Third Anniversary. Roche Bioscience may terminate the Research Collaboration effective as of the third anniversary of the Effective Date upon four months' advance written notice if the Research Management Committee decides that (a) the then current Research Plan does not provide opportunities for new Products (i.e. the Pathways have been fully exploited and no opportunities remain within the Field) or (b) Tularik has been unable to meet its obligations as defined in the Research Plan. [ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended.
Third Anniversary. On the Adjustment Date occurring on the third anniversary of the Commencement Date (the "Third Adjustment Date"), the Monthly Base Rent shall be determined by multiplying the Rentable Area by the sum of (A) $5.00, plus (B) the Year One Adjustment, plus (C) the Year Two Adjustment, plus (D) an amount determined by multiplying the CPI Increase for the Third Adjustment Date by the sum of (A), (B) and (C); provided , however, that in no event shall the Monthly Base Rent be adjusted on the Third Adjustment Date to an amount that is less than one hundred three and five/tenths percent (103.5%) of the amount obtained by multiplying the Rentable Area by the sum of $5.00 plus the Year One Adjustment plus the Year Two Adjustment, nor to an amount that is more than one hundred five and five/tenths percent (105.5%) of the amount obtained by multiplying the Rentable Area by the sum of $5.00 plus the Year One Adjustment plus the Year Two Adjustment.