Hypotheses & Aims. Hypothesis relating to inorganic nitrite The hypothesis underpinning the inorganic nitrite studies in this thesis is that, in addition to its actions on conduit arteries (which are cGMP-independent), nitrite exerts a direct myocardial effect. Hypothesis relating to dietary nitrate and the nitrate-nitrite-NO pathway The hypothesis underpinning the dietary nitrate studies is that the conversion of inorganic nitrate to nitrite can be manipulated through intervening on physiological redox mechanisms. Aims: 1. To investigate the mechanism of action of inorganic nitrite conduit artery dilatation. 2. To investigate the physiological effects of inorganic nitrite on coronary arteries and on left ventricular function. 3. To investigate the mechanisms that surround the conversion of salivary nitrate to nitrite in the human oral cavity.
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