Common use of Revised Costs Clause in Contracts

Revised Costs. Costs for this study are presented below in two categories, pass-through costs and professional fees. 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd. 07 November 2016 1.1.1 Pass-Through Costs Pass-through costs are in US dollars and include those expenses listed below. inVentiv Health Clinical will invoice Client for actual costs in these areas, it being understood that any pass-through costs in excess of the amounts set out below will require the Client’s prior written approval. inVentiv Health Clinical will use its best efforts to keep actual costs to reasonable levels through adherence to inVentiv Health Clinical’s travel policy and prudent negotiation with outside providers. Pass-through costs are presented in the table below: Site Visit Travel $[****] [****] $[****] [****] No change Investigators' Meeting Organization $[****] $[****] No change Kick-off Meeting Travel/Attendance $[****] $[****] No change Shipping/Photocopying $[****] $[****] No change Translation $[****] $[****] No change Regulatory Fees $[****] $[****] No change Ethics Committee Fees $[****] $[****] No change EDC Studies/3G Cards $[****] $[****] No change DSMB member fees $[****] $[****] Increased DSMB member hourly rate to $[****] from $[****] EDC Fees (Oracle) $[****] $[****] No change CRA Face to Face Meeting Travel expenses $[****] $[****] No change Pass Through Costs $[****] $[****] 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd. 07 November 2016 5 1.1.2 Investigator Grants Costs $[****] $[****] No Change Estimate only. Will be paid based on actual costs as approved by the Client. 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd.

Revised Costs. Costs for this study are presented below in two categories, pass-through costs and professional fees. 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd. 07 November 2016. 1.1.1 Pass-Through Costs Pass-through costs are in US dollars and include those expenses listed below. inVentiv Health Clinical will invoice Client for actual costs in these areas, it being understood that any pass-through costs in excess of the amounts set out below will require the Client’s prior written approval. inVentiv Health Clinical will use its best efforts to keep actual costs to reasonable levels through adherence to inVentiv Health Clinical’s travel policy and prudent negotiation with outside providers. Pass-through costs are presented in the table below: Site Visit Travel $[****] [****] $[****] [****] No change Investigators' Meeting Organization Organisation $[****] $[****] No change Kick-off Meeting Travel/Attendance $[****] $[****] No change change. Shipping/Photocopying $[****] $[****] No change Printing of Protocol v8, Investigator Brochure #10; Mini-protocols; Annotated Protocol v8 eCRF document; Pharmacy manuals; Quest lab chart tool; I/E laminated pocket cards; Protocol v8 IWRS Guidelines; [****] Guidelines DVD Translation $[****] $[****] No change Protocol v8 French and Spanish ICFs; French CSSi materials and I/E cards; Study Rationale Slides to French:; Dossier items translation to English Regulatory Fees $[****] $[****] No change Ethics Committee Fees $[****] $[****] No change Protocol v8 and [****] materials EDC Studies/3G Cards $[****] $[****] No change DSMB member fees $[****] $[****] Increased DSMB member hourly rate to $[****] from $[****] No change EDC Fees (Oracle) $[****] $[****] No change Change CRA Face to Face Meeting Travel expenses $[****] $[****] No change Pass Through Costs $[****] $[****] 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd. 07 November 2016 5change 1.1.2 Investigator Grants Costs $[****] $[****] No Change Estimate only. Will be paid based on actual costs as approved by the Client. 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd..

Revised Costs. Costs for this study are presented below in two categories, pass-through costs and professional fees. 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd. 07 November 2016. 1.1.1 Pass-Through Costs Pass-through costs are in US dollars and include those expenses listed below. inVentiv Health Clinical will invoice Client for actual costs in these areas, it being understood that any pass-through costs in excess of the amounts set out below will require the Client’s prior written approval. inVentiv Health Clinical will use its best efforts to keep actual costs to reasonable levels through adherence to inVentiv Health Clinical’s travel policy and prudent negotiation with outside providers. Pass-through costs are presented in the table below: Site Visit Travel $[****] [****] $[****] [****] No change Investigators' Meeting Organization $[****] $[****] No change Kick-off Meeting Travel/Attendance $[****] $[****] No change Shipping/Photocopying $[****] $[****] No change Translation $[****] $[****] No change Regulatory Fees $[****] $[****] No change Ethics Committee Fees $[****] $[****] No change EDC Studies/3G Cards $[****] $[****] No change DSMB member fees $[****] $[****] Increased DSMB member hourly rate to $[****] from $[****] No change EDC Fees (Oracle) $[****] $[****] No change CRA Face to Face Meeting Travel expenses $[****] $[****] No change Pass Through Costs $[****] $[****] 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd. 07 November 2016 5] 1.1.2 Investigator Grants Costs $[****] $[****] No Change Estimate only. Will be paid based on actual costs as approved by the Client. 11ISB001 7810962 Canada Inc., /RedHill Biopharma Ltd..