Common use of Palladium Clause in Contracts

Palladium. charcoal (5%) until the reaction was complete. The catalyst and solvent were removed to give 5 g. N,N-diethyl-N'-(4-aminobenzoyl)-ethylenediamine in the form of an oil. c) A solution of 2.35 g. N,N-diethyl-N'-(4-aminobenzoyl)-ethylenediamine in 20 ml. 2N hydrochloric acid was cooled to -5 degrees C. and treated with 8 ml. of a 10% aqueous solution of sodium nitrite. The reaction mixture was stirred for 30 minutes and added to 1.4 g. salicylic acid in a solution of 1.6 g. sodium hydroxide and 2 g. sodium carbonate in 20 ml. water. After 3 hours at 0 to 20 degrees C., sodium chloride was added to the reaction mixture to salt out the desired diazo compound. This was filtered off, washed with water and hot methanol and dried to give 2.3 g. 5-(4-diethyl-aminoethylcarbamoylphenylazo)- salicylic acid; m.p. 252 - 254 degrees C. (decomp.). The pharmaceutical compositions according to the present invention contain at least one of the compounds (R&D Schedule 1 cont...) -20-