Hypotheses & Aims Sample Clauses

Hypotheses & Aims. 1.1 The nitric oxide signalling cascade and the cardiovascular system‌ Since the discovery that the Endothelium-Derived Relaxing Factor (EDRF) was nitric oxide (NO)[1, 2], over the last four decades NO has been identified as a key signalling molecule in the cardiovascular system and multiple other organ systems. The importance of the discovery and identification of NO as EDRF is reflected by the award of the 1998 Nobel Prize in Medicine to Furchgott, Xxxxx, and Xxxxxxx[3]. NO is a free radical gas, with a half-life in the circulation of ~20ms[4]. In humans, it is produced via two key mechanisms: the “L-arginine-nitric oxide pathway” as originally described by Xxxxxxx[5] and the more recently discovered nitrate-nitrite- NO pathway[6]. The L-arginine-nitric oxide pathway involves the generation of NO via the conversion of L-arginine to L-citrulline by haem- and xxxxxx-containing nitric oxide synthase (NOS) enzymes[7] in a process that requires dimerism of the NOS enzyme and the presence of the co-factors tetrahydrobiopterin (BH4), nicotinamide adenine dinucleotide phosphate (NADPH) and O2[8]. Three NOS isoenzymes have been identified in humans; endothelial (xXXX), neuronal (nNOS) and inducible (iNOS). As will be discussed in detail below, xXXX and nNOS are constitutively expressed and have distinct roles in the regulation of cardiovascular function. By contrast, the role of iNOS is in relation to host response to infection and inflammation. While the production of NO by xXXX and nNOS is Ca2+/calmodulin-dependent, production of NO by iNOS will continue until the enzyme is degraded, resulting in higher local concentrations of NO[9]. The nitrate-nitrite-NO pathway (also known as the enterosalivary pathway) describes the two-step process by which orally ingested inorganic nitrate (NO -) is reduced to NO via inorganic nitrite (NO -). The discovery of the nitrate-nitrite-NO pathway significantly altered the understanding of the role of inorganic nitrate and nitrite in relation to the cardiovascular system. Previously, they were considered to be inert by-products of NO oxidation. However, it is now recognised that dietary nitrate is converted, via nitrite, to NO[10, 11]. Due to the half-life of nitrite being significantly longer than NO in the blood, nitrite therefore represents a circulating pool of potentially bioavailable NO. NO signalling in the vasculature‌ NO’s role as a signalling molecule in the vasculature occurs primarily in a paracrine fashion i.e. NO pr...
AutoNDA by SimpleDocs
Hypotheses & Aims. ‌ Hypothesis relating to inorganic nitrite‌ The hypothesis underpinning the inorganic nitrite studies in this thesis is that, in addition to its actions on conduit arteries (which are cGMP-independent), nitrite exerts a direct myocardial effect. Hypothesis relating to dietary nitrate and the nitrate-nitrite-NO pathway‌ The hypothesis underpinning the dietary nitrate studies is that the conversion of inorganic nitrate to nitrite can be manipulated through intervening on physiological redox mechanisms. Aims:‌

Related to Hypotheses & Aims

  • Adjustment of Grievance The School District and the teacher shall attempt to adjust all grievances which may arise during the course of employment of any teacher within the School District in the following manner:

  • Account Verification Whether or not a Default or Event of Default exists, Agent shall have the right at any time, in the name of Agent, any designee of Agent or any Borrower, to verify the validity, amount or any other matter relating to any Accounts of Borrowers by mail, telephone or otherwise. Borrowers shall cooperate fully with Agent in an effort to facilitate and promptly conclude any such verification process.

  • Instructional Framework The District and the Association have agreed to the adopted research-based instructional framework developed by Xxxxxxxxx Xxxxxxxxx and approved by OSPI. The Association and District have also agreed to Xxxxxxxxx Xxxxxxxxx’x frameworks for specialists for use with other certificated educators.

  • cont'd The volume and proportion of Credits relating to learners from different protected characteristic groups and Care Experienced Disability - Volume of Credits delivered to students with a known disability 31,014 31,875 32,355 32,355 Proportion 16.7% 17.1% 17.3% 17.3% Care Experience - Volume of Credits delivered to students with Care Experience 1,617 2,066 2,231 2,439 Proportion 0.9% 1.1% 1.2% 1.3%

  • Grievance and Appeals Unit See Section 9 for contact information. You may also contact the Office of the Health Insurance Commissioner’s Consumer Resource Program, RIREACH at 1-855-747-3224 about questions or concerns you may have. Complaints A complaint is an expression of dissatisfaction with any aspect of our operation or the quality of care you received from a healthcare provider. A complaint is not an appeal. For information about submitting an appeal, please see the Reconsiderations and Appeals section below. We encourage you to discuss any concerns or issues you may have about any aspect of your medical treatment with the healthcare provider that furnished the care. In most cases, issues can be more easily resolved if they are raised when they occur. However, if you remain dissatisfied or prefer not to take up the issue with your provider, you can call our Customer Service Department for further assistance. You may also call our Customer Service Department if you are dissatisfied with any aspect of our operation. If the concern or issue is not resolved to your satisfaction, you may file a verbal or written complaint with our Grievance and Appeals Unit. We will acknowledge receipt of your complaint or administrative appeal within ten (10) business days. The Grievance and Appeals Unit will conduct a thorough review of your complaint and respond within thirty (30) calendar days of the date it was received. The determination letter will provide you with the rationale for our response as well as information on any possible next steps available to you. When filing a complaint, please provide the following information: • your name, address, member ID number; • the date of the incident or service; • summary of the issue; • any previous contact with BCBSRI concerning the issue; • a brief description of the relief or solution you are seeking; and • additional information such as referral forms, claims, or any other documentation that you would like us to review. Please send all information to the address listed on the Contact Information section.

  • Description of Covered Items Mechanical parts and components of basic single water softener unit, including central head assembly; multi-level/twin softeners; piping to and from unit(s) and system tanks. Examples of Items/Conditions Not Covered: Any and all treatment, purification, odor control, iron filtration components and systems; discharge drywells; failure due to excessive water pressure or freeze damage; failures due to mineral and/or sediment; resin bed replacement and salt.

  • Contract Number All purchase orders issued by purchasing entities within the jurisdiction of this Addendum shall include the Participating State Addendum Number: 46151504-NASPO-17-ACS. This Addendum and Master Agreement number RFP-NK-15-001 (administered by the State of Colorado) together with its exhibits, set forth the entire agreement between the Parties with respect to the subject matter of all previous communications, representations or agreements, whether oral or written, with respect to the subject matter hereof. Terms and conditions inconsistent with, contrary or in addition to the terms and conditions of this Addendum and the Contract, together with its exhibits, shall not be added to or incorporated into this Addendum or the Contract and its exhibits, by any subsequent purchase order or otherwise, and any such attempts to add or incorporate such terms and conditions are hereby rejected. The terms and conditions of this Addendum and the Contract and its exhibits shall prevail and govern in the case of any such inconsistent or additional terms within the Participating State.

  • Completion of Evaluation Cycle 1. The summative evaluation rating shall be based upon a preponderance of the evidence, assessed in a holistic manner, that is aligned to the Ohio Educator Standards. Only evidence gathered during the walkthroughs and formal observations that are conducted for the current school year may be used.

  • Statement of Grievance The grievance shall contain a statement of:

  • Long Term Cost Evaluation Criterion # 4 READ CAREFULLY and see in the RFP document under "Proposal Scoring and Evaluation". Points will be assigned to this criterion based on your answer to this Attribute. Points are awarded if you agree not i ncrease your catalog prices (as defined herein) more than X% annually over the previous year for years two and thr ee and potentially year four, unless an exigent circumstance exists in the marketplace and the excess price increase which exceeds X% annually is supported by documentation provided by you and your suppliers and shared with TIP S, if requested. If you agree NOT to increase prices more than 5%, except when justified by supporting documentati on, you are awarded 10 points; if 6% to 14%, except when justified by supporting documentation, you receive 1 to 9 points incrementally. Price increases 14% or greater, except when justified by supporting documentation, receive 0 points. increases will be 5% or less annually per question Required Confidentiality Claim Form Required Confidentiality Claim Form This completed form is required by TIPS. By submitting a response to this solicitation you agree to download from th e “Attachments” section, complete according to the instructions on the form, then uploading the completed form, wit h any confidential attachments, if applicable, to the “Response Attachments” section titled “Confidentiality Form” in order to provide to TIPS the completed form titled, “CONFIDENTIALITY CLAIM FORM”. By completing this process, you provide us with the information we require to comply with the open record laws of the State of Texas as they ma y apply to your proposal submission. If you do not provide the form with your proposal, an award will not be made if your proposal is qualified for an award, until TIPS has an accurate, completed form from you. Read the form carefully before completing and if you have any questions, email Xxxx Xxxxxx at TIPS at xxxx.xxxxxx@t xxx-xxx.xxx

Time is Money Join Law Insider Premium to draft better contracts faster.