Metabotropic Glutamate Receptors Classification Sample Clauses

Metabotropic Glutamate Receptors Classification. To date, eight members of the G-protein-coupled metabotropic glutamate receptor family have been identified (mGluR1–8) which have been divided on the basis of sequence homology, second messenger coupling and pharmacology into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7, 8). Compared to the effect of ionotropic receptors, the activation of mGluRs leads to a slower and longer lasting effect on cellular excitability. Thus, mGluRs have the capacity to provide a mechanism by which glutamate can modulate or fine-tune activity at the same synapses at which it elicits fast synaptic responses through ionotropic receptors. The mGluRs have seven trans-membrane domains with an extracellular N-terminal and intracellular COOH terminal. They display little sequence homology with other metabotropic receptors, except for a modest resemblance to GABAB receptors. However, mGluRs of the same group show about 70% sequence identity, whereas between groups this percentage decreases to about 45% (Conn and Pin, 1997). This classification is also supported by the respective transduction mechanisms of the different mGluR subtypes. The group I mGluRs predominantly couple via Gq/G11 to phospholipase C, whereas the group II and group III receptors couple with Gi/Go to inhibit adenylyl cyclase activity. Although mGluR family members can mediate synaptic transmission via activation of slow excitatory postsynaptic potentials, they generally exert a more modulatory role, regulating neuronal excitability, synaptic transmission and plasticity. mGluR-mediated signalling is achieved both via the activation of intracellular second messenger pathways and subsequent regulation of downstream effectors, and through the direct action of the βγ subunits of the heterotrimeric G protein (Anwyl, 1999). Distribution studies have shown mGluR mRNA and protein expression in many cortical and subcortical regions of the CNS. The striatum is enriched in all mGluR subtypes, except for mGluR6 which is solely expressed in the retina (Duvoisin et al., 2005).
Sample 1
AutoNDA by SimpleDocs

Related to Metabotropic Glutamate Receptors Classification

  • Hepatitis B Vaccine Where the Hospital identifies high risk areas where employees are exposed to Hepatitis B, the Hospital will provide, at no cost to the employees, a Hepatitis B vaccine.

  • Preceptor Pay Any nurse assigned as a preceptor shall receive a premium of one dollar fifty cents ($1.50) per hour.

  • Volunteer Firefighting Leave Leave without pay will be granted when an employee who is a volunteer firefighter is called to duty to respond to a fire, natural disaster or medical emergency.

  • Human Leukocyte Antigen Testing This plan covers human leukocyte antigen testing for A, B, and DR antigens once per member per lifetime to establish a member’s bone marrow transplantation donor suitability in accordance with R.I. General Law §27-20-36. The testing must be performed in a facility that is: • accredited by the American Association of Blood Banks or its successors; and • licensed under the Clinical Laboratory Improvement Act as it may be amended from time to time. At the time of testing, the person being tested must complete and sign an informed consent form that also authorizes the results of the test to be used for participation in the National Marrow Donor program.

  • Loop Provisioning Involving Integrated Digital Loop Carriers 2.6.1 Where EveryCall has requested an Unbundled Loop and BellSouth uses Integrated Digital Loop Carrier (IDLC) systems to provide the local service to the end user and BellSouth has a suitable alternate facility available, BellSouth will make such alternative facilities available to EveryCall. If a suitable alternative facility is not available, then to the extent it is technically feasible, BellSouth will implement one of the following alternative arrangements for EveryCall (e.g. hairpinning):

  • Vaccination and Inoculation (a) The Employer agrees to take all reasonable precautions, including in-service seminars, to limit the spread of infectious diseases among employees.

  • SPECIALIZED JOB CLASSES Where there is a particular specialized job class in which the pay rate is below the local market value assessment of that job class, the parties may use existing means under the collective agreement to adjust compensation for that job class.

  • Influenza Vaccine Upon recommendation of the Medical Officer of Health, all employees shall be required, on an annual basis to be vaccinated and or to take antiviral medication for influenza. If the costs of such medication are not covered by some other sources, the Employer will pay the cost for such medication. If the employee fails to take the required medication, she may be placed on an unpaid leave of absence during any influenza outbreak in the home until such time as the employee has been cleared by the public health or the Employer to return to the work environment. The only exception to this would be employees for whom taking the medication will result in the employee being physically ill to the extent that she cannot attend work. Upon written direction from the employee’s physician of such medical condition in consultation with the Employer’s physician, (if requested), the employee will be permitted to access their sick bank, if any, during any outbreak period. If there is a dispute between the physicians, the employee will be placed on unpaid leave. If the employee gets sick as a reaction to the drug and applies for WSIB the Employer will not oppose the application. If an employee is pregnant and her physician believes the pregnancy could be in jeopardy as a result of the influenza inoculation and/or the antiviral medication she shall be eligible for sick leave in circumstances where she is not allowed to attend at work as a result of an outbreak. This clause shall be interpreted in a manner consistent with the Ontario Human Rights Code.

  • Selection of Subcontractors, Procurement of Materials and Leasing of Equipment The contractor shall not discriminate on the grounds of race, color, religion, sex, national origin, age or disability in the selection and retention of subcontractors, including procurement of materials and leases of equipment. The contractor shall take all necessary and reasonable steps to ensure nondiscrimination in the administration of this contract.

  • Client Classification 7.1. We shall not have an obligation to treat our clients in different classes depending on their knowledge and expertise.

Time is Money Join Law Insider Premium to draft better contracts faster.