Note Purchase Agreement • April 21st, 2021 • Summit Therapeutics Inc. • Pharmaceutical preparations • New York

This NOTE PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of April 20, 2021 by and among Summit Therapeutics Inc., a Delaware corporation, with its principal place of business at One Broadway, 14th Floor, Cambridge, MA 02142 (the “Company”), and the investor named on Exhibit A hereto (the “Investor”).

DATED 19 OCTOBER 2012 TRANSLATION AWARD FUNDING AGREEMENT
Template Equity and Revenue • February 27th, 2015 • Summit Therapeutics PLC • Pharmaceutical preparations • England
DATED [•], 2020 SUMMIT THERAPEUTICS INC. and [CONSULTANT] WARRANT AGREEMENT
Warrant Agreement • September 18th, 2020 • Summit Therapeutics Inc. • Pharmaceutical preparations • Delaware
REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • November 6th, 2020 • Summit Therapeutics Inc. • Pharmaceutical preparations • New York

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made and entered into as of November 6, 2020 by and among Summit Therapeutics Inc., a Delaware corporation (the “Company”), the investor named in that certain Securities Purchase Agreement, dated November 6, 2020 by and between the Company and Polar Capital Funds plc – Biotechnology Fund, and the investor named in that certain Securities Purchase Agreement, dated November 6, 2020 by and between the Company and Mahkam Zanganeh Revocable Trust (each a “Purchase Agreement” and together the “Purchase Agreements”). Capitalized terms used herein have the respective meanings ascribed thereto in the Purchase Agreements unless otherwise defined herein.

Dated 23rd December 2017 The Management Team andDiscuva Limited TRANSFER INCENTIVE AGREEMENT
Incentive Agreement • April 13th, 2018 • Summit Therapeutics PLC • Pharmaceutical preparations • England and Wales

The Management Team have all provided support to the development of the Relevant Products of the Company and in recognition of this the Company has agreed to pay a transfer incentive payment to the Management Team in the event that the Relevant Products achieve certain milestones in their development and subject to the terms of this agreement.

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. DATED 20 September 2017
Agreement • April 13th, 2018 • Summit Therapeutics PLC • Pharmaceutical preparations • England and Wales
Contract
Summit Corp PLC • December 4th, 2014 • Pharmaceutical preparations • Massachusetts

The licensee(s) identified on the signature page of this agreement (“Licensee”, or “Client”) intends to contract with (please check one)

EQUITY AND REVENUE SHARING AGREEMENT (Seeding Drug Discovery Initiative and Translation Award)
Equity and Revenue Sharing Agreement • April 13th, 2018 • Summit Therapeutics PLC • Pharmaceutical preparations • England
DATED 16 July 2014 THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD and SUMMIT CORPORATION PLC and ISIS INNOVATION LIMITED VARIATION AGREEMENT
Variation Agreement • December 4th, 2014 • Summit Corp PLC • Pharmaceutical preparations • England and Wales

relating to the Agreement for the Sponsorship of a Research Programme for the development of small molecule modulators of utrophin for the treatment of Duchenne Muscular Dystrophy dated 22 November 2013

DATE [AGREEMENT DATE] Summit Therapeutics plc - and – [NON-EXECUTIVE DIRECTOR NAME] NON-EXECUTIVE DIRECTOR RESTRICTED STOCK UNIT (RSU) AGREEMENT (IN THE FORM OF A NOMINAL COST OPTION)
Agreement • April 13th, 2018 • Summit Therapeutics PLC • Pharmaceutical preparations

WHEREAS the Company wishes to grant to the RSU Holder a restricted stock unit (RSU) in the form of a nominal-cost option on the terms set out in this Agreement, and this RSU is intended to comply with the requirements of Section 409A of the Code.

DATED 6 DECEMBER 2019 SUMMIT THERAPEUTICS PLC and MAKY ZANGANEH & ASSOCIATES, INC. CONSULTANT WARRANT AGREEMENT
Consultant Warrant Agreement • December 6th, 2019 • Summit Therapeutics PLC • Pharmaceutical preparations
SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • December 17th, 2018 • Summit Therapeutics PLC • Pharmaceutical preparations • New York

This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of December 14, 2018 by and among Summit Therapeutics plc, a public limited company incorporated in England and Wales with the Registrar of Companies of England and Wales, with its principal place of business at 136a Eastern Avenue, Milton Park, Abingdon, Oxfordshire OX14 4SB, United Kingdom (the “Company”), and the investor named on Exhibit A hereto (the “Investor”).

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DATED 6 DECEMBER 2019 PLACING AGREEMENT RELATING TO A PLACING OF UP TO 9,221,400 ORDINARY SHARES AND 1,383,210 WARRANTS TO SUBSCRIBE FOR ORDINARY SHARES IN SUMMIT THERAPEUTICS PLC
Agreement • December 6th, 2019 • Summit Therapeutics PLC • Pharmaceutical preparations • England and Wales
SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • June 3rd, 2024 • Summit Therapeutics Inc. • Pharmaceutical preparations • Delaware

This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of June 3, 2024, by and among Summit Therapeutics Inc., a Delaware corporation (the “Company”), and each of the entities listed on Exhibit A attached to this Agreement (each, an “Investor” and together, the “Investors”).

OPTION AGREEMENT
Option Agreement • January 30th, 2015 • Summit Corp PLC • Pharmaceutical preparations • England and Wales
Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions.
Summit Therapeutics PLC • April 13th, 2018 • Pharmaceutical preparations

AWARD/CONTRACT 1. THIS CONTRACT IS A RATED ORDER UNDER DPAS (15 CFR 700) Ø RATING PAGE OF PAGES 1 63 2. CONTRACT (Proc. Inst. Ident.) NO.HHSO100201700014C 3. EFFECTIVE DATESee Block 20C 4. REQUISITION/PURCHASE REQUEST/PROJECT NO.OS202400 6. ISSUED BY CODE ASPR-BARDA 6. ADMINISTERED BY (If other than Item 5) CODE ASPR-BARDA02 ASPR-BARDAO’NEILL HOUSE OFFICE BUILDINGWashington DC 20515 US DEPT OF HEALTH & HUMAN SERVICESASST SEC OF PREPAREDNESS & RESPONSEACQ MANAGEMENT, CONTRACTS, & GRANTSO’NEILL HOUSE OFFICE BUILDINGWashington DC 20515 7. NAME AND ADDRESS OF CONTRACTOR (No., Street, City, County, State and ZIP Code) SUMMIT (OXFORD) LIMITED 1510803[**]; 85B PARK DRIVE85B PARK DRIVEMILTON PARKABINGDON OXFORDSHIRE OX14 8. DELIVERY ¨ FOB ORIGIN x OTHER (See below) 9. DISCOUNT FOR PROMPT PAYMENT 10. SUBMIT NOTICES(4 copies unless otherwise specified)TO THE ADDRESS SHOWN IN Ø ITEM CODE 1510803 FACILITY CODE 11. SHIP TO/MAKE FOR CODE HHS/OS/ASPR 12. PAYMENT WILL MADE BY CODE DHHS/FMS

Contract
Summit Therapeutics Inc. • March 9th, 2023 • Pharmaceutical preparations
SUMMIT CORPORATION PLC EMI OPTION AGREEMENT «Forename» «Surname»
Emi Option Agreement • December 4th, 2014 • Summit Corp PLC • Pharmaceutical preparations

BY SUMMIT CORPORATION PLC (registered number 05197494 whose registered office is at 85b Park Drive, Milton Park, Abingdon, Oxfordshire, OX14 4RY (“the Company”).

May 28, 2021 Michael Donaldson Concord, MA 01742 Dear Michael:
Consulting Agreement • May 28th, 2021 • Summit Therapeutics Inc. • Pharmaceutical preparations • Massachusetts

This letter will confirm our discussion concerning the separation of your employment with Summit Therapeutics Inc. (the “Company”) effective on July 2, 2021 (the “Separation Date”).

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • January 10th, 2019 • Summit Therapeutics PLC • Pharmaceutical preparations • New York

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made and entered into as of January 9, 2019 by and among Summit Therapeutics plc, a public limited company incorporated in England and Wales with the Registrar of Companies of England and Wales (the “Company”), and the “Investor” named in that certain Securities Purchase Agreement by and among the Company and the Investor (the “Purchase Agreement”). Capitalized terms used herein have the respective meanings ascribed thereto in the Purchase Agreement unless otherwise defined herein.

LICENSE AND COLLABORATION AGREEMENT by and between SUMMIT (OXFORD) LTD and SAREPTA THERAPEUTICS, INC. Dated as of October 3, 2016
License and Collaboration Agreement • March 30th, 2017 • Summit Therapeutics PLC • Pharmaceutical preparations • New York
] American Depositary Shares Representing [ ] Ordinary Shares (Par Value £0.01 Per Share) SUMMIT THERAPEUTICS PLC UNDERWRITING AGREEMENT
Underwriting Agreement • February 20th, 2015 • Summit Therapeutics PLC • Pharmaceutical preparations • New York

The ADSs will be evidenced by American Depositary Receipts (“ADRs”) issued pursuant to that certain Deposit Agreement dated [ ], 2015 (the “Deposit Agreement”), by and among the Company, The Bank of New York Mellon, as depositary (the “Depositary”), and all holders and beneficial owners of ADSs issued thereunder. The Ordinary Shares to be issued in connection with, and represented by, the ADSs are hereinafter referred to as the “Underlying Securities.”

LEASE AGREEMENT by and between BRICKELL KEY CENTRE, LLC
Lease Agreement • May 1st, 2024 • Summit Therapeutics Inc. • Pharmaceutical preparations
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