Inorganic nitrite Clause Samples

Inorganic nitrite. ‌ As discussed above, in addition to being formed from the reduction of dietary nitrate in the oral cavity, nitrite is also a by-product of NO metabolism: NO is oxidised in cells by cytochrome C oxidase and in blood by caeruloplasmin[69, 70]. Although the physiological effects of nitrite have only been described and recognised relatively recently (see below), the therapeutic potential of nitrite was first recognised in the 9th century AD, with Chinese documents remarking on its ability to relieve “acute heart pains, and cold in the hands and feet.”[71]. Approximately 70% of circulating nitrite is derived from the L-arginine NO synthase pathway[72] (with the remaining 30% ingested as dietary nitrate and converted to inorganic nitrite via the nitrate-nitrite-NO pathway[73]). Production of NO from nitrite by acidic disproportionation‌ In the acidic conditions of the human stomach nitrite is converted to NO via nitrous acid and nitrogen oxides (see equations 2-4 below): Equation 2 𝑁𝑂− + 𝐻+ ⇌ 𝐻𝑁𝑂